ASPM_BOVIN
ID ASPM_BOVIN Reviewed; 3371 AA.
AC P62285;
DT 05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 23-FEB-2022, entry version 105.
DE RecName: Full=Abnormal spindle-like microcephaly-associated protein homolog;
DE Flags: Fragment;
GN Name=ASPM;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=14722158; DOI=10.1093/hmg/ddh055;
RA Evans P.D., Anderson J.R., Vallender E.J., Gilbert S.L., Malcom C.M.,
RA Dorus S., Lahn B.T.;
RT "Adaptive evolution of ASPM, a major determinant of cerebral cortical size
RT in humans.";
RL Hum. Mol. Genet. 13:489-494(2004).
CC -!- FUNCTION: Probable role in mitotic spindle regulation and coordination
CC of mitotic processes. May have a preferential role in regulating
CC neurogenesis (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton,
CC spindle {ECO:0000250}. Nucleus {ECO:0000250}. Note=The nuclear-
CC cytoplasmic distribution could be regulated by the availability of
CC calmodulin. Localizes to spindle poles during mitosis (By similarity).
CC {ECO:0000250}.
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DR EMBL; AY485424; AAR98745.1; -; mRNA.
DR STRING; 9913.ENSBTAP00000010340; -.
DR PaxDb; P62285; -.
DR PRIDE; P62285; -.
DR eggNOG; KOG0165; Eukaryota.
DR InParanoid; P62285; -.
DR OrthoDB; 482623at2759; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000922; C:spindle pole; IBA:GO_Central.
DR GO; GO:0005516; F:calmodulin binding; IBA:GO_Central.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0051295; P:establishment of meiotic spindle localization; IBA:GO_Central.
DR GO; GO:0000278; P:mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0007051; P:spindle organization; IBA:GO_Central.
DR Gene3D; 1.10.418.10; -; 2.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR031549; ASH.
DR InterPro; IPR029955; ASPM.
DR InterPro; IPR001715; CH-domain.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR22590:SF4; PTHR22590:SF4; 6.
DR Pfam; PF15780; ASH; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00612; IQ; 40.
DR SMART; SM00033; CH; 1.
DR SMART; SM00015; IQ; 64.
DR SUPFAM; SSF47576; SSF47576; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR SUPFAM; SSF52540; SSF52540; 15.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50096; IQ; 40.
PE 2: Evidence at transcript level;
KW Calmodulin-binding; Cell cycle; Cell division; Coiled coil; Cytoplasm;
KW Cytoskeleton; Mitosis; Nucleus; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN <1..>3371
FT /note="Abnormal spindle-like microcephaly-associated
FT protein homolog"
FT /id="PRO_0000191327"
FT DOMAIN 852..988
FT /note="Calponin-homology (CH) 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT DOMAIN 1042..1193
FT /note="Calponin-homology (CH) 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT DOMAIN 1198..1227
FT /note="IQ 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1396..1427
FT /note="IQ 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1469..1500
FT /note="IQ 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1564..1593
FT /note="IQ 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1587..1616
FT /note="IQ 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1610..1639
FT /note="IQ 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1644..1673
FT /note="IQ 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1667..1698
FT /note="IQ 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1717..1746
FT /note="IQ 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1740..1769
FT /note="IQ 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1790..1819
FT /note="IQ 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1813..1844
FT /note="IQ 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1863..1894
FT /note="IQ 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1886..1917
FT /note="IQ 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1936..1965
FT /note="IQ 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1959..1990
FT /note="IQ 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2009..2040
FT /note="IQ 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2032..2063
FT /note="IQ 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2082..2113
FT /note="IQ 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2105..2134
FT /note="IQ 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2155..2186
FT /note="IQ 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2227..2258
FT /note="IQ 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2250..2281
FT /note="IQ 23"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2300..2331
FT /note="IQ 24"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2323..2354
FT /note="IQ 25"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2396..2427
FT /note="IQ 26"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2446..2477
FT /note="IQ 27"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2539..2570
FT /note="IQ 28"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2580..2609
FT /note="IQ 29"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2603..2634
FT /note="IQ 30"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2653..2682
FT /note="IQ 31"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2729..2760
FT /note="IQ 32"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2751..2780
FT /note="IQ 33"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2824..2853
FT /note="IQ 34"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2847..2878
FT /note="IQ 35"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2869..2900
FT /note="IQ 36"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2944..2973
FT /note="IQ 37"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2994..3025
FT /note="IQ 38"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 3096..3125
FT /note="IQ 39"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 3119..3150
FT /note="IQ 40"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT COILED 989..1014
FT /evidence="ECO:0000255"
FT MOD_RES 212
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 215
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 300
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 325
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 540
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 1035
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT NON_TER 1
FT NON_TER 3371
SQ SEQUENCE 3371 AA; 395870 MW; 71D6AA7E1E507F6A CRC64;
PNEEAAAVWL SHGPAAERGF TIWPSAFVLQ PKEKIVVSIT WTPLKGGRIR ETITFLVNDI
LKHQAILLGN AEEPKKKKRT LWDTINKKKA SASSRHNKKA SNIQNVNKTF NVSPKADRVR
SPLQACENLA TNGNCSPPES NPLILEENKL PISPISPASQ ECHRGTCLPL PVRRSTTYTS
LPASENGGLV KADGANTAED FHFNEKGITE TSFDSIDNVN SQIEENGKLT LTPNYSSSLN
ITQSQGHFLS PDSFVNNSHA SNNEPEFVKC LSPDMFVKGN TRPVILESKR VHEICRKILS
PDSFINDNYG LNEDLETESI NPILSPNQFL KDNMAYICVS QQTCQLPLST GHFQDSQPPQ
DERKNAAVPC ISECQQLESP KATFEASKAL EVMSNSYTFK KQNQPKFSAV QDISSHSRKK
PIKRRPILSA TVTKRKPTCA VENQMETVKP KAKRCLNVVV GDCXKETDDQ KEKDDFHPFL
PIRDLIXXRP KSSKNIVTPP CKVASVARKR KSEGHTGDEN VRITVTECXE XQEVKRPHFS
PVESKTSTVK HTKKVVTSSL KRVSHREKLN LKKKTDSLGY RTPKTNRRTR PFVPVAQSNL
TFIKPLKGIP RHPMPFAAKN MFYDERWKEK QEQGFTWWLN FILTPDDFTV KTNISEVNAS
TLLLGVESQH KVSVPKAPTK DEVSLRAYTA RCRLNRLRRA ACRLFTSEKM VKAMKKLEIE
IEARRLIVRK DRHLWKDVGE RQKVLNWLLS YNPLWLRIGL ETIYGELVPL EDNSDVTGLA
MFILNRLLWN PDIAAEYRHP SVPHLYRDGH EEALSKFTLK KLLLLICFLD YAKISRLIDH
DPCLFCKDAE FKASKEILLA FSRDFLGGEG DLSRHLSLLG FPVTHVQMPF DEFDFAVKNL
AVDLQCGVRL VRTMELLTQN WNLSKKLRIP AISRLQKMHN VDIVLEILKS RGIQLNDEHG
NAILSKDIVD RHREKTLALL WKIALAFQVD ISLNLDQLKE EIDFLKNTQS MKKTMSALSC
RPDAVISKKR DERHSGPFEQ CSESVKLLMD WVNAVCGFYN KKVENFTVSF SDGRVLCYLI
HHYHPCYVPF DAICQRTTQT VECTHTGSVV LNSSSESDGS FLDFSLKPPD QENTSELYKE
LLENEKKNFQ LVRSAARDLG GIPAMIHHSD MSNTIPDEKV VITYLSFLCA RLLDLRKETR
AARLIQTTWR QYKLKKDLKH HQERDKAARI IQSAIINFLT KQRFKKKVSA ALVIQKYWRR
ALAKRKLLML KKEKLERVHS KSASIIQRHW RRYSTRKQFL KLKYYSIFLQ SKIRMIIAVA
SYKRYHWATV TIQRRWRAHV RSKQDRQRYE LLRSSTLVIQ FAFRRWRRRK RQSQINAAIT
LQRAFRQWRV QKCAQEERAA VVIQSWYRMH RELRKYIHLR SCVIIIQARF RCFQAQKLYT
RTRESILTLQ KHYRAYVKGK VERTGYLQKR AAAIRLQAAF RGRRARNLCR QIKAACVLQS
YWRMRQDRLR FLNLKKNIIR LQAHIRRRQQ LHTYQKMKKA ALIIQIHFRA YMSAKEVLAS
YQKTRSAVIV LQSACRRMQA RKKFLHILTS IVKIQSYYRA YASRRKFLRL KKATVKLQSI
VRMKLARKQY LHLRAIAQQR EEHRRASCIK LQAFLRGYLV RKQVRLQRKA AVSLQSYFRM
RKMRLDYLKV CHAAVVIQRY YRAHRAGAQQ RKHFLQVRRA VTYLQATYRG YKVRRQLQQQ
SAAALKIQAA FRGYRQRTKY QSVLQSALKI QRWYRTHKTV SAIRSHFFKT RTAAISLQSA
YRGWKVRKQM RKEHEAAVKI QSAFRTARAQ KEFRVLKTAA SVIQQHLRAR AAGRRQRTEY
TALRRAAVML QSAWRGRAAR RRIQKQQRCA IIIQAYYRRH VQQKRWEIMK KAAHLIQMHY
RAYRTGRKQH HLFLKTKXAA IILQSAFRGV RVRKKVKEMH QAAATIQSRY RAYQARKKYA
SYRAAAVIIQ RWYRAAKLAG RQREEYLAVK KAALKIQAVY RGVRARRHIR RMHMAATLIK
AAFKMQQSRR RYQQMRTAAI IIQVRYRAYC QGRAQRAKYL MILKAVALLQ AALRGARVRQ
SLRRMRTAAT LIQAHYRGRR QQAYFNKLKK VTKTVQQKYR AARERHAQLR RYNQLRRSAI
CIQAAFRGMR ARRRLKAMHS AAAVIQRRFR TLGMRRRFLS LRKTAVWVQR KYRAKVCTRH
HVQQLRLQKA AIKIQSWYRG WMVRKKIQEM RRAATVLQAA FRRHRTRARY QAWRCASQVI
QQRFRAGRAA RLQRRQYLQQ RHSALVLQAA FRGMRVRRRL KRMHASATLI QSRFRSIMMR
KRFLSLKKAA VFVQRKYRAT ICAKHHLHQF LELQKAIIII QASYQRRMVK KQLQEMHRAA
ALIQASFRMH RARLAFQTWK HAAVLIQQRY RACRAAKLQR ALYIRWRHSA VVIQAAYKGL
KARQLLREKH RAAVIIQSTY RMYRQHFFYQ KLQWATKVIQ ERYRASKRKA LQHDALKAAT
CARAGFQDMV VRRLIEERRH QAAITIQEHF RAFKTRKHYL HFRAKVVFVQ RRYRELMAVR
TQAVICIQSC FRGFKARRGI QRMHLAATRI QSCYRRHRAR ADYQAKKRAV VVIQNHYRSY
IRVKMERKEF LAIQKSARTI QAAFRGMKVR QKLKTMPDKK MAAPATQPAF YCHRTESQHE
AGESPALVAQ GLYKTSLVGP SQETEQHSQR KAAVTIQKAF RKMVTRRLEK QRRAAVRIQS
FLQMAVYRRR FLQQKRAALT LQRCFRTQQS RKQFLLYREA AVGLQNPHRT SLPAKHQREL
YLQIRSSVII IQARVKGFIQ KRKFRELKDS TIKIQAVWRR HKARKYLREV KAACRIQAWY
RCWKARREYL AVLRAVRIIQ RCFCXQQQRR RFLNVRASAV IIQRRWRTVL SGRTTHEQSL
MTKRHQAACL IQANFRGYKA RQAFLQQKSA ALTIQRYIRA RKAGKHQRMK YVELKKSTVV
LQALVRGWLV RKRISEQRAK IRLLHFAAAA FYHLSALRIQ RAYRRHVALK HANNKQLNSA
ICIQRWFRAR SQRKRFLQKY SIINIQREAR EQARQHSRAA SVIQRAVRRF LLRKKQENFN
KRIAKIQALW RGYSWRKKND STKTKAIRQR LQCVNREIRE ESKLYHRTAV ALHHLLTYKY
LSTVLEALKH LEAVTRLSSI CCEKMAQSGA ISKIFVLIRS CNRSVPCMEV IRYAMQVLLN
VAKYEKTTSA IYDVENCVDT LLELMQMYQE KSGDKVADKS RSIFTKTCCL LAVLLKTTTR
ALDVQSRSKV VDRIYSLYKL TAHKHKVNTE RILCKQKKNS SVSLSFFPET PVRTTMVSRL
KPDWVLRRDN V
