ASPM_AOTVO
ID ASPM_AOTVO Reviewed; 3473 AA.
AC P62283;
DT 05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 23-FEB-2022, entry version 80.
DE RecName: Full=Abnormal spindle-like microcephaly-associated protein homolog;
GN Name=ASPM;
OS Aotus vociferans (Spix's owl monkey) (Noisy night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=57176;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=14722158; DOI=10.1093/hmg/ddh055;
RA Evans P.D., Anderson J.R., Vallender E.J., Gilbert S.L., Malcom C.M.,
RA Dorus S., Lahn B.T.;
RT "Adaptive evolution of ASPM, a major determinant of cerebral cortical size
RT in humans.";
RL Hum. Mol. Genet. 13:489-494(2004).
RN [2]
RP COMMENTS ON AOTUS SPECIES.
RA Evans P.D.;
RL Unpublished observations (JUN-2004).
CC -!- FUNCTION: Probable role in mitotic spindle regulation and coordination
CC of mitotic processes. May have a preferential role in regulating
CC neurogenesis (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC Note=The nuclear-cytoplasmic distribution could be regulated by the
CC availability of calmodulin. {ECO:0000250}.
CC -!- CAUTION: PubMed:14722158 sequence has been obtained from a monkey
CC phenotypically consistent with Aotus vociferans, but karyotype
CC information confirming the phenotype was not available. {ECO:0000305}.
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DR EMBL; AY485422; AAR98743.1; -; mRNA.
DR PRIDE; P62283; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007051; P:spindle organization; IEA:InterPro.
DR Gene3D; 1.10.418.10; -; 2.
DR Gene3D; 1.25.10.10; -; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR031549; ASH.
DR InterPro; IPR029955; ASPM.
DR InterPro; IPR001715; CH-domain.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR22590:SF4; PTHR22590:SF4; 6.
DR Pfam; PF15780; ASH; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00612; IQ; 40.
DR SMART; SM00033; CH; 1.
DR SMART; SM00015; IQ; 65.
DR SUPFAM; SSF47576; SSF47576; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR SUPFAM; SSF52540; SSF52540; 17.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50096; IQ; 36.
PE 2: Evidence at transcript level;
KW Calmodulin-binding; Cell cycle; Cell division; Coiled coil; Cytoplasm;
KW Mitosis; Nucleus; Phosphoprotein; Repeat.
FT CHAIN 1..3473
FT /note="Abnormal spindle-like microcephaly-associated
FT protein homolog"
FT /id="PRO_0000191325"
FT DOMAIN 916..1052
FT /note="Calponin-homology (CH) 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT DOMAIN 1106..1257
FT /note="Calponin-homology (CH) 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT DOMAIN 1343..1374
FT /note="IQ 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1389..1418
FT /note="IQ 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1578..1607
FT /note="IQ 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1628..1657
FT /note="IQ 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1651..1680
FT /note="IQ 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1724..1753
FT /note="IQ 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1747..1778
FT /note="IQ 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1797..1826
FT /note="IQ 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1820..1849
FT /note="IQ 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1870..1899
FT /note="IQ 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1893..1924
FT /note="IQ 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1943..1974
FT /note="IQ 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2016..2045
FT /note="IQ 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2039..2070
FT /note="IQ 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2089..2120
FT /note="IQ 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2112..2143
FT /note="IQ 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2162..2193
FT /note="IQ 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2235..2266
FT /note="IQ 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2258..2289
FT /note="IQ 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2307..2338
FT /note="IQ 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2330..2361
FT /note="IQ 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2380..2411
FT /note="IQ 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2403..2434
FT /note="IQ 23"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2453..2484
FT /note="IQ 24"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2526..2557
FT /note="IQ 25"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2661..2690
FT /note="IQ 26"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2684..2715
FT /note="IQ 27"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2734..2763
FT /note="IQ 28"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2810..2841
FT /note="IQ 29"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2855..2886
FT /note="IQ 30"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2905..2934
FT /note="IQ 31"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2928..2959
FT /note="IQ 32"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2950..2981
FT /note="IQ 33"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 3025..3054
FT /note="IQ 34"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 3075..3106
FT /note="IQ 35"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 3177..3206
FT /note="IQ 36"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT REGION 475..511
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1053..1074
FT /evidence="ECO:0000255"
FT MOD_RES 280
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 283
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 366
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 391
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 424
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 604
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 1099
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
SQ SEQUENCE 3473 AA; 409242 MW; 2113D6FEB0EE4D43 CRC64;
MATRRVGRGC WEVSPTERRP CAGLRGPAAE EEAASPPVLL LSHFCRSPFL CFGDVRLGAS
RTLPLTLDNP NEEVAEVKIS HLPAADLGFS VSQRCFVLQP KEKIVISVNW TPFKEGRVRE
IMTFLVNDVL KHQAILLGNA EEQKKKKRNL WDTIKKKKIS ASTSHKRRVS NIQNVNKTFS
VSQKVDRVRS PLQACENLAM NEGGPPTENN YLTLEENKIL ISPISPTFNE CHGATCLPLS
VRRSTAYSSL HASENRELLN VDSASVSKDD FNEKVVSETS FNSINVNDQS GENNKLILTP
NCSTLNITQS QRSFLSPDSF VNNSHGDNNE LELGTCLSSD MFMKDNSKPV HLESTTAHEI
YQKILSPDSF IKDNYGLNQD LESESINSIL SPNQFLKDSM ACMHTSQQTC KVTLSNENSQ
VPQSLQDWRK SEVFPCIPEC QGSKSPKATF EELVEMKSNC CSFIKQNQPK FPAVKDISSH
SHNKQPKRRP ILSATVTKRK PTCPRENQTE INKPKAKRCL NSAVGENEKI INNQKEKEDF
HSYLPIIDPV LSKSKSYKNE ITPSLTTASV ARKRKSDGSM GDANVRVAVT EHTEVREIKR
IHFSPFECKT STVKKTKNVV TPILKRISNR EKLSLKKKTE FKTPIFKTSK RTKPIIAVAQ
SNLTFIKPLK TGIPRHPMPF AAKNMFYDER WKEKQEQGFT WWLNFILTPD DFTVKTNISE
VNAATLLLGL ENQHKISVPR APTKEEMSLR AYTARCRLNR LRRAACRSFT SEKMVKAIKK
LEIEIEARRL IVRKDRHLWK DVGERQKVLN WLLSYNPLWL RIGLETIYGE LISLEDNSDV
TGLAVFILNR LLWNPDIAAE YRHPTVPHLY RDGHEEALSK FTLKKLLLLV CFLDYAKISR
LIDHDPCLFC KDAEFKASKE ILLAFSRDFL SGEGDLSRHL GLLGLPVNHV QTPFDEFDFA
VANLAVDLQC GVRLVRTMEL LTQNWDLSKK LRIPAISRLQ KMHNVDIVLQ VLKSRGIELS
DEHGNTILSK DIVDRHREKT LGLLWKIAFA FQVNISLNLD QLKEEIAFLK HTKSIKKTVS
LSSCQSDALT NKKKGKRDSG SFEQYGENIK LLMDWVNAVC AFYNKKVENF TVSFSDGRVL
CYLIHHYHPC YVPFNAICQR TTQTVECTQT GSVVLNSSSE SDESSLDMSL KAFDQENTSE
LYKELLENEK KNFHLVRSAV RDLGGIPAMI NHSDMSNTIP DEKVVITYLS FLCARLLDLR
KEIRAARLIQ TTWRKYKLKT DLKRHQERDK AARIIQSAVI NFLTKQRLRK KLNAALVIQK
YWRRVLAQKK LLMLKKEKLE RVQNKAASLI QGYWRRYSTR KRFLKLKYYS VILQSRIRMI
IAVTCYKRYL WAAVTIQRHW RAYLRRKQDQ QRYEMLKSSS LIIQAMFRRW KRRKMQLQVK
ATITLQRAFR EWHLRKRAKE EKSAIVIQSW YRMHKQLQKY VYVRSCVVII QKRFRCFQAQ
KLYKRRKESI LTIQKYYRAY MKGKIERTNY LQKRAAAIQL QAAFRRLKAH NLHRKIRAAC
VIQSYWRMRQ DRVRFLNLKK IIIKLQAHVR KHQQLQKYKK MKKAAVTIQT HFQAYIFARK
VLASYQKTRS AVIVLQSAYR GMQARKMYIH ILTSVIKIQS YYRAYVSKKE FLSLKNATVK
LQSIVKMKQT RKQYLHLRAT VLFIQRCYRS KKLAAQKREE YMQMRESCIK LQAFVRGYLV
RKQMRLQRKA VISLQSYFRM RKARQYYLKM YKAVIIIQNY YHSYKAQVNQ RKNFLQVKKA
ATCLQAAYRG YKVRQLIKQQ SIAAVKIQSA FRGYRKRVKY QSVLQSIIKI QRWYRAYKTL
SDIRTHFLKT KAAVISLQSA YRGWKVRKQI RREHQAAMKI QSAFRMAKAQ KQFRLFKTAA
LVIQQHLRAW TAGRKQRMEY IELRHSVLML QSMWKGKTLR RQLQRQHKCA VIIQSYDRMH
VQQKKWKIMK KAVLLIQKYY RAYSIGREQH HLYLKTKAAV VTLQSAYRGM KVRKRIKDCN
KAAITIQSKY RAYKTKKKYA ACRASAIIIQ RWYRGIKITN HQYKEYLNLK KTAIKIQAVY
RGIRVRRHIQ HMHRAATFIK AMFKMHQSRI RYHTMRKATI VIQVRYRAYY QGKMQRENYL
KILKAVNVLQ ANFRGVRVRR TLRKLQIAAT LIQSNYRRYR QQTYFNKLKK ITKTVQQRYR
AVKERNIQFQ RYNKLRHSVI HIQAIFRGMK ARRHLKTMHI AATLIQRRFR TLMMRRRFLS
LKKTAIWVQR KYRAHLCTKH HLQFLRLQNA AIKIQSSYRR WMIRKKIREM HRAATFIQAT
FRMHRVHMRY QALKQASVVI QQQYQANRAA KLQRQHYLRQ RHSAVILQAA FRGMKTRRHL
KSMHSSAILI QSRFRSLLVR RRFISLKKAA IFIQRKYRAT ICAKHKLHQF LQLRKAAITI
QSSYRRLMVK KKLQEMHRAA VLIQATFRMH RTYITFQTWK HASILIQQHY RTYRASKLQR
ENYTKQWHSA VIIQAAYRGM KARQLLREKH KAAIIIQSTY RMYRQCCLYQ KLQWATKIIQ
EKYRANKKKH KALQHNELKK AETCLQASFQ DMNIKLIQEQ DQTSIIIQKH CKAFKIKKHY
LHLRAPVVSI QRRYRKLTAV RTQAVICIQS YYRGFKVRRD IQNMHLAATR IQSFYRMHRA
TVDYQTKKTA VVLIQNYYRL YVRVKTERKS FLAVQKSVRT IQAAFRGMKV RQKLKNVSQE
KMAAIVNQSA LCCYRSKAQY EAVRSEGVII QEWYKASCLA CSQEAEYHSQ SRAAVTIQKA
FRRMITRKVE TQKCAALRIQ FFLQMAVYRR RFVQQKRAAV TLQHYFRMWQ TRKQFLLYRK
AAVVLQNHYR AFLSAKHQRQ VYLRIRSSVI IIQARIKGFI QKRKFQKIRN STIKIQAMWR
RYRAKKSLCK VKAACKIQAW YRCWRAHKEY LAILKAVKII QGCFYTKLER TRFLNLRASA
IIIQRKWRAI LSAKIAHEHF LMIQRHRAAC LIQAHFRGYK GRQVFLRQKS AALNIQKYIR
AREAGRRERI KYIELKKSTV ILQALVRGWL VRKRILEQRA KIRLLHFTAA AYYHLKALRI
QRAYKLYLAL KKANKQINSV ICIQRWFRAR LQQKRFIQKC HSIKKIEHEG QERLSQQNRA
ASVIQKAVRH FLLRRKQEKF TSGIIKFQAL WRGYSWRKNN DCTKIKAIRL SLQVVNREIR
EENKLYRRTA LALHYLLTYK HLSAILEAVK HLEVVTRLSP LCCENMAQSG AISKIFVLIR
SCNRSVPCME VIRYAVQVLL NVAKYEKTTS AVYDVENCVD TLLELLQMYR EKPGNKVADK
SGSIFTKTCC LLATLLKTTN RASDVRSRSK VVDRIYSLYK LTACKHKVNT ERLLYKQKKD
SSISIPFIPE TPVRTRIVSR LKPDWVLRRD NLEEIINPLQ AIQMLMDTLG IPY
