ASPH2_DANRE
ID ASPH2_DANRE Reviewed; 371 AA.
AC A0JMH0;
DT 18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT 12-DEC-2006, sequence version 1.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=Aspartate beta-hydroxylase domain-containing protein 2;
DE EC=1.14.11.-;
GN Name=asphd2; ORFNames=si:ch211-286e11.9, zgc:153516;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the aspartyl/asparaginyl beta-hydroxylase
CC family. {ECO:0000305}.
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DR EMBL; CR388077; CAQ14135.1; -; Genomic_DNA.
DR EMBL; BC125876; AAI25877.1; -; mRNA.
DR RefSeq; NP_001073514.1; NM_001080045.1.
DR RefSeq; XP_005167441.1; XM_005167384.3.
DR AlphaFoldDB; A0JMH0; -.
DR SMR; A0JMH0; -.
DR STRING; 7955.ENSDARP00000077501; -.
DR PaxDb; A0JMH0; -.
DR PeptideAtlas; A0JMH0; -.
DR Ensembl; ENSDART00000083066; ENSDARP00000077501; ENSDARG00000059629.
DR GeneID; 569819; -.
DR KEGG; dre:569819; -.
DR CTD; 57168; -.
DR ZFIN; ZDB-GENE-061103-142; asphd2.
DR eggNOG; KOG3696; Eukaryota.
DR GeneTree; ENSGT00940000159252; -.
DR HOGENOM; CLU_059279_3_0_1; -.
DR InParanoid; A0JMH0; -.
DR OMA; MSLEWLM; -.
DR OrthoDB; 1324479at2759; -.
DR PhylomeDB; A0JMH0; -.
DR TreeFam; TF312799; -.
DR PRO; PR:A0JMH0; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 8.
DR Bgee; ENSDARG00000059629; Expressed in brain and 26 other tissues.
DR ExpressionAtlas; A0JMH0; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0051213; F:dioxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0018193; P:peptidyl-amino acid modification; IEA:InterPro.
DR Gene3D; 2.60.120.330; -; 1.
DR InterPro; IPR007803; Asp/Arg/Pro-Hydrxlase.
DR InterPro; IPR027443; IPNS-like_sf.
DR Pfam; PF05118; Asp_Arg_Hydrox; 1.
PE 2: Evidence at transcript level;
KW Dioxygenase; Membrane; Oxidoreductase; Reference proteome; Signal-anchor;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..371
FT /note="Aspartate beta-hydroxylase domain-containing protein
FT 2"
FT /id="PRO_0000394143"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..42
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 43..371
FT /note="Lumenal"
FT /evidence="ECO:0000255"
SQ SEQUENCE 371 AA; 41131 MW; 45FED86416441B06 CRC64;
MEWSLERMRE WVAGGMQSVR ECESSALGTA LCLALLFIWY CYRVGCEHTS PSLRGGFSPE
PRVGAVPGVL ASELSSRGGS SKLRQIGGVG GGGVSDEELN GFAYCQSSEC FRCTKPGEGL
NQRLYHSLQE YAKRYTWAGM GRVHKGVREQ GRYLLCSRPS IQKPEVFFLP DLPSAPFFSR
EAQKHDVELL ERSFPALLAE FESVYRLPSS RTGSSLPPGW KANSTPRGQW WTFYLVNQGT
PMVLNARRCP RTWRVLGQLR TFIANNVFGN ACFSVLSPGS TITEHYGPTN VRLRCHLGLK
VPSGCELVVG GEPQCWSEGS CLLFDDSFLH TAFHDGSAED GPRAVFMVDL WHPNVAAAER
QALDYIFTPG R
