ID   ASPH_ASPFU              Reviewed;         139 AA.
AC   Q00050; Q4WFY6;
DT   01-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 2.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=Asp-hemolysin;
DE            Short=Asp-HS;
DE   Flags: Precursor;
GN   ORFNames=AFUA_3G00590;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Fresenius-Muramatsu;
RX   PubMed=8086452; DOI=10.1016/0167-4781(94)90258-5;
RA   Ebina K., Sakagami H., Yokota K., Kondo H.;
RT   "Cloning and nucleotide sequence of cDNA encoding Asp-hemolysin from
RT   Aspergillus fumigatus.";
RL   Biochim. Biophys. Acta 1219:148-150(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- SIMILARITY: Belongs to the aegerolysin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA03951.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; D16501; BAA03951.1; ALT_FRAME; mRNA.
DR   EMBL; AAHF01000010; EAL86341.1; -; Genomic_DNA.
DR   PIR; S47523; S47523.
DR   RefSeq; XP_748379.1; XM_743286.1.
DR   AlphaFoldDB; Q00050; -.
DR   SMR; Q00050; -.
DR   EnsemblFungi; EAL86341; EAL86341; AFUA_3G00590.
DR   GeneID; 3505795; -.
DR   KEGG; afm:AFUA_3G00590; -.
DR   VEuPathDB; FungiDB:Afu3g00590; -.
DR   eggNOG; ENOG502SSEK; Eukaryota.
DR   HOGENOM; CLU_115909_0_0_1; -.
DR   InParanoid; Q00050; -.
DR   OMA; CPWGSKT; -.
DR   OrthoDB; 1564258at2759; -.
DR   Proteomes; UP000002530; Chromosome 3.
DR   GO; GO:0030169; F:low-density lipoprotein particle binding; IDA:AspGD.
DR   GO; GO:0019836; P:hemolysis by symbiont of host erythrocytes; IDA:AspGD.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
DR   InterPro; IPR009413; Aegerolysin-typ.
DR   Pfam; PF06355; Aegerolysin; 1.
DR   PIRSF; PIRSF007951; PIRSF007951; 1.
PE   2: Evidence at transcript level;
KW   Cytolysis; Hemolysis; Reference proteome.
FT   PROPEP          1..5
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000000997"
FT   CHAIN           6..139
FT                   /note="Asp-hemolysin"
FT                   /id="PRO_0000000998"
FT   REGION          47..79
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        50..79
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        27
FT                   /note="Q -> K (in Ref. 1; BAA03951)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   139 AA;  15199 MW;  7AC72493C977782C CRC64;
     MASVQAYAQW VTVHLINSMS SETLSIQNAS LSWGKWYKDG DKDAEITSED VQQKTAPPGG
     SVNVNSCGRS DASSGTTGGF DLYDGNTKIG RVHWDCPWGS KTNDFDVGER NKNYWVEIGT
     WNKYGGAIGT VDVEVGRKR