ID   PCR4_ARATH              Reviewed;         184 AA.
AC   Q9LS44;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Protein PLANT CADMIUM RESISTANCE 4;
DE            Short=AtPCR4;
GN   Name=PCR4; OrderedLocusNames=At3g18460; ORFNames=MYF24.18;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA   Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT   features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT   clones.";
RL   DNA Res. 7:131-135(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=15181212; DOI=10.1104/pp.103.037739;
RA   Song W.Y., Martinoia E., Lee J., Kim D., Kim D.Y., Vogt E., Shim D.,
RA   Choi K.S., Hwang I., Lee Y.;
RT   "A novel family of cys-rich membrane proteins mediates cadmium resistance
RT   in Arabidopsis.";
RL   Plant Physiol. 135:1027-1039(2004).
CC   -!- FUNCTION: May be involved in heavy metals transport. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the cornifelin family. {ECO:0000305}.
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DR   EMBL; AB026658; BAB01112.1; -; Genomic_DNA.
DR   EMBL; CP002686; AEE76100.1; -; Genomic_DNA.
DR   RefSeq; NP_188475.1; NM_112731.1.
DR   AlphaFoldDB; Q9LS44; -.
DR   PaxDb; Q9LS44; -.
DR   PRIDE; Q9LS44; -.
DR   EnsemblPlants; AT3G18460.1; AT3G18460.1; AT3G18460.
DR   GeneID; 821375; -.
DR   Gramene; AT3G18460.1; AT3G18460.1; AT3G18460.
DR   KEGG; ath:AT3G18460; -.
DR   Araport; AT3G18460; -.
DR   TAIR; locus:2095092; AT3G18460.
DR   eggNOG; ENOG502RXFT; Eukaryota.
DR   HOGENOM; CLU_083147_1_1_1; -.
DR   InParanoid; Q9LS44; -.
DR   OMA; ITCLAPC; -.
DR   OrthoDB; 1354725at2759; -.
DR   PhylomeDB; Q9LS44; -.
DR   PRO; PR:Q9LS44; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q9LS44; baseline and differential.
DR   Genevisible; Q9LS44; AT.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR006461; PLAC_motif_containing.
DR   PANTHER; PTHR15907; PTHR15907; 1.
DR   Pfam; PF04749; PLAC8; 1.
DR   TIGRFAMs; TIGR01571; A_thal_Cys_rich; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..184
FT                   /note="Protein PLANT CADMIUM RESISTANCE 4"
FT                   /id="PRO_0000407720"
FT   TRANSMEM        96..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   184 AA;  20150 MW;  9D07D3F21AA0BF84 CRC64;
     MGRPGSQPNE AQPPPVQVQP TVNRDNQVHS QNGAIGQANI QTGRPVNNQT QNLWSSDLFD
     CMNDSENAVI TCLAPCVTLG QIAEIVDEGA TPCATGGLLY GMIFFIGVPF VYSCMFRAKM
     RNKYGLPDAP APDWITHLFC EHCALCQEYR ELKHRGFDPN IGWAGNVQAQ QPVMSPPTGQ
     RMMG