ID   PCP_PYRAB               Reviewed;         200 AA.
AC   Q9UYQ9; G8ZIL1;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Pyrrolidone-carboxylate peptidase;
DE            EC=3.4.19.3;
DE   AltName: Full=5-oxoprolyl-peptidase;
DE   AltName: Full=Pyroglutamyl-peptidase I;
DE            Short=PGP-I;
DE            Short=Pyrase;
GN   Name=pcp; OrderedLocusNames=PYRAB14480; ORFNames=PAB1419;
OS   Pyrococcus abyssi (strain GE5 / Orsay).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=272844;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GE5 / Orsay;
RX   PubMed=12622808; DOI=10.1046/j.1365-2958.2003.03381.x;
RA   Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O.,
RA   Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J.,
RA   Weissenbach J., Zivanovic Y., Forterre P.;
RT   "An integrated analysis of the genome of the hyperthermophilic archaeon
RT   Pyrococcus abyssi.";
RL   Mol. Microbiol. 47:1495-1512(2003).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=GE5 / Orsay;
RX   PubMed=22057919; DOI=10.1007/s00284-011-0035-x;
RA   Gao J., Wang J.;
RT   "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and
RT   Pyrococcus furiosus DSM 3638.";
RL   Curr. Microbiol. 64:118-129(2012).
CC   -!- FUNCTION: Removes 5-oxoproline from various penultimate amino acid
CC       residues except L-proline.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Release of an N-terminal pyroglutamyl group from a
CC         polypeptide, the second amino acid generally not being Pro.;
CC         EC=3.4.19.3;
CC   -!- SUBUNIT: Homotetramer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the peptidase C15 family. {ECO:0000305}.
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DR   EMBL; AJ248287; CAB50353.1; -; Genomic_DNA.
DR   EMBL; HE613800; CCE70894.1; -; Genomic_DNA.
DR   PIR; D75057; D75057.
DR   RefSeq; WP_010868563.1; NC_000868.1.
DR   AlphaFoldDB; Q9UYQ9; -.
DR   SMR; Q9UYQ9; -.
DR   STRING; 272844.PAB1419; -.
DR   MEROPS; C15.001; -.
DR   EnsemblBacteria; CAB50353; CAB50353; PAB1419.
DR   GeneID; 1495723; -.
DR   KEGG; pab:PAB1419; -.
DR   PATRIC; fig|272844.11.peg.1539; -.
DR   eggNOG; arCOG05850; Archaea.
DR   HOGENOM; CLU_043960_4_0_2; -.
DR   OMA; HHIATRA; -.
DR   OrthoDB; 97570at2157; -.
DR   PhylomeDB; Q9UYQ9; -.
DR   Proteomes; UP000000810; Chromosome.
DR   Proteomes; UP000009139; Chromosome.
DR   GO; GO:0005829; C:cytosol; IEA:InterPro.
DR   GO; GO:0016920; F:pyroglutamyl-peptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd00501; Peptidase_C15; 1.
DR   Gene3D; 3.40.630.20; -; 1.
DR   HAMAP; MF_00417; Pyrrolid_peptidase; 1.
DR   InterPro; IPR000816; Peptidase_C15.
DR   InterPro; IPR016125; Peptidase_C15-like.
DR   InterPro; IPR036440; Peptidase_C15-like_sf.
DR   InterPro; IPR029762; PGP-I_bact-type.
DR   InterPro; IPR033694; PGPEP1_Cys_AS.
DR   InterPro; IPR033693; PGPEP1_Glu_AS.
DR   PANTHER; PTHR23402; PTHR23402; 1.
DR   Pfam; PF01470; Peptidase_C15; 1.
DR   PIRSF; PIRSF015592; Prld-crbxl_pptds; 1.
DR   PRINTS; PR00706; PYROGLUPTASE.
DR   SUPFAM; SSF53182; SSF53182; 1.
DR   TIGRFAMs; TIGR00504; pyro_pdase; 1.
DR   PROSITE; PS01334; PYRASE_CYS; 1.
DR   PROSITE; PS01333; PYRASE_GLU; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Hydrolase; Protease; Thiol protease.
FT   CHAIN           1..200
FT                   /note="Pyrrolidone-carboxylate peptidase"
FT                   /id="PRO_0000184754"
FT   ACT_SITE        79
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        142
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        166
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   200 AA;  22082 MW;  6F97DB87529D222A CRC64;
     MKVLVTGFEP FGGDDKNPTM EIVKFLDGKE IGGAKVIGRV LPVSFKRARK ELVAILDEIK
     PDVTINLGLA PGRTHISVER VAVNIIDARI PDNDGEKPID EPIVENGPAA YFATIPTREI
     VEEMKRNNIP AVLSYTAGTY LCNFVMYLTL HHSATKGYPR KAGFIHVPYT PDQVIEKKNT
     PSMSLELEIK GVEIAIRKSL