ASPM_CANLF
ID ASPM_CANLF Reviewed; 3469 AA.
AC P62286;
DT 05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 2.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Abnormal spindle-like microcephaly-associated protein homolog;
GN Name=ASPM;
OS Canis lupus familiaris (Dog) (Canis familiaris).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX NCBI_TaxID=9615;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Boxer;
RX PubMed=16341006; DOI=10.1038/nature04338;
RA Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B.,
RA Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C., Mauceli E.,
RA Xie X., Breen M., Wayne R.K., Ostrander E.A., Ponting C.P., Galibert F.,
RA Smith D.R., deJong P.J., Kirkness E.F., Alvarez P., Biagi T., Brockman W.,
RA Butler J., Chin C.-W., Cook A., Cuff J., Daly M.J., DeCaprio D., Gnerre S.,
RA Grabherr M., Kellis M., Kleber M., Bardeleben C., Goodstadt L., Heger A.,
RA Hitte C., Kim L., Koepfli K.-P., Parker H.G., Pollinger J.P.,
RA Searle S.M.J., Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A.,
RA Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P.,
RA Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L., Bachantsang P.,
RA Barry A., Bayul T., Benamara M., Berlin A., Bessette D., Blitshteyn B.,
RA Bloom T., Blye J., Boguslavskiy L., Bonnet C., Boukhgalter B., Brown A.,
RA Cahill P., Calixte N., Camarata J., Cheshatsang Y., Chu J., Citroen M.,
RA Collymore A., Cooke P., Dawoe T., Daza R., Decktor K., DeGray S.,
RA Dhargay N., Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L.,
RA Duffey N., Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S.,
RA Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K., Foley C.,
RA Franke A., Friedrich D., Gage D., Garber M., Gearin G., Giannoukos G.,
RA Goode T., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N.,
RA Hagopian D., Hagos B., Hall J., Healy C., Hegarty R., Honan T., Horn A.,
RA Houde N., Hughes L., Hunnicutt L., Husby M., Jester B., Jones C., Kamat A.,
RA Kanga B., Kells C., Khazanovich D., Kieu A.C., Kisner P., Kumar M.,
RA Lance K., Landers T., Lara M., Lee W., Leger J.-P., Lennon N., Leuper L.,
RA LeVine S., Liu J., Liu X., Lokyitsang Y., Lokyitsang T., Lui A.,
RA Macdonald J., Major J., Marabella R., Maru K., Matthews C., McDonough S.,
RA Mehta T., Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T.,
RA Miller K., Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A.,
RA Naylor J., Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N.,
RA Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K., Osman S.,
RA Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F., Priest M.,
RA Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C., Rege F.,
RA Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S., Sharpe T.,
RA Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J., Smith C.,
RA Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S., Stone C.,
RA Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S., Thoulutsang D.,
RA Thoulutsang Y., Topham K., Topping I., Tsamla T., Vassiliev H.,
RA Venkataraman V., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA Wilson A., Yadav S., Yang S., Yang X., Young G., Yu Q., Zainoun J.,
RA Zembek L., Zimmer A., Lander E.S.;
RT "Genome sequence, comparative analysis and haplotype structure of the
RT domestic dog.";
RL Nature 438:803-819(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-3452.
RX PubMed=14722158; DOI=10.1093/hmg/ddh055;
RA Evans P.D., Anderson J.R., Vallender E.J., Gilbert S.L., Malcom C.M.,
RA Dorus S., Lahn B.T.;
RT "Adaptive evolution of ASPM, a major determinant of cerebral cortical size
RT in humans.";
RL Hum. Mol. Genet. 13:489-494(2004).
CC -!- FUNCTION: Probable role in mitotic spindle regulation and coordination
CC of mitotic processes. May have a preferential role in regulating
CC neurogenesis (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton,
CC spindle {ECO:0000250}. Nucleus {ECO:0000250}. Note=The nuclear-
CC cytoplasmic distribution could be regulated by the availability of
CC calmodulin. Localizes to spindle poles during mitosis (By similarity).
CC {ECO:0000250}.
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DR EMBL; AAEX02025887; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AY485421; AAR98742.1; -; mRNA.
DR RefSeq; NP_001184005.1; NM_001197076.1.
DR STRING; 9612.ENSCAFP00000016776; -.
DR PaxDb; P62286; -.
DR PRIDE; P62286; -.
DR GeneID; 480009; -.
DR KEGG; cfa:480009; -.
DR CTD; 259266; -.
DR eggNOG; KOG0165; Eukaryota.
DR HOGENOM; CLU_000237_0_0_1; -.
DR InParanoid; P62286; -.
DR OMA; CCCCYIF; -.
DR OrthoDB; 482623at2759; -.
DR TreeFam; TF351180; -.
DR Proteomes; UP000002254; Chromosome 7.
DR Bgee; ENSCAFG00000011403; Expressed in keratinocyte and 30 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007051; P:spindle organization; IEA:InterPro.
DR Gene3D; 1.10.418.10; -; 2.
DR Gene3D; 1.25.10.10; -; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR031549; ASH.
DR InterPro; IPR029955; ASPM.
DR InterPro; IPR001715; CH-domain.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR22590:SF4; PTHR22590:SF4; 5.
DR Pfam; PF15780; ASH; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00612; IQ; 41.
DR SMART; SM00033; CH; 2.
DR SMART; SM00015; IQ; 65.
DR SUPFAM; SSF47576; SSF47576; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR SUPFAM; SSF52540; SSF52540; 15.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50096; IQ; 38.
PE 2: Evidence at transcript level;
KW Calmodulin-binding; Cell cycle; Cell division; Coiled coil; Cytoplasm;
KW Cytoskeleton; Mitosis; Nucleus; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..3469
FT /note="Abnormal spindle-like microcephaly-associated
FT protein homolog"
FT /id="PRO_0000191328"
FT DOMAIN 913..1049
FT /note="Calponin-homology (CH) 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT DOMAIN 1102..1253
FT /note="Calponin-homology (CH) 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT DOMAIN 1258..1287
FT /note="IQ 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1339..1370
FT /note="IQ 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1385..1414
FT /note="IQ 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1529..1560
FT /note="IQ 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1574..1605
FT /note="IQ 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1624..1653
FT /note="IQ 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1647..1676
FT /note="IQ 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1720..1749
FT /note="IQ 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1743..1774
FT /note="IQ 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1793..1822
FT /note="IQ 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1816..1845
FT /note="IQ 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1866..1895
FT /note="IQ 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1889..1920
FT /note="IQ 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1939..1970
FT /note="IQ 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1962..1993
FT /note="IQ 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2012..2041
FT /note="IQ 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2035..2066
FT /note="IQ 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2085..2116
FT /note="IQ 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2108..2139
FT /note="IQ 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2158..2189
FT /note="IQ 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2181..2210
FT /note="IQ 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2231..2262
FT /note="IQ 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2304..2333
FT /note="IQ 23"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2327..2358
FT /note="IQ 24"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2377..2408
FT /note="IQ 25"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2400..2431
FT /note="IQ 26"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2450..2481
FT /note="IQ 27"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2523..2554
FT /note="IQ 28"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2681..2712
FT /note="IQ 29"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2731..2762
FT /note="IQ 30"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2851..2882
FT /note="IQ 31"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2901..2930
FT /note="IQ 32"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2924..2955
FT /note="IQ 33"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2946..2977
FT /note="IQ 34"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 3021..3050
FT /note="IQ 35"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 3071..3102
FT /note="IQ 36"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 3173..3202
FT /note="IQ 37"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 3196..3227
FT /note="IQ 38"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1050..1069
FT /evidence="ECO:0000255"
FT MOD_RES 273
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 276
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 361
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 386
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 420
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 599
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 1095
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT CONFLICT 1687
FT /note="R -> Q (in Ref. 2; AAR98742)"
FT /evidence="ECO:0000305"
FT CONFLICT 2175
FT /note="R -> G (in Ref. 2; AAR98742)"
FT /evidence="ECO:0000305"
FT CONFLICT 2182
FT /note="Q -> E (in Ref. 2; AAR98742)"
FT /evidence="ECO:0000305"
FT CONFLICT 2237
FT /note="C -> R (in Ref. 2; AAR98742)"
FT /evidence="ECO:0000305"
FT CONFLICT 2522
FT /note="P -> R (in Ref. 2; AAR98742)"
FT /evidence="ECO:0000305"
FT CONFLICT 2578
FT /note="E -> K (in Ref. 2; AAR98742)"
FT /evidence="ECO:0000305"
FT CONFLICT 2588
FT /note="L -> V (in Ref. 2; AAR98742)"
FT /evidence="ECO:0000305"
FT CONFLICT 2727
FT /note="K -> N (in Ref. 2; AAR98742)"
FT /evidence="ECO:0000305"
FT CONFLICT 3205
FT /note="S -> A (in Ref. 2; AAR98742)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 3469 AA; 407600 MW; 633CA3CE3A949BD6 CRC64;
MATRRAGRSW EVSPSGPRPA AGEAAAASPP VLSLSHFCRS PFLCFGDVRL GGSRTLPLLL
HNPNDEAARV EVCRAPAAQQ GFSVSPRRFQ LQPKEKIVIS VNWTPLKEGR VRETVTFLVN
DVLKHQAILL GNAEEQKKKK RSLWGTIKKK KMSASSNNKR ISSAQNVNKT FCVSQKADRV
RNPLQACENL DVNEGCSPTE NNSLILEENK IPISPISPIF KECNGETSLP LSVRRSTTYI
SLHARENGDL LKVEDASILE DFSFSEKVVN ETSFNSTNNI NDQTEENCKL ILTPACSSTL
NITQSQGNFL SPDSFVKNSR AANNELEVVT CLSSNILMKD NSMPLHLESK SVHENYRKIL
SPDSFINDNY GLNQDLESEP INPILSPNQF VKDNMAYTCI YQQTCKLSLS SNKNSQFSQS
QDPRTNGILP CIPECQSSKS PKATFEEHRA LEMKSDCYSF TKNQPKFSAM QDISSCSQDK
LTRRPILSAT ITKRKSNFTR ENQKETNKPK AKRCLNSVAG EFEKVTDNIK EKDGFQSCLP
VIDPVFSKPK SYKIVVTPPS KTTLIARKRR SEGDREDANV RITATGHSEI QEIKRIHFSP
VESKTSVLKK TKKMTTPISK HFNREKLNLK KKTDSRIYRT PNSKTSKKTK PIVAVAQSTL
TFIKPLKTDI PRHPMPFAAK NMFYDERWKE KQEQGFTWWL NFILTPDDFT VKTNISEVNA
ATLLLGVESQ HKISVPRAPT KDEMSLRAYT ARCRLNRLRR AACRLFTSEK MVKAIKKLEI
EIEARRLIVR RDRHLWKDVG ERQKVLNWLL SYNPLWLRIG LETVFGELLS LEDNSDVTGL
AVFILNRLLW NPDIAAEYRH PTVPHLYRDG HEEALSKFTL KKLLLLVCFL DYAKISKLID
HDPCLFCKDA EFKTSKDILL AFSRDFLSGE GDLSRHLSLL GLPVNHVQTP FDEFDFAVTN
LAVDLQCGVR LVRIMELLTR DWNLSKKLRM PAISRLQKMH NVDIVLQILR SQGIQLNDEH
GNAILSKDIV DRHREKTLAL LWKIAFAFQV DISLNLDQLK EEIDFLKHTQ SMKKMSAQSC
HSDVIINKKK DNRNSGSFEQ YSESIKLLME WVNAVCAFYN KKVENFTVSF SDGRVLCYLI
HHYHPYYVPF DAICQRTTQT IECTQTGSVV LNSSSESDGS SLDLSLKAFD HENTSELYKE
LLENEKKNFQ LVRSAVRDLG GIPAMINHSD MSNTIPDEKV VITYLSFLCS RLLDLCKETR
AARLIQTTWR KYKLKTDMKR HQEQDKAARI IQSAIINFLT KRRLKKEISA ALAIQKYWRR
FLAQRKLLML KKEKLEKVQN ESASIIQRYW RRYSTRKQFL KLRYYSIILQ SRIRMIIAVT
SYKRYLWATV TIQRHWRASL RRKHDQQRYK MLKSSCLIIQ SMFRRWKRRK MQLQIKATRV
LQRAFREWHV RKRAKEEKSA IVIQSWYRMH KELRKYVQIR SCVVIIQTRF RCLQAQKLYK
RKKEAILTIQ KYYKAYLKGK MERTNYLQKR AAAIRLQTAF RRMKARNLYR QSRAACVLQS
YWRMRQDRFR FLNLKKITTK LQAQVRKHQQ LQKYRKIKKA ALVIQIHFRA YVSAKKVLAS
YQKTRSAVLV LQSAYRGMQA RKKFIHILTS IIKIQSCYRA YISRKRFLRL KNATVKLQSI
VKMRQTRKRY LHWRAASLFI QRWYRSAKLA ALKRHQYVQM RESCIKLQAF VRGHLVRKQI
RLQRQAAISL QSYFRMRKKR QYYLEIYKAT LVIQNYYRAY KAQVNQRKNF LQVKRAVTCL
QAAYRGYKVR QLIKQQSIAA LKIQTAFRGY RERKKYQYVL QSTIKIQRWY RTCRTVRDVR
TQFLKTRAAV ISLQCAFRGW KVRKQIRRER QAAVRIQSAF RMAKAQKQFK LLKTAALVIQ
QHLRAWTAGK RQRMEYIELR EAALRLQSTW KGKRVRRQVQ KQHKCAVIIQ SNYRMYVQQK
KWKIMKKAAR LIQMYYRAYS IGRKQRQLYL KTKAAAVVLQ SAYRSMKVRK KIKECNRAAV
TIQSTYRAYK TKKNYTNCRA SAIIIQRWYR GTKIANHQRK EYLNLKKTAV KIQAIYRGIR
VRRHNRHLHM AATVIQAMFK MHQAKMRYHK MRTAAVIIQV RYRAYREGKI QRAKYLTIMK
AITVLQASFR GTRVRQTLRK MQSAATLIQS YYRRHRQQAY FTKLKKVTRT IQQRYRAVKE
RNTQLQRYNK LRHSIICIQA GFRGMKARRH LKSMHLAATL IQRRFRTLRM RRRFLHLRKT
AIWIQRKYRA TVCAKHYFQH FVRVQKAVIK IQSSYRGWMV RKKMQEVHRA ATAIQAAFRM
HRANVKYQAL KHASVVIQQQ FRASRAAKLQ RQCYLQQRHS ALILQAAFRG MKARGHLKNM
HSSATLIQST FRSLVVRKRF ISLKRATVFV QRKYRATICA RHHLHQFLKL KKAVITIQSS
YRRLVAKKKL QEMHRAAVLI QATYRMHRTY VTFQTWKHAS ILIQQHYRTY RAAKLQRENS
VPQRRSALII QAVYKGMKAR QLLREKHRAA IIIQSTYRMY RQYLFYQKIQ WATKVIQEKY
RANKKKALQH SALRNAAAAC TEADFQDMIL RKPTQEQHQA ATIIQKHFKA SKVRKHYLHL
RANVIFVQRR YRALTAVRTQ AVVCTQSSYR SCKVQEDMQH RHLAATRIQS FYRMHRAKLD
YQAKKTAVAV IQNYFRSYIR VKVEREKFLA VQKSVRIIQA AFRGMKVRER LKSLSEVNMV
ASAKQSAFYS CRTEAQCAAV HGSALRTQKW HGASLVTCSQ EAEYPQREAL VATQRAFCEM
VTRKLETQKC AALRIQYFLQ MAVCRRRFVQ QKRAAVTLQQ YFRTWQTRRQ FLLYRKAAVV
LQNHHRAFLS TKHQRQVYLQ IRSSIIMIQA RTRGFIQKRR FQKIKDSTIK IQAVWRSYKA
RKYLHQVKAA CKIQAWYRYW KARKDYLAVL KAVKIIQGCF YTKLERRRFL NVRASTIIIQ
RKWRAILSGR IACEHFLMIK RHQAACLIQA NFRRYKGRQV FLRQKSAALT IQRYIRARKA
GKCQRIKYVE LKKSTVVLQA LVRGWLVRKR ILEQRTKIRL LHFTAAAYYH LSALKIQRAY
KRHMAMKNAN KQVNAVICIQ RWFRTRLQQK RFAQKYPSIL TSQHEVPECM SQQNRAASVI
QKAVRRFLLR KKQEKFNNAI SRIQSLWRGY SWRKKNDCTK IKAIRLSLQL VNREIREENK
LYKRTALALH YLLTYKHLSA ILEALKHLEV VTRLSPLCCE NMAQSGAVSK IFVLIRSCNR
SIPCMEVIRY AVQVLLNVAK YEKTTAAVSD VENCIDTLLD LLQMYREKPG DKVADKGGSI
FTKTCCLLAV LLKTTNRASS VRSKSKVVDR IYSLYKLTAR KHKMNTERTL YKQKMNSSIS
TPFIPETPVR TRIVSRLKPD WVLRRDNMEE ITNPLQAIQM VMDTLGIPY
