ASPH1_MOUSE
ID ASPH1_MOUSE Reviewed; 360 AA.
AC Q2TA57;
DT 18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Aspartate beta-hydroxylase domain-containing protein 1;
DE EC=1.14.11.-;
GN Name=Asphd1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q2TA57-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q2TA57-2; Sequence=VSP_039171;
CC -!- SIMILARITY: Belongs to the aspartyl/asparaginyl beta-hydroxylase
CC family. {ECO:0000305}.
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DR EMBL; AC122863; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC111101; AAI11102.1; -; mRNA.
DR CCDS; CCDS40134.1; -. [Q2TA57-2]
DR CCDS; CCDS85417.1; -. [Q2TA57-1]
DR RefSeq; NP_001034734.1; NM_001039645.1. [Q2TA57-2]
DR RefSeq; NP_001334586.1; NM_001347657.1. [Q2TA57-1]
DR AlphaFoldDB; Q2TA57; -.
DR SMR; Q2TA57; -.
DR STRING; 10090.ENSMUSP00000101946; -.
DR PhosphoSitePlus; Q2TA57; -.
DR MaxQB; Q2TA57; -.
DR PaxDb; Q2TA57; -.
DR PRIDE; Q2TA57; -.
DR ProteomicsDB; 281922; -. [Q2TA57-1]
DR ProteomicsDB; 281923; -. [Q2TA57-2]
DR Antibodypedia; 26891; 55 antibodies from 13 providers.
DR Ensembl; ENSMUST00000052937; ENSMUSP00000049848; ENSMUSG00000046378. [Q2TA57-2]
DR Ensembl; ENSMUST00000106339; ENSMUSP00000101946; ENSMUSG00000046378. [Q2TA57-2]
DR Ensembl; ENSMUST00000106340; ENSMUSP00000101947; ENSMUSG00000046378. [Q2TA57-1]
DR GeneID; 233879; -.
DR KEGG; mmu:233879; -.
DR UCSC; uc009jtn.1; mouse. [Q2TA57-1]
DR UCSC; uc009jto.1; mouse. [Q2TA57-2]
DR CTD; 253982; -.
DR MGI; MGI:2685014; Asphd1.
DR VEuPathDB; HostDB:ENSMUSG00000046378; -.
DR eggNOG; KOG3696; Eukaryota.
DR GeneTree; ENSGT00940000161676; -.
DR HOGENOM; CLU_059279_3_0_1; -.
DR InParanoid; Q2TA57; -.
DR OMA; GQGNWGL; -.
DR OrthoDB; 1324479at2759; -.
DR PhylomeDB; Q2TA57; -.
DR BioGRID-ORCS; 233879; 0 hits in 73 CRISPR screens.
DR PRO; PR:Q2TA57; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q2TA57; protein.
DR Bgee; ENSMUSG00000046378; Expressed in visual cortex and 84 other tissues.
DR Genevisible; Q2TA57; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0051213; F:dioxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0018193; P:peptidyl-amino acid modification; IEA:InterPro.
DR Gene3D; 2.60.120.330; -; 1.
DR InterPro; IPR007803; Asp/Arg/Pro-Hydrxlase.
DR InterPro; IPR027443; IPNS-like_sf.
DR Pfam; PF05118; Asp_Arg_Hydrox; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Dioxygenase; Membrane; Oxidoreductase;
KW Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix.
FT CHAIN 1..360
FT /note="Aspartate beta-hydroxylase domain-containing protein
FT 1"
FT /id="PRO_0000394142"
FT TOPO_DOM 1..45
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 46..68
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 69..360
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..251
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_039171"
SQ SEQUENCE 360 AA; 38266 MW; 2239BB3186C7D23B CRC64;
MWKGGNQEAV IEGSGGELGV PGSWGLQDAA CHLARASLPI MFPWPLPLGS SALTMLLGAL
TSLFLWYCYR LGSQDMQALG TGSRAGGVSG MPDVCSQTGP RGLGDSGEGP RAEGLVSRRL
RAYARRYSWA GMGRVRRAAQ GGSGLTGGAG VMGIQRPGLL FLPDLPSSPF VPRDAQRHDV
ELLQSSFPAI LRDFGAVSWD FSGTTPLPRG WSPPLAPGCY QLLLYQAGRC QPSNCRRCPG
AYRALRGLRS FMSANTFGNA GFSVLLPGAR LEGRCGPTNA RVRCHLGLKI PPGCELVVGG
EPQCWAEGHC LLVDDSFLHT VAHNGSPEDG PRVVFIVDLW HPNVAGAERQ ALDFVFAPDP
