ID   PCPR_SPHCR              Reviewed;         307 AA.
AC   P52679;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   21-JUN-2005, sequence version 2.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=PCP degradation transcriptional activation protein;
GN   Name=pcpR;
OS   Sphingobium chlorophenolicum.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Sphingomonadales;
OC   Sphingomonadaceae; Sphingobium.
OX   NCBI_TaxID=46429;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 39723 / DSM 6824 / L-1;
RA   Lange C.C.;
RT   "Molecular analysis of pentachlorophenol degradation by Flavobacterium sp.
RT   strain ATCC 39723.";
RL   Thesis (1994), University of Idaho, United States.
RN   [2]
RP   SEQUENCE REVISION, AND FUNCTION.
RC   STRAIN=ATCC 39723 / DSM 6824 / L-1;
RX   PubMed=12169590; DOI=10.1128/jb.184.17.4672-4680.2002;
RA   Cai M., Xun L.;
RT   "Organization and regulation of pentachlorophenol-degrading genes in
RT   Sphingobium chlorophenolicum ATCC 39723.";
RL   J. Bacteriol. 184:4672-4680(2002).
CC   -!- FUNCTION: Transcriptional activator for the pcpA, pcpB and pcpE genes
CC       for pentachlorophenol (PCP) degradation. Essential for PCP degradation.
CC       {ECO:0000269|PubMed:12169590}.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; U12290; AAA68939.2; -; Genomic_DNA.
DR   PDB; 4RNS; X-ray; 2.70 A; A/B/C/D=85-307.
DR   PDB; 4RPN; X-ray; 2.27 A; A/B/C/D=85-307.
DR   PDB; 4RPO; X-ray; 1.95 A; A/B/C/D=85-307.
DR   PDBsum; 4RNS; -.
DR   PDBsum; 4RPN; -.
DR   PDBsum; 4RPO; -.
DR   AlphaFoldDB; P52679; -.
DR   SMR; P52679; -.
DR   PRIDE; P52679; -.
DR   eggNOG; COG0583; Bacteria.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0019439; P:aromatic compound catabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Activator; Aromatic hydrocarbons catabolism; DNA-binding;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..307
FT                   /note="PCP degradation transcriptional activation protein"
FT                   /id="PRO_0000105741"
FT   DOMAIN          6..63
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        23..42
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   TURN            92..94
FT                   /evidence="ECO:0007829|PDB:4RPO"
FT   STRAND          98..102
FT                   /evidence="ECO:0007829|PDB:4RPO"
FT   HELIX           105..111
FT                   /evidence="ECO:0007829|PDB:4RPO"
FT   HELIX           112..114
FT                   /evidence="ECO:0007829|PDB:4RPO"
FT   HELIX           116..122
FT                   /evidence="ECO:0007829|PDB:4RPO"
FT   STRAND          127..131
FT                   /evidence="ECO:0007829|PDB:4RPO"
FT   HELIX           138..143
FT                   /evidence="ECO:0007829|PDB:4RPO"
FT   STRAND          148..152
FT                   /evidence="ECO:0007829|PDB:4RPO"
FT   STRAND          161..169
FT                   /evidence="ECO:0007829|PDB:4RPO"
FT   STRAND          171..176
FT                   /evidence="ECO:0007829|PDB:4RPO"
FT   HELIX           181..184
FT                   /evidence="ECO:0007829|PDB:4RPO"
FT   HELIX           188..193
FT                   /evidence="ECO:0007829|PDB:4RPO"
FT   STRAND          194..199
FT                   /evidence="ECO:0007829|PDB:4RPO"
FT   HELIX           202..204
FT                   /evidence="ECO:0007829|PDB:4RPO"
FT   HELIX           208..218
FT                   /evidence="ECO:0007829|PDB:4RPO"
FT   HELIX           221..223
FT                   /evidence="ECO:0007829|PDB:4RPO"
FT   STRAND          224..229
FT                   /evidence="ECO:0007829|PDB:4RPO"
FT   HELIX           231..240
FT                   /evidence="ECO:0007829|PDB:4RPO"
FT   STRAND          241..248
FT                   /evidence="ECO:0007829|PDB:4RPO"
FT   HELIX           249..256
FT                   /evidence="ECO:0007829|PDB:4RPO"
FT   STRAND          257..259
FT                   /evidence="ECO:0007829|PDB:4RPO"
FT   STRAND          261..264
FT                   /evidence="ECO:0007829|PDB:4RPO"
FT   STRAND          273..280
FT                   /evidence="ECO:0007829|PDB:4RPO"
FT   HELIX           281..283
FT                   /evidence="ECO:0007829|PDB:4RPO"
FT   HELIX           287..297
FT                   /evidence="ECO:0007829|PDB:4RPO"
SQ   SEQUENCE   307 AA;  34664 MW;  D151ECB293684BE9 CRC64;
     MNDSVLPLGH LMVFDALYRH GSAGKAAHAL SMPQPTLSRW LAQLRTHFDD PLFVRTRSGM
     EPTPLAARAA PHIAEMIAIY RQHVRSELRF DPGTSNRNFR IAASDFGQAL MLPRLYATLE
     ETAPQVRVTG VNLRHGPLVE ELESGSIDIA FGGFPTLSAG IKTQTLFREE YVCVMRQSHP
     ALTHGLDLEA FRQCRHIIVT AHEFNHVHEQ VEARLLELLP PESIRFTTEN FLVSAVIAEE
     TDVILTIPSR LARWFANRGG LTIFPVPIEL PSIEVKQYWH ERYDKDPGNI WLRRVIAKIG
     FQNPPAE