ID   PCR6_ARATH              Reviewed;         224 AA.
AC   Q9M9A5;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Protein PLANT CADMIUM RESISTANCE 6;
DE            Short=AtPCR6;
GN   Name=PCR6; OrderedLocusNames=At1g49030; ORFNames=F27J15.18;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Kim C.J., Chen H., Cheuk R., Shinn P., Ecker J.R.;
RT   "Arabidopsis ORF clones.";
RL   Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=15181212; DOI=10.1104/pp.103.037739;
RA   Song W.Y., Martinoia E., Lee J., Kim D., Kim D.Y., Vogt E., Shim D.,
RA   Choi K.S., Hwang I., Lee Y.;
RT   "A novel family of cys-rich membrane proteins mediates cadmium resistance
RT   in Arabidopsis.";
RL   Plant Physiol. 135:1027-1039(2004).
CC   -!- FUNCTION: May be involved in heavy metals transport. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the cornifelin family. {ECO:0000305}.
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DR   EMBL; AC016041; AAF69715.1; -; Genomic_DNA.
DR   EMBL; CP002684; AEE32383.1; -; Genomic_DNA.
DR   EMBL; BT010928; AAR24706.1; -; mRNA.
DR   EMBL; BT011646; AAS47652.1; -; mRNA.
DR   PIR; G96527; G96527.
DR   RefSeq; NP_175332.1; NM_103796.4.
DR   AlphaFoldDB; Q9M9A5; -.
DR   BioGRID; 26551; 4.
DR   IntAct; Q9M9A5; 4.
DR   STRING; 3702.AT1G49030.1; -.
DR   TCDB; 1.A.87.3.5; the mechanosensitive calcium channel (mca) family.
DR   PaxDb; Q9M9A5; -.
DR   PRIDE; Q9M9A5; -.
DR   ProteomicsDB; 236664; -.
DR   EnsemblPlants; AT1G49030.1; AT1G49030.1; AT1G49030.
DR   GeneID; 841326; -.
DR   Gramene; AT1G49030.1; AT1G49030.1; AT1G49030.
DR   KEGG; ath:AT1G49030; -.
DR   Araport; AT1G49030; -.
DR   TAIR; locus:2028526; AT1G49030.
DR   eggNOG; ENOG502SD9M; Eukaryota.
DR   HOGENOM; CLU_077267_0_0_1; -.
DR   InParanoid; Q9M9A5; -.
DR   OMA; NVERRAQ; -.
DR   OrthoDB; 1354725at2759; -.
DR   PhylomeDB; Q9M9A5; -.
DR   PRO; PR:Q9M9A5; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q9M9A5; baseline and differential.
DR   Genevisible; Q9M9A5; AT.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR006461; PLAC_motif_containing.
DR   PANTHER; PTHR15907; PTHR15907; 1.
DR   Pfam; PF04749; PLAC8; 1.
DR   TIGRFAMs; TIGR01571; A_thal_Cys_rich; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..224
FT                   /note="Protein PLANT CADMIUM RESISTANCE 6"
FT                   /id="PRO_0000407722"
FT   TRANSMEM        131..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   224 AA;  24875 MW;  9C71BE360551C683 CRC64;
     MGRPDQTPSP RMNNNFNPVF HAQSEQPVDE KRVLQAEQIY PNNGGVVNQP NQVPMRPGPP
     TYINQSATFN QPYGVSMAGP VHTQPSNWTS GLFDCMNDGE NALITCCFPF VTFGQIAEVI
     DEGATSCGTA GMLYGLICCL FAIPCVYTCT FRTKLRSKYG LPDAPAPDWI THCFCEYCAL
     CQEYRELKNR GLDPSIGWIG NVQKQRMGQQ QEMMAPPMGQ RMMG