PCX1_MOUSE
ID PCX1_MOUSE Reviewed; 2344 AA.
AC Q9QYC1; Q6ZQ41; Q9CUU7;
DT 03-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Pecanex-like protein 1;
DE AltName: Full=Pecanex homolog protein 1 {ECO:0000250|UniProtKB:Q96RV3};
GN Name=Pcnx1 {ECO:0000250|UniProtKB:Q96RV3}; Synonyms=Kiaa0805, Pcnx, Pcnxl1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 594-2344 (ISOFORM 2).
RC TISSUE=Embryonic tail;
RX PubMed=14621295; DOI=10.1093/dnares/10.4.167;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: III.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:167-180(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 880-2344 (ISOFORM 1).
RA Roux A.-F.;
RT "Cloning of a mouse homolog of the Drosophila pecanex gene.";
RL Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1658-2344 (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, and Heart;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9QYC1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9QYC1-2; Sequence=VSP_022167;
CC -!- SIMILARITY: Belongs to the pecanex family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF21809.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AC124484; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC124595; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK129221; BAC98031.3; -; mRNA.
DR EMBL; AF096286; AAF21809.1; ALT_INIT; mRNA.
DR EMBL; AK014387; BAB29314.1; -; mRNA.
DR CCDS; CCDS26025.1; -. [Q9QYC1-1]
DR RefSeq; NP_061284.2; NM_018814.3. [Q9QYC1-1]
DR AlphaFoldDB; Q9QYC1; -.
DR SMR; Q9QYC1; -.
DR STRING; 10090.ENSMUSP00000021567; -.
DR GlyGen; Q9QYC1; 9 sites.
DR iPTMnet; Q9QYC1; -.
DR PhosphoSitePlus; Q9QYC1; -.
DR MaxQB; Q9QYC1; -.
DR PaxDb; Q9QYC1; -.
DR PeptideAtlas; Q9QYC1; -.
DR PRIDE; Q9QYC1; -.
DR ProteomicsDB; 287978; -. [Q9QYC1-1]
DR Antibodypedia; 25184; 72 antibodies from 18 providers.
DR DNASU; 54604; -.
DR Ensembl; ENSMUST00000021567; ENSMUSP00000021567; ENSMUSG00000021140. [Q9QYC1-1]
DR GeneID; 54604; -.
DR KEGG; mmu:54604; -.
DR UCSC; uc007ocq.1; mouse. [Q9QYC1-1]
DR CTD; 54604; -.
DR MGI; MGI:1891924; Pcnx.
DR VEuPathDB; HostDB:ENSMUSG00000021140; -.
DR eggNOG; KOG3604; Eukaryota.
DR GeneTree; ENSGT00940000157417; -.
DR HOGENOM; CLU_000602_0_1_1; -.
DR InParanoid; Q9QYC1; -.
DR OMA; ISTWHRL; -.
DR OrthoDB; 63639at2759; -.
DR PhylomeDB; Q9QYC1; -.
DR TreeFam; TF313570; -.
DR BioGRID-ORCS; 54604; 3 hits in 73 CRISPR screens.
DR ChiTaRS; Pcnx; mouse.
DR PRO; PR:Q9QYC1; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q9QYC1; protein.
DR Bgee; ENSMUSG00000021140; Expressed in cortical plate and 248 other tissues.
DR ExpressionAtlas; Q9QYC1; baseline and differential.
DR Genevisible; Q9QYC1; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR039797; Pecanex.
DR InterPro; IPR007735; Pecanex_C.
DR PANTHER; PTHR12372; PTHR12372; 1.
DR Pfam; PF05041; Pecanex_C; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Glycoprotein; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..2344
FT /note="Pecanex-like protein 1"
FT /id="PRO_0000215794"
FT TRANSMEM 33..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1010..1030
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1035..1055
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1069..1089
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1119..1139
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1163..1183
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1196..1216
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1269..1289
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1297..1317
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 101..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 271..290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 306..692
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 749..837
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2051..2123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..163
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 325..359
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 368..413
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 414..456
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 480..497
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 511..549
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 569..583
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 610..639
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 645..677
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 678..692
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 800..837
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 1094
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1158
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1582
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1723
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1985
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2075
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2231
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2237
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2263
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 854..945
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14621295"
FT /id="VSP_022167"
FT CONFLICT 930..934
FT /note="Missing (in Ref. 3; AAF21809)"
FT /evidence="ECO:0000305"
FT CONFLICT 1220
FT /note="S -> N (in Ref. 3; AAF21809)"
FT /evidence="ECO:0000305"
FT CONFLICT 1457
FT /note="L -> R (in Ref. 3; AAF21809)"
FT /evidence="ECO:0000305"
FT CONFLICT 1806
FT /note="A -> T (in Ref. 4; BAB29314)"
FT /evidence="ECO:0000305"
FT CONFLICT 1874
FT /note="E -> K (in Ref. 4; BAB29314)"
FT /evidence="ECO:0000305"
FT CONFLICT 1899
FT /note="D -> Y (in Ref. 4; BAB29314)"
FT /evidence="ECO:0000305"
FT CONFLICT 2318
FT /note="K -> N (in Ref. 3; AAF21809)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 2344 AA; 258147 MW; FF3E3C60D57488CB CRC64;
MGSQTLQILR QGVWAALSGG WYYDPHQATF VNALHLYLWL FLLGLPFTLY MALPSSMIIV
AVYCPVVAAV FIILKMVNYR LHRALDAGEI VDRSAKEFTD QRAKAEQGNC STRRKDSNGP
SDPGGGIEMS EFIREATPPV GCSSRNSYAG LDPSNQIGSG SSRLGTAATI KGDTDTAKTS
DDISLSLGQS SSLCKEGSEE QDLATDRKLF RLVSNDSFIS IQPSLSSCGQ DLPRDFSDKV
SLPSHSQHHR VDQSLCSACD TEVASLVPLH SHSYRKEHRP RGVPRTSSSA VAFPDASLSG
LPLYQQQQRR GLDPVTELDS SKPHSGTRES SAGKSCPPAQ SQPAADRRKS SSQPPTKCGK
SRALNAEKSV DSLRSLSTRS SGSTESYCSG TDRDTNSTLS SYKSEQTSST HIESILSEHE
ESPKVGDKSA RKRECGADSV EERSHRADDR RTSSDKTAPE GNTPAGPPEA PDAQASEEMA
DQAAPSSSAS EDANKNPHAN EFTVPGDRPP EQSAESKEEQ SEKPSLATDS RVCKDDGGKQ
KEGDVRPKSS SLIHRTTSAH KPGRRRTGKK RASSFDSSRH RDYVSFRGVS GTKPHSAVFG
HDEDSSDQSD LSRAPSIHSA HQFSSDSSSS ATSHSCQSPE GKYGALKTKH GHRDRGTDSD
HTHRAHPGPE GTTKKRASRR TSSTSSAKTR ARVLSLDSGT VACLNDSNRL LAPDSMKPLT
TSKSDLEAKE GEVLDELSLL GRASQLETVT RSRNSLPSQV AFPEGEEQDA ATGAAQASEE
AVAFRRERST FRRQAVRRRH NAGSNPTPPT LLIGSPLSLQ DGQQGQQSTA QVKVQSRPPS
QAAVLSASAS LLVRKGSVHL EASHDHASAV GGSSLHDELG KFSSTLYETG GCDMSLVNFE
PAARRASNIC DTDSHVSSST SVRFYPHDML SLPQIRLNRL LTIDTDLLEQ QDIDLSPDLA
ATYGPTEEAA QKVKHYYRFW VLPQLWIGIN FDRLTLLALF DRNREILENI LAVVLAILVA
FLGSILLIQG FFRDIWVFQF CLVIASCQYS LLKSVQPDSS SPRHGHNRII AYSRPVYFCL
CCGLIWLLDY GSRNLTTSKF KLYGVTFTNP LVLLSARDLV IVFTLCFPIV FFIGLLPQVN
TFVMYLCEQL DIHIFGGNAT TSLLAALYSF LCSIVAVALL YGLCYGALRD SWDGQHVPVL
FSVFCGLLVA VSYHLSRQSS DPSVLFSLMQ SKIFPKADEK NPEDPLSEVK DPLPEKLSNS
VSERLQSDLV VCVIIGVLYF AIHVSTVFTA LQPALKYVLY ALVGVVGLVT HYVLPQVRKQ
LPWHCFSRPL LRTAEHSQYE VRNAATMMWF EKLHVWLLFV EKNIIYPLIV LNELSSSAET
IASPKKLDTE LGALMITIAG LKLLRSSFSS PTYQYITVIF TVLFFKFDYE AFSETMLLDL
FFMSILFSKL WELLYKLQFV YTYVAPWQIT WGSAFHAFAQ PFAVPHSAML FVQAIVSAFF
STPLNPFLGS AIFITSYVRP VKFWERDYNT KRVDHSNTRL ASQLDRNPGS DDNNLNSIFY
EHLTRSLQHS LCGDLLLGRW GNYSTGDCFI LASDYLNALV HLIEIGNGLV TFQLRGLEFR
GTYCQQREVE AITEGVEEDE GFCCCEPGHV PHVLSFNAAF GQRWLAWEVV VTKYILEGYS
ITDNSAASML QVFDLRRVLT TYYVKGIIYY VTTSSKLEEW LANETMQEGL RLCADRNYVD
VDPTFNPNID EDYDHRLAGI SRESFCVIYL SWIEYCSSRR AKPLDVDKDS SLVTLCYGLC
VLGRRALGTA SHHMSSNLES FLYGLHALFK GDFRISSVRD EWIFADMELL RKVVVPGIRM
SIKLHQDHFT SPDEYDDPTV LYEAIVSHEK NLVIAHEGDP AWRSAVLANS PSLLALRHVM
DDGTNEYKII MLNRRYLSFR VIKVNKECVR GLWAGQQQEL VFLRNRNPER GSIQNAKQAL
RNMINSSCDQ PIGYPIFVSP LTTSYSDSHD QLKEILGGPI SLGNIRNFIV STWHRLRKGC
GAGCNSGGNI EDSDTGGGTS CPGNSAVTAS DPHNNVSQGS TGHPGQGAGS GLHPPTTSYP
PTLGTSHSAH SVQSSLVRQS PARASMASQS SYCYSSRHSS LRMSTTGFVP CRRSSTSQIS
LRNLPSSIQS RLSMVNQMEA ASQGGMGCVQ HGLPSSSSSS QSIPACKHHT LVAFLGAEGG
QGSATEAQPG NTSSPANISH ARKGEVIYRV QIVDLSQILE GINVSKRKEL HWPDEGIRLK
AGRNSWKDWS PQEGMEGHVV HRWVPCSRDP STRSHIDKTV LLVQIDDKYV TIIETGVLEL
GAEV
