PCX1_RAT
ID PCX1_RAT Reviewed; 2343 AA.
AC E9PSU6;
DT 31-JAN-2018, integrated into UniProtKB/Swiss-Prot.
DT 05-APR-2011, sequence version 1.
DT 03-AUG-2022, entry version 62.
DE RecName: Full=Pecanex-like protein 1;
DE AltName: Full=Pecanex 1 {ECO:0000303|PubMed:15777640};
DE AltName: Full=Pecanex homolog protein 1;
GN Name=Pcnx1 {ECO:0000312|RGD:1306115}; Synonyms=Pcnx;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND TISSUE SPECIFICITY.
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2]
RP TISSUE SPECIFICITY.
RX PubMed=15777640; DOI=10.1016/j.bbaexp.2005.01.010;
RA Geisinger A., Alsheimer M., Baier A., Benavente R., Wettstein R.;
RT "The mammalian gene pecanex 1 is differentially expressed during
RT spermatogenesis.";
RL Biochim. Biophys. Acta 1728:34-43(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Specifically expressed in the germ line and not in
CC the somatic cells of the testis, reaching its peak at the pachytene
CC stage of the meiotic prophase. Detected in pachytene spermatocytes and
CC round spermatids (at protein level). {ECO:0000269|PubMed:15777640}.
CC -!- SIMILARITY: Belongs to the pecanex family. {ECO:0000305}.
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DR EMBL; AABR07065047; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001163818.1; NM_001170347.1.
DR AlphaFoldDB; E9PSU6; -.
DR STRING; 10116.ENSRNOP00000010022; -.
DR PaxDb; E9PSU6; -.
DR PRIDE; E9PSU6; -.
DR Ensembl; ENSRNOT00000010022; ENSRNOP00000010022; ENSRNOG00000007459.
DR GeneID; 314288; -.
DR KEGG; rno:314288; -.
DR CTD; 22990; -.
DR RGD; 1306115; Pcnx1.
DR eggNOG; KOG3604; Eukaryota.
DR GeneTree; ENSGT00940000157417; -.
DR HOGENOM; CLU_000602_0_1_1; -.
DR InParanoid; E9PSU6; -.
DR OMA; ISTWHRL; -.
DR OrthoDB; 63639at2759; -.
DR PhylomeDB; E9PSU6; -.
DR TreeFam; TF313570; -.
DR PRO; PR:E9PSU6; -.
DR Proteomes; UP000002494; Chromosome 6.
DR Bgee; ENSRNOG00000007459; Expressed in skeletal muscle tissue and 19 other tissues.
DR Genevisible; E9PSU6; RN.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR039797; Pecanex.
DR InterPro; IPR007735; Pecanex_C.
DR PANTHER; PTHR12372; PTHR12372; 1.
DR Pfam; PF05041; Pecanex_C; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..2343
FT /note="Pecanex-like protein 1"
FT /id="PRO_0000442941"
FT TRANSMEM 33..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 978..998
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1009..1029
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1034..1054
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1068..1088
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1118..1138
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1162..1182
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1195..1215
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1268..1288
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1296..1316
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1406..1426
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1434..1454
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1458..1478
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1493..1513
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 98..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 271..290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 306..691
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 749..826
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2050..2120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..118
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..163
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 325..359
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 368..413
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 414..455
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 479..496
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 510..548
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 568..582
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 609..641
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 644..676
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2343 AA; 257943 MW; DB70755A9F38733D CRC64;
MGSQTLQILR QGVWAALSGG WYYDPHQATF VNALHLYLWL FLLGLPFTLY MALPSSMIIV
AVYCPVVAAV FIVLKMVNYR LHRALDAGEV VDRSANEFTD QRAKAEQGNC STRRKDSNGP
SDPGGGIEMS EFIREATPPV GCSSRNSYAG LDPSNQIGSG SSRLGTAATI KGDTDTAKTS
DDISLSLGQS SSLCKEGSEE QDLATDRKLF RLVSNDSFVS IQPSLSSCGQ DLPRDFSDKV
SLPSHSQHHR VDQSLCSACD TEVASLVPLH SHSYRKEHRP RGVPRTSSSA VAFPDASLSG
LPLYQQQQRR GLDPVTELDS SKPHSGTRES LVGQSCPLAQ SQPAADRRKS YSQPPTKCGK
SRALNAEKSV DSLRSLSTRS SGSTESYCSG TDRDTNSTLS SYKSEQTSST HIESILSEHD
ESPKVGDKSA RKEGCAESAE ERCHGATDRR TSSDKTALEG STPAGPPEAP DAQASEEKPD
QVAPSSSASE DANKNPHANE FTVPGDRPPE QSAESKEEQG EKPSLSTDSK VCKDDGGKQK
EGDVRPKSSS LIHRTTSAHK PGRRRTGKKR ASSFDSSRHR DYVSFRGVSG TKPHSAIFCH
DEDSSDQSDL SRAPSVHSAH HFSSDSSSSA TSHSCQSPEG KYSALKTKHG HKDRGTDSDH
THRAHPGPEG TAKKRASRRT SSTHSAKTRA RVLSLDSGTV ACLNDSNRLL APDSIKPLTT
SKSDLEAKEG EVLDELSLLG RASQLETVTR SRNSLPSQVA FPEGEEQDAA TGAAQASEEA
VAFRRERSTF RRQAVRRRHN AGSNPTPPTL LIGPPLSLQD GQQGQQSTAQ VKVQSRPPSQ
AAVLSASASL LVRKGSVHLD ASHDHASAVG GSSLHDELGK FSSTLYETGG CDMSLVNFEP
AARRASNICD TDSHVSSSTS VRFYPHDMLS LPQIRLNRLL TIDTDLLEQQ DIDLSPDLAA
TYGPTEEAAQ KVKHYYRFWI LPQLWIGINF DRLTLLALFD RNREILENIL AVVLAILVAF
LGSILLIQGF FRDIWVFQFC LVIASCQYSL LKSVQPDSSS PRHGHNRIIA YSRPVYFCLC
CGLIWLLDYG SRNLSTSKFK LYGITFTNPL VLLSARDLVI VFTLCFPIVF FIGLLPQVNT
FVMYLCEQLD IHIFGGNATT SLLAALYSFL CSVVAVALLY GLCYGALRDS WDGQHIPVLF
SVFCGLLVAV SYHLSRQSSD PSVLFSLIQS KIFPKTDEKN PEDPLSEVKD PLPEKLSNSV
SERLQSDLVV CVVIGVLYFA IHVSTVFTAL QPALKYVLYA LVGFVGLVTH YVLPQVRKQL
PWHCFSRPLL KTAEHNQYEV RNAATMMWFE KLHVWLLFVE KNVIYPLIVL NELSSSADTI
ASPKKLDTEL GALMITVAGL KLLRSSFSSP TYQYITVIFT VLFFKFDYEA FSETMLLDLF
FMSILFSKLW ELLYKLQFVY TYVAPWQITW GSAFHAFAQP FAVPHSAMLF VQAVVSALFS
TPLNPFLGSA IFITSYVRPV KFWERDYNTK RVDHSNTRLA SQLDRNPGSD DNNLNSIFYE
HLTRSLQHSL CGDLLLGRWG NYSTGDCFIL ASDYLNALVH LIETGNGLVT FQLRGLEFRG
TYCQQREVEA ITEGVEEDEG FCCCEPGHVP HVLSFNAAFG QRWLAWEVVV TKYILEGYSI
TDNSAASMLQ VFDLRRVLTT YYVKGIIYYV TTSSKLEEWL ANETMQEGLR LCADRNYVDV
DPTFNPNIDE DYDHRLAGIS RESFCVIYLN WIEYCSSRRA KPLDVDKDSS LVTLCYGLCV
LGRRALGTAS HHMSSNLESF LYGLHALFKG DFRISSVRDE WIFADMELLR KVVVPGIRMS
IKLHQDHFTS PDEYDDPTVL YEAIVSHEKN LVIAHEGDPA WRSAVLANSP SLLALRHVMD
DGTNEYKIIM LNRRYLSFRV IKVNKECVRG LWAGQQQELV FLRNRNPERG SIQNAKQALR
NMINSSCDQP IGYPIFVSPL TTSYSDSHDQ LKEILGGPIS LGNIRDFIVS TWHRLRKGCG
AGCNSGGNIE DSDTGGGTSC PANSATTASD PHNSVPQGST GHPGQGAGSG LHPPTTSYPP
TLGTSHSAHS VQSSLVRQSP ARASMASQSS YCYGSRHSSL RMSTTGFVPC RRSSTSQISL
RNLPSSIQSR LSMVNQMEAA SQGGMGCVQH GLPSSSSSSQ SIPACKHHTL VAFLGAEGSQ
SGATEAQPGN TSSPATISHA RKGEVVYRVQ IVDLSQILEG INVSKRKELQ WPDEGIRLKA
GRNSWKDWSP QEGMEGHVVH RWVPCSRDPS TRSHIDKTVL LVQIDDKYVT VIETGVLELG
AEV
