PCR10_ARATH
ID PCR10_ARATH Reviewed; 190 AA.
AC Q8S8T8; B3H5K6; Q0WRW9; Q3EBI6;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Protein PLANT CADMIUM RESISTANCE 10;
DE Short=AtPCR10;
GN Name=PCR10; OrderedLocusNames=At2g40935; ORFNames=T20B5;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RA Bautista V.R., Kim C.J., Chen H., Quinitio C., Ecker J.R.;
RT "Arabidopsis ORF Clones.";
RL Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP FUNCTION, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=15181212; DOI=10.1104/pp.103.037739;
RA Song W.Y., Martinoia E., Lee J., Kim D., Kim D.Y., Vogt E., Shim D.,
RA Choi K.S., Hwang I., Lee Y.;
RT "A novel family of cys-rich membrane proteins mediates cadmium resistance
RT in Arabidopsis.";
RL Plant Physiol. 135:1027-1039(2004).
CC -!- FUNCTION: May be involved in cadmium resistance.
CC {ECO:0000269|PubMed:15181212}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8S8T8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8S8T8-2; Sequence=VSP_040962;
CC Name=3;
CC IsoId=Q8S8T8-3; Sequence=VSP_040960, VSP_040961;
CC -!- SIMILARITY: Belongs to the cornifelin family. {ECO:0000305}.
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DR EMBL; AC002409; AAM14839.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC09901.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC09902.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC09903.1; -; Genomic_DNA.
DR EMBL; CP002685; ANM62344.1; -; Genomic_DNA.
DR EMBL; CP002685; ANM62345.1; -; Genomic_DNA.
DR EMBL; CP002685; ANM62346.1; -; Genomic_DNA.
DR EMBL; CP002685; ANM62347.1; -; Genomic_DNA.
DR EMBL; CP002685; ANM62348.1; -; Genomic_DNA.
DR EMBL; CP002685; ANM62349.1; -; Genomic_DNA.
DR EMBL; AY085101; AAM61655.1; -; mRNA.
DR EMBL; AK228174; BAF00130.1; -; mRNA.
DR EMBL; BT029441; ABK59670.1; -; mRNA.
DR RefSeq; NP_001118490.1; NM_001125018.1. [Q8S8T8-2]
DR RefSeq; NP_001318397.1; NM_001336877.1. [Q8S8T8-1]
DR RefSeq; NP_001324506.1; NM_001336881.1. [Q8S8T8-3]
DR RefSeq; NP_001324507.1; NM_001336882.1. [Q8S8T8-1]
DR RefSeq; NP_001324508.1; NM_001336880.1. [Q8S8T8-1]
DR RefSeq; NP_001324509.1; NM_001336878.1. [Q8S8T8-3]
DR RefSeq; NP_001324510.1; NM_001336879.1. [Q8S8T8-1]
DR RefSeq; NP_565945.1; NM_129657.3. [Q8S8T8-1]
DR RefSeq; NP_850339.1; NM_180008.2. [Q8S8T8-3]
DR AlphaFoldDB; Q8S8T8; -.
DR STRING; 3702.AT2G40935.1; -.
DR PaxDb; Q8S8T8; -.
DR PRIDE; Q8S8T8; -.
DR ProteomicsDB; 236287; -. [Q8S8T8-1]
DR EnsemblPlants; AT2G40935.1; AT2G40935.1; AT2G40935. [Q8S8T8-1]
DR EnsemblPlants; AT2G40935.2; AT2G40935.2; AT2G40935. [Q8S8T8-3]
DR EnsemblPlants; AT2G40935.3; AT2G40935.3; AT2G40935. [Q8S8T8-2]
DR EnsemblPlants; AT2G40935.4; AT2G40935.4; AT2G40935. [Q8S8T8-3]
DR EnsemblPlants; AT2G40935.5; AT2G40935.5; AT2G40935. [Q8S8T8-1]
DR EnsemblPlants; AT2G40935.6; AT2G40935.6; AT2G40935. [Q8S8T8-1]
DR EnsemblPlants; AT2G40935.7; AT2G40935.7; AT2G40935. [Q8S8T8-3]
DR EnsemblPlants; AT2G40935.8; AT2G40935.8; AT2G40935. [Q8S8T8-1]
DR EnsemblPlants; AT2G40935.9; AT2G40935.9; AT2G40935. [Q8S8T8-1]
DR GeneID; 818692; -.
DR Gramene; AT2G40935.1; AT2G40935.1; AT2G40935. [Q8S8T8-1]
DR Gramene; AT2G40935.2; AT2G40935.2; AT2G40935. [Q8S8T8-3]
DR Gramene; AT2G40935.3; AT2G40935.3; AT2G40935. [Q8S8T8-2]
DR Gramene; AT2G40935.4; AT2G40935.4; AT2G40935. [Q8S8T8-3]
DR Gramene; AT2G40935.5; AT2G40935.5; AT2G40935. [Q8S8T8-1]
DR Gramene; AT2G40935.6; AT2G40935.6; AT2G40935. [Q8S8T8-1]
DR Gramene; AT2G40935.7; AT2G40935.7; AT2G40935. [Q8S8T8-3]
DR Gramene; AT2G40935.8; AT2G40935.8; AT2G40935. [Q8S8T8-1]
DR Gramene; AT2G40935.9; AT2G40935.9; AT2G40935. [Q8S8T8-1]
DR KEGG; ath:AT2G40935; -.
DR Araport; AT2G40935; -.
DR TAIR; locus:505006313; AT2G40935.
DR eggNOG; ENOG502RV9Z; Eukaryota.
DR HOGENOM; CLU_083147_0_0_1; -.
DR OMA; QEYREIC; -.
DR PhylomeDB; Q8S8T8; -.
DR PRO; PR:Q8S8T8; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q8S8T8; baseline and differential.
DR Genevisible; Q8S8T8; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR006461; PLAC_motif_containing.
DR PANTHER; PTHR15907; PTHR15907; 1.
DR Pfam; PF04749; PLAC8; 1.
DR TIGRFAMs; TIGR01571; A_thal_Cys_rich; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..190
FT /note="Protein PLANT CADMIUM RESISTANCE 10"
FT /id="PRO_0000407726"
FT TRANSMEM 78..98
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 108..125
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..24
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|Ref.4"
FT /id="VSP_040960"
FT VAR_SEQ 25..61
FT /note="VETTTPNLEIAVSESTKDDPRQWSSGICACFDDMQSC -> MVIWYMRLLRR
FT YAELYATTLCHPNLLHFTTRIKFVKG (in isoform 3)"
FT /evidence="ECO:0000303|Ref.4"
FT /id="VSP_040961"
FT VAR_SEQ 51..61
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_040962"
SQ SEQUENCE 190 AA; 20799 MW; 4592C9E78538E360 CRC64;
MKEKKGHYVP PSYIPLTQSD ADTEVETTTP NLEIAVSEST KDDPRQWSSG ICACFDDMQS
CCVGLFCPCY IFGKNAELLG SGTFAGPCLT HCISWALVNT ICCFATNGAL LGLPGCFVSC
YACGYRKSLR AKYNLQEAPC GDFVTHFFCH LCAICQEYRE IREQSSGSYP LDMKMAITNA
PLAQTMESAN
