ID   A40_VACCW               Reviewed;         159 AA.
AC   P24765; Q76ZN7;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 2.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Protein A40;
GN   OrderedLocusNames=VACWR165; ORFNames=A40R;
OS   Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain
OS   WR)).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10254;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1856205; DOI=10.1016/s0021-9258(18)92757-2;
RA   Amegadzie B.Y., Ahn B.-Y., Moss B.;
RT   "Identification, sequence, and expression of the gene encoding a Mr 35,000
RT   subunit of the vaccinia virus DNA-dependent RNA polymerase.";
RL   J. Biol. Chem. 266:13712-13718(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2045793; DOI=10.1099/0022-1317-72-6-1349;
RA   Smith G.L., Chan Y.S., Howard S.T.;
RT   "Nucleotide sequence of 42 kbp of vaccinia virus strain WR from near the
RT   right inverted terminal repeat.";
RL   J. Gen. Virol. 72:1349-1376(1991).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Esposito J.J., Frace A.M., Sammons S.A., Olsen-Rasmussen M., Osborne J.,
RA   Wohlhueter R.;
RT   "Sequencing of the coding region of Vaccinia-WR to an average 9-fold
RT   redundancy and an error rate of 0.16/10kb.";
RL   Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   TOPOLOGY, AND SUBCELLULAR LOCATION.
RX   PubMed=10466813; DOI=10.1099/0022-1317-80-8-2137;
RA   Wilcock D., Duncan S.A., Traktman P., Zhang W.H., Smith G.L.;
RT   "The vaccinia virus A4OR gene product is a nonstructural, type II membrane
RT   glycoprotein that is expressed at the cell surface.";
RL   J. Gen. Virol. 80:2137-2148(1999).
CC   -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000305|PubMed:10466813};
CC       Single-pass type II membrane protein {ECO:0000305|PubMed:10466813}.
CC       Note=Not detected in virion membranes.
CC   -!- SIMILARITY: Belongs to the poxviridae A40 protein family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA48336.1; Type=Frameshift; Evidence={ECO:0000305};
CC       Sequence=BAA01813.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; M61187; AAA48336.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; D11079; BAA01813.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; AY243312; AAO89444.1; -; Genomic_DNA.
DR   RefSeq; YP_233047.1; NC_006998.1.
DR   SMR; P24765; -.
DR   IntAct; P24765; 1.
DR   MINT; P24765; -.
DR   DNASU; 3707695; -.
DR   GeneID; 3707695; -.
DR   KEGG; vg:3707695; -.
DR   Proteomes; UP000000344; Genome.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.100.10; -; 1.
DR   InterPro; IPR001304; C-type_lectin-like.
DR   InterPro; IPR016186; C-type_lectin-like/link_sf.
DR   InterPro; IPR016187; CTDL_fold.
DR   Pfam; PF00059; Lectin_C; 1.
DR   SMART; SM00034; CLECT; 1.
DR   SUPFAM; SSF56436; SSF56436; 1.
DR   PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE   1: Evidence at protein level;
KW   Early protein; Host membrane; Lectin; Membrane; Reference proteome;
KW   Signal-anchor; Transmembrane; Transmembrane helix.
FT   CHAIN           1..159
FT                   /note="Protein A40"
FT                   /id="PRO_0000099330"
FT   TOPO_DOM        1..9
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        10..30
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        31..159
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          63..159
FT                   /note="C-type lectin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
SQ   SEQUENCE   159 AA;  18168 MW;  C97B951DEA70EB27 CRC64;
     MNKHKTDYAG YACCVICGLI VGIIFTATLL KVVERKLVHT PSIDKTIKDA YIREDCPTDW
     ISYNNKCIHL STDRKTWEEG RNACKALNPN SDLIKIETPN ELSFLRSIRR GYWVGESEIL
     NQTTPYNFIA KNATKNGTKK RKYICSTTNT PKLHSCYTI