ASPM_ATEGE
ID ASPM_ATEGE Reviewed; 1564 AA.
AC P62284;
DT 05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 62.
DE RecName: Full=Abnormal spindle-like microcephaly-associated protein homolog;
DE Flags: Fragment;
GN Name=ASPM;
OS Ateles geoffroyi (Black-handed spider monkey) (Geoffroy's spider monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Atelidae;
OC Atelinae; Ateles.
OX NCBI_TaxID=9509;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=15045028; DOI=10.1371/journal.pbio.0020126;
RA Kouprina N., Pavlicek A., Mochida G.H., Solomon G., Gersch W., Yoon Y.-H.,
RA Collura R., Ruvolo M., Barrett J.C., Woods C.G., Walsh C.A., Jurka J.,
RA Larionov V.;
RT "Accelerated evolution of the ASPM gene controlling brain size begins prior
RT to human brain expansion.";
RL PLoS Biol. 2:653-663(2004).
CC -!- FUNCTION: Probable role in mitotic spindle regulation and coordination
CC of mitotic processes. May have a preferential role in regulating
CC neurogenesis (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC Note=The nuclear-cytoplasmic distribution could be regulated by the
CC availability of calmodulin. {ECO:0000250}.
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DR EMBL; AY497018; AAS48533.1; -; Genomic_DNA.
DR AlphaFoldDB; P62284; -.
DR SMR; P62284; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007051; P:spindle organization; IEA:InterPro.
DR InterPro; IPR029955; ASPM.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR22590:SF4; PTHR22590:SF4; 5.
DR Pfam; PF00612; IQ; 34.
DR SMART; SM00015; IQ; 49.
DR SUPFAM; SSF52540; SSF52540; 15.
DR PROSITE; PS50096; IQ; 31.
PE 3: Inferred from homology;
KW Calmodulin-binding; Cell cycle; Cell division; Cytoplasm; Mitosis; Nucleus;
KW Repeat.
FT CHAIN <1..>1564
FT /note="Abnormal spindle-like microcephaly-associated
FT protein homolog"
FT /id="PRO_0000191326"
FT DOMAIN 31..60
FT /note="IQ 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 220..251
FT /note="IQ 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 270..299
FT /note="IQ 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 293..322
FT /note="IQ 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 366..395
FT /note="IQ 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 389..420
FT /note="IQ 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 439..468
FT /note="IQ 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 462..491
FT /note="IQ 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 512..541
FT /note="IQ 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 535..566
FT /note="IQ 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 608..639
FT /note="IQ 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 658..687
FT /note="IQ 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 681..712
FT /note="IQ 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 731..762
FT /note="IQ 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 754..785
FT /note="IQ 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 804..835
FT /note="IQ 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 827..856
FT /note="IQ 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 877..908
FT /note="IQ 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 900..931
FT /note="IQ 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 949..980
FT /note="IQ 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 972..1003
FT /note="IQ 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1022..1053
FT /note="IQ 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1045..1076
FT /note="IQ 23"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1095..1126
FT /note="IQ 24"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1168..1199
FT /note="IQ 25"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1304..1333
FT /note="IQ 26"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1327..1358
FT /note="IQ 27"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1377..1406
FT /note="IQ 28"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1452..1483
FT /note="IQ 29"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1474..1503
FT /note="IQ 30"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1500..1531
FT /note="IQ 31"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT NON_TER 1
FT NON_TER 1564
SQ SEQUENCE 1564 AA; 189406 MW; 200F29D595B66CDB CRC64;
TRKRFLKLKY YSIILQSRIR MIIAVTSYKR YLWATVTIQR HWRAYLRRKQ DQQRYEMLKS
SSLIIQAMFR RWKQRKMQLQ VKATITLQRA FREWHLRKRA KEEKSAIVIQ SWYRMHKQLR
KYVYVRSCVV IIQKRFRCFQ AQRLYKRKRE SILTIQKYYR AYLKGKIERI HYLQKRAAAI
QLQAAFKILK AHNLHRPIRA ACVIQSYWRM RQDRVRFLNL KKNIIKLQAH VRKHQQLQKY
KKIKKAAVII QTHFQAYIFA RKVLASYQKT RSAVIVLQSA YRGMQARKMY IHILTSVIKI
QSYYRAYVSK KEFLSLKNAT IKLQSIVKMK QTRKQYVHLR ATALFIQQCY HSKKLAAQKR
EEYMQMRESC IKLQAFVRGY LVRKQIRLQR KAVISLQSYF RMRKARQYYL KMYKAVIIIQ
NYYHSYKAQV NQRKNFLRVK KAATCLQAAY RGYKVRQLIK QQSVAAVKIQ SAFRGYSKRV
KYLSVLQSII KIQRWYRAYK TLYDIRTRFL KAKAAVISLQ SAYRGWKVRK QIRREHQAAM
KIQSAFRMAK AQKQFRLFKT AALVIQQHLR AWIAGRKQRM EYIELRHSVL MLQSMWKGKT
LRRDLQRQHT CAVIIQSYYR MHVQQKKWKI MKEAALLIQK YYRACRIGRE QHCLYLETKA
AVLTLQSAYR GMKVRKRIKA CNTAAITIQS KYRAYKTKKK YAAYRASAII IQRWYRGIKI
TNHQYKEYLN LKKTAIKIQA VYRGIRVRRH IQHMHRAATF IKAMFKMHQP RIRYHTMRKA
TIVIQVRYRA YHQGKMQREN YLKILKAVNI LQANFRGVRV RRTLRKLRIA ATLIQSNYRR
YRQQTYFNKL KKITRTVQQR YRAVKERNIQ FQRYNKLRHS VIYIQALFRG MKARRHLKTM
HIAATLIQRR FRALMLRRRF LSLKKTAIWI QRKYRAHLRT KRHLQFLRLQ NAAIKIQSSY
RRWMIRKKMR EMHRAAAFIQ ATFRMHRVHM RYHALKQASV VIQQRYQANR AAKLQRQHYL
RQRYSAVILQ AAFRGMKTRR HLKSMYFSAI LIQSRFRSLL VRRRFISLKK AAIFIQRKYR
ATICAKHKLR QFLQLRKAAI TIQSSYRRLM VKKKLQEMHR AAVLIQATFR MHRTHITFQT
WKHASILIQQ HYRTYRASKL QRENYTKQWH SAVIIQAAYR GMKARQLLRE KHKAAIIIQS
TYRMYRQYCL YQKLQWATKI IQEKYRADKK KHKALQHTEL RKAETCVQAS FQDVNIEKLI
QEQHQTSIII QKHCKAFKIK KHYLHLRAPV VSIQRRYGKL TAVHTQAVIC IQSYYRGFKV
RRDIQNMHLA ATRIQSFYRM HRAKVHYQTK KTAIVIIQNY YRLYVRVKTE RKSFLAVQKS
VRTIQAAFRG MKVRQKLKNI PKEKMAAIVD QSALYCYRSK GQDEAVRSEG VIIQEWCKAS
CLACSQEEYH SQSRAAVTIQ KAFRRMITRK LETQKCATLR IQSFLRMAVY RRRRANSVQQ
KRAAVTLQHY FRMWQTRKQF LLYRKAAVVL QNHYRAFLSG KHQRQVYLQI RSSVIIIQAR
IKGF
