PCX2_MOUSE
ID PCX2_MOUSE Reviewed; 2122 AA.
AC Q5DU28; A2RT20; Q8BRN0; Q8C2V1; Q8CDD2;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-MAY-2008, sequence version 2.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Pecanex-like protein 2;
DE AltName: Full=Pecanex homolog protein 2 {ECO:0000312|MGI:MGI:2445010};
GN Name=Pcnx2 {ECO:0000312|MGI:MGI:2445010}; Synonyms=Kiaa0435, Pcnxl2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4), AND NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 136-2122 (ISOFORM 3).
RC STRAIN=C57BL/6J; TISSUE=Brain cortex, Ovary, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 182-2122 (ISOFORM 3).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 735-2122 (ISOFORM 1).
RC TISSUE=Brain;
RA Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O.,
RA Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene. The
RT complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by
RT screening of terminal sequences of cDNA clones randomly sampled from size-
RT fractionated libraries.";
RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May play a role in tumorigenesis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q5DU28-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5DU28-2; Sequence=VSP_033613, VSP_033616;
CC Name=3;
CC IsoId=Q5DU28-3; Sequence=VSP_033614, VSP_033615;
CC Name=4;
CC IsoId=Q5DU28-4; Sequence=VSP_033612;
CC -!- SIMILARITY: Belongs to the pecanex family. {ECO:0000305}.
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DR EMBL; AK030215; BAC26849.1; -; mRNA.
DR EMBL; AK043903; BAC31698.1; -; mRNA.
DR EMBL; AK087907; BAC40038.1; -; mRNA.
DR EMBL; AC105066; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC151909; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC132334; AAI32335.2; -; mRNA.
DR EMBL; AK220342; BAD90408.1; -; mRNA.
DR CCDS; CCDS52708.1; -. [Q5DU28-1]
DR RefSeq; NP_780770.2; NM_175561.4. [Q5DU28-1]
DR AlphaFoldDB; Q5DU28; -.
DR STRING; 10090.ENSMUSP00000042294; -.
DR GlyGen; Q5DU28; 6 sites.
DR iPTMnet; Q5DU28; -.
DR PhosphoSitePlus; Q5DU28; -.
DR SwissPalm; Q5DU28; -.
DR MaxQB; Q5DU28; -.
DR PaxDb; Q5DU28; -.
DR PRIDE; Q5DU28; -.
DR ProteomicsDB; 288004; -. [Q5DU28-1]
DR ProteomicsDB; 288005; -. [Q5DU28-2]
DR ProteomicsDB; 288006; -. [Q5DU28-3]
DR ProteomicsDB; 288007; -. [Q5DU28-4]
DR Antibodypedia; 11747; 53 antibodies from 19 providers.
DR DNASU; 270109; -.
DR Ensembl; ENSMUST00000047239; ENSMUSP00000042294; ENSMUSG00000060212. [Q5DU28-1]
DR Ensembl; ENSMUST00000131127; ENSMUSP00000119965; ENSMUSG00000060212. [Q5DU28-3]
DR GeneID; 270109; -.
DR KEGG; mmu:270109; -.
DR UCSC; uc009nyl.1; mouse. [Q5DU28-4]
DR UCSC; uc009nym.1; mouse. [Q5DU28-2]
DR UCSC; uc009nyn.2; mouse. [Q5DU28-1]
DR UCSC; uc009nyo.1; mouse. [Q5DU28-3]
DR CTD; 80003; -.
DR MGI; MGI:2445010; Pcnx2.
DR VEuPathDB; HostDB:ENSMUSG00000060212; -.
DR eggNOG; KOG3604; Eukaryota.
DR GeneTree; ENSGT00940000157374; -.
DR HOGENOM; CLU_000602_3_0_1; -.
DR InParanoid; Q5DU28; -.
DR OMA; NHKIPSN; -.
DR OrthoDB; 63639at2759; -.
DR PhylomeDB; Q5DU28; -.
DR TreeFam; TF313570; -.
DR BioGRID-ORCS; 270109; 5 hits in 72 CRISPR screens.
DR ChiTaRS; Pcnx2; mouse.
DR PRO; PR:Q5DU28; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q5DU28; protein.
DR Bgee; ENSMUSG00000060212; Expressed in primary motor cortex and 89 other tissues.
DR Genevisible; Q5DU28; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR039797; Pecanex.
DR InterPro; IPR007735; Pecanex_C.
DR PANTHER; PTHR12372; PTHR12372; 1.
DR Pfam; PF05041; Pecanex_C; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..2122
FT /note="Pecanex-like protein 2"
FT /id="PRO_0000333966"
FT TRANSMEM 36..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..82
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 825..845
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 849..869
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 882..902
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 933..953
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 976..998
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1010..1030
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1080..1100
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1105..1125
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1174..1194
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1218..1238
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1245..1265
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1270..1290
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1305..1325
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 92..164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 180..250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 392..556
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 575..634
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1858..1943
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1955..1991
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2097..2122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 139..161
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 181..203
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 392..406
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 468..482
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 598..619
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1887..1910
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1919..1943
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1955..1989
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2108..2122
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 288
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 556
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1393
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1534
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1802
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2039
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..1443
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_033612"
FT VAR_SEQ 1..1067
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_033613"
FT VAR_SEQ 1073..1121
FT /note="KDVLRSDLVICSAAAVLSFAVSASTVFLSLRPFLSIVLFALAGTVGLIT ->
FT VRPQHGKTACHRGPCLSAGMKLPGYSELAGSGKAGGGPWVQSRLISRDT (in
FT isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_033614"
FT VAR_SEQ 1122..2122
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_033615"
FT VAR_SEQ 1452
FT /note="G -> GC (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_033616"
SQ SEQUENCE 2122 AA; 234128 MW; 49D31B483000EA97 CRC64;
MASQVLQLLR QGVWAALTGG WYHDPEHSKF TNSCHLYLWL FLLLLPLALH LAFPPNVLTA
LFYCGSVTIF FAVIKLISYR LHLMFDKGEA IQHRSPRKRS KRKPEGEASS QHTARHKNPS
NNRQIHSTKK EEPRGSLTTP PLCCSSRGQS VHSQHSSGPL ELPAQETVED LKGVVLSEDQ
PEALASSTSP GMKSESLPAS QGRTPEPTPR PACPLKPVTT ELFTARKGKE SGGTAQRPAR
HRSESGLVNP GALKKLPQLS LSQYDLLETD ISFQPWGSEH SVLLPQPNCT QGATRAQPQN
RSPQDSLSSS CCQCNTVLAK PTEEELTRTS GQVELPLNQE VVDSDGEVAV TLIDTSQPGE
PLSLHEPIKI VITMSSTQNS ISDLESSLHL RVTSSDRTSV RSSAESAGSG GAGPADPEQV
RIPLITLELT EDGGGRGVSC SEGNGGERTP ERMEVMSPDR CSGSGPGDGS PTPGSTLATL
TPRVDPESEG SKEGQANLDP ASCKSSHEKR HARVLSVDSG TDVFLSRSTK EVVSDGEKPI
PTSKSDLEAK EGQIPNESNF LEFVSLLESI STSKVVAPDS PAEQKGASQG PEGHASPGTK
EEAVENEKPN GRDPKPGKPD LPSQDPANGS PVFTQPAKSA ALFQGSRQRH IIYRVTSQQD
SSVLQVISGP ETSVQEEMSL DAMHVFIDEH GEVRSCYLKS GNQKEGSSQH PPLNPDCVSH
ARGILLSSSS STATGSPDPS SGDPAVSALQ QQLLLMVARR TQSETPRHVS QDLEDSSRSS
AQGKFNREQF YKFIVFPGKW IKVWYDRLTL LALLDRTEDV KENMVAVLLS VLVSLLGFLT
LNRGFCRDLW VLLFCLVMAS CQYSLLKSVQ PDPASPIHGH NQIIAYSRPI YFCMLCSLIL
LLDAGAKAKH PPSYVVYGLK LFTPETLQAV RDHLIVFLCC FPAISLLGLF PQINTFCTYL
LEQIDMLLFG GSAVSGITSA VYSVGRSVLA AALLHAFCFS AVKEPWSTQH IPALFSAFCG
LLVALSYHLS RQSSDPSVLL SFIQCKLLPK CLHQNLEESA TDPLPQRMKD SVKDVLRSDL
VICSAAAVLS FAVSASTVFL SLRPFLSIVL FALAGTVGLI THHLLPQLRK HHPWMWISHP
VLRSKEYQQR EARDIAHLMW FERLYVWLQC FEKYLLYPAI VLNALTLDAF SISNYRRLGT
HWDIFLMITA GMKLLRTSFC NPVHQFANLG FTVIFFHFDY KDISESFLLD FFMVSIVFTK
LGDLLQKLQF VLAYVAPWQM AWGSSFHVFA QLFAIPHSAM LFFQTFATSI FSTPLSPFLG
SVIFITSYVR PVKFWERSYN TRRMDNSNTR LAVQMERDPG SDDNNLNSIF YEHLTRTLQE
SLCGDLVLGR WGNYSSGDCF ILASDDLNAF VHLIEIGNGL VTFQLRGLEF RGTYCQQREV
EAIMEGDEDD RGCCCCKPGH LPHLLSCNAA FHLRWLTWEI TRTQYILEGY SIIDNNAATM
LQVYDLRRVL IRYYVKSIIY YMVTSPKLVS WVKNESLLKS LQPFAKWHHI ERDLAMFNIN
IDDDYVPCLQ GITRASYCNV FLEWIQYCAG KRQELSKTLE HVDSDEDSAL VTLAFALCIL
GRRALGTAAH NMAMSLDSFL YGLHALFKGD FRVTARDEWV FADMDLLHKV VVPAIRMSLK
LHQDQFTCPD EYEDPAVLYE AIRSFAKKVV ICHEGDPAWR GAMLSNKEEL LTLRHVVDEG
ADEYKVIMLH RGFLSFKVIK VNKECVRGLW AGQQQELIFL RNRNPERGSI QNNKQVLRNL
INSSCDQPLG YPMYVSPLTT SYLGTHKQLQ SVWGGPVTLN RVRTWFQTRW LRMRKDCSVG
QRSGGGNIED GEGGAVPSAG GGSAPNGESR DGSTEQPRKG GTQQWSSPRG EAQRAGRRKG
RSQSVQAHSA ISQRPPTLSS SGPILESHQA FLQTSTSVHE LAQRPSGSRL SLHTSAASLH
SQPPPVTTTG HLSVRERAEA LIRSSLGSST SSTLSFLFGK RSFSSALVIS GLSAAEGGNT
SDTQSSSSVN IVMGPSARAA GHAARHFSEP CEPTDSPEQG QLQDGRLAEA MEENLGVLCR
RASQEDMGLD DTASQQSTSD EQ
