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ASPM_CANLF
ID   ASPM_CANLF              Reviewed;        3469 AA.
AC   P62286;
DT   05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2010, sequence version 2.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Abnormal spindle-like microcephaly-associated protein homolog;
GN   Name=ASPM;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Boxer;
RX   PubMed=16341006; DOI=10.1038/nature04338;
RA   Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B.,
RA   Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C., Mauceli E.,
RA   Xie X., Breen M., Wayne R.K., Ostrander E.A., Ponting C.P., Galibert F.,
RA   Smith D.R., deJong P.J., Kirkness E.F., Alvarez P., Biagi T., Brockman W.,
RA   Butler J., Chin C.-W., Cook A., Cuff J., Daly M.J., DeCaprio D., Gnerre S.,
RA   Grabherr M., Kellis M., Kleber M., Bardeleben C., Goodstadt L., Heger A.,
RA   Hitte C., Kim L., Koepfli K.-P., Parker H.G., Pollinger J.P.,
RA   Searle S.M.J., Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A.,
RA   Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P.,
RA   Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L., Bachantsang P.,
RA   Barry A., Bayul T., Benamara M., Berlin A., Bessette D., Blitshteyn B.,
RA   Bloom T., Blye J., Boguslavskiy L., Bonnet C., Boukhgalter B., Brown A.,
RA   Cahill P., Calixte N., Camarata J., Cheshatsang Y., Chu J., Citroen M.,
RA   Collymore A., Cooke P., Dawoe T., Daza R., Decktor K., DeGray S.,
RA   Dhargay N., Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L.,
RA   Duffey N., Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K., Foley C.,
RA   Franke A., Friedrich D., Gage D., Garber M., Gearin G., Giannoukos G.,
RA   Goode T., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N.,
RA   Hagopian D., Hagos B., Hall J., Healy C., Hegarty R., Honan T., Horn A.,
RA   Houde N., Hughes L., Hunnicutt L., Husby M., Jester B., Jones C., Kamat A.,
RA   Kanga B., Kells C., Khazanovich D., Kieu A.C., Kisner P., Kumar M.,
RA   Lance K., Landers T., Lara M., Lee W., Leger J.-P., Lennon N., Leuper L.,
RA   LeVine S., Liu J., Liu X., Lokyitsang Y., Lokyitsang T., Lui A.,
RA   Macdonald J., Major J., Marabella R., Maru K., Matthews C., McDonough S.,
RA   Mehta T., Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T.,
RA   Miller K., Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A.,
RA   Naylor J., Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N.,
RA   Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K., Osman S.,
RA   Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F., Priest M.,
RA   Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C., Rege F.,
RA   Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S., Sharpe T.,
RA   Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J., Smith C.,
RA   Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S., Stone C.,
RA   Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S., Thoulutsang D.,
RA   Thoulutsang Y., Topham K., Topping I., Tsamla T., Vassiliev H.,
RA   Venkataraman V., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Yang S., Yang X., Young G., Yu Q., Zainoun J.,
RA   Zembek L., Zimmer A., Lander E.S.;
RT   "Genome sequence, comparative analysis and haplotype structure of the
RT   domestic dog.";
RL   Nature 438:803-819(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-3452.
RX   PubMed=14722158; DOI=10.1093/hmg/ddh055;
RA   Evans P.D., Anderson J.R., Vallender E.J., Gilbert S.L., Malcom C.M.,
RA   Dorus S., Lahn B.T.;
RT   "Adaptive evolution of ASPM, a major determinant of cerebral cortical size
RT   in humans.";
RL   Hum. Mol. Genet. 13:489-494(2004).
CC   -!- FUNCTION: Probable role in mitotic spindle regulation and coordination
CC       of mitotic processes. May have a preferential role in regulating
CC       neurogenesis (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton,
CC       spindle {ECO:0000250}. Nucleus {ECO:0000250}. Note=The nuclear-
CC       cytoplasmic distribution could be regulated by the availability of
CC       calmodulin. Localizes to spindle poles during mitosis (By similarity).
CC       {ECO:0000250}.
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DR   EMBL; AAEX02025887; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AY485421; AAR98742.1; -; mRNA.
DR   RefSeq; NP_001184005.1; NM_001197076.1.
DR   STRING; 9612.ENSCAFP00000016776; -.
DR   PaxDb; P62286; -.
DR   PRIDE; P62286; -.
DR   GeneID; 480009; -.
DR   KEGG; cfa:480009; -.
DR   CTD; 259266; -.
DR   eggNOG; KOG0165; Eukaryota.
DR   HOGENOM; CLU_000237_0_0_1; -.
DR   InParanoid; P62286; -.
DR   OMA; CCCCYIF; -.
DR   OrthoDB; 482623at2759; -.
DR   TreeFam; TF351180; -.
DR   Proteomes; UP000002254; Chromosome 7.
DR   Bgee; ENSCAFG00000011403; Expressed in keratinocyte and 30 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR   GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007051; P:spindle organization; IEA:InterPro.
DR   Gene3D; 1.10.418.10; -; 2.
DR   Gene3D; 1.25.10.10; -; 1.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR031549; ASH.
DR   InterPro; IPR029955; ASPM.
DR   InterPro; IPR001715; CH-domain.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR22590:SF4; PTHR22590:SF4; 5.
DR   Pfam; PF15780; ASH; 1.
DR   Pfam; PF00307; CH; 1.
DR   Pfam; PF00612; IQ; 41.
DR   SMART; SM00033; CH; 2.
DR   SMART; SM00015; IQ; 65.
DR   SUPFAM; SSF47576; SSF47576; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF52540; SSF52540; 15.
DR   PROSITE; PS50021; CH; 2.
DR   PROSITE; PS50096; IQ; 38.
PE   2: Evidence at transcript level;
KW   Calmodulin-binding; Cell cycle; Cell division; Coiled coil; Cytoplasm;
KW   Cytoskeleton; Mitosis; Nucleus; Phosphoprotein; Reference proteome; Repeat.
FT   CHAIN           1..3469
FT                   /note="Abnormal spindle-like microcephaly-associated
FT                   protein homolog"
FT                   /id="PRO_0000191328"
FT   DOMAIN          913..1049
FT                   /note="Calponin-homology (CH) 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT   DOMAIN          1102..1253
FT                   /note="Calponin-homology (CH) 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT   DOMAIN          1258..1287
FT                   /note="IQ 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          1339..1370
FT                   /note="IQ 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          1385..1414
FT                   /note="IQ 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          1529..1560
FT                   /note="IQ 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          1574..1605
FT                   /note="IQ 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          1624..1653
FT                   /note="IQ 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          1647..1676
FT                   /note="IQ 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          1720..1749
FT                   /note="IQ 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          1743..1774
FT                   /note="IQ 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          1793..1822
FT                   /note="IQ 10"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          1816..1845
FT                   /note="IQ 11"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          1866..1895
FT                   /note="IQ 12"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          1889..1920
FT                   /note="IQ 13"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          1939..1970
FT                   /note="IQ 14"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          1962..1993
FT                   /note="IQ 15"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          2012..2041
FT                   /note="IQ 16"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          2035..2066
FT                   /note="IQ 17"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          2085..2116
FT                   /note="IQ 18"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          2108..2139
FT                   /note="IQ 19"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          2158..2189
FT                   /note="IQ 20"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          2181..2210
FT                   /note="IQ 21"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          2231..2262
FT                   /note="IQ 22"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          2304..2333
FT                   /note="IQ 23"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          2327..2358
FT                   /note="IQ 24"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          2377..2408
FT                   /note="IQ 25"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          2400..2431
FT                   /note="IQ 26"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          2450..2481
FT                   /note="IQ 27"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          2523..2554
FT                   /note="IQ 28"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          2681..2712
FT                   /note="IQ 29"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          2731..2762
FT                   /note="IQ 30"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          2851..2882
FT                   /note="IQ 31"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          2901..2930
FT                   /note="IQ 32"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          2924..2955
FT                   /note="IQ 33"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          2946..2977
FT                   /note="IQ 34"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          3021..3050
FT                   /note="IQ 35"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          3071..3102
FT                   /note="IQ 36"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          3173..3202
FT                   /note="IQ 37"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          3196..3227
FT                   /note="IQ 38"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1050..1069
FT                   /evidence="ECO:0000255"
FT   MOD_RES         273
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT   MOD_RES         276
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT   MOD_RES         361
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT   MOD_RES         386
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT   MOD_RES         420
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT   MOD_RES         599
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT   MOD_RES         1095
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT   CONFLICT        1687
FT                   /note="R -> Q (in Ref. 2; AAR98742)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        2175
FT                   /note="R -> G (in Ref. 2; AAR98742)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        2182
FT                   /note="Q -> E (in Ref. 2; AAR98742)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        2237
FT                   /note="C -> R (in Ref. 2; AAR98742)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        2522
FT                   /note="P -> R (in Ref. 2; AAR98742)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        2578
FT                   /note="E -> K (in Ref. 2; AAR98742)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        2588
FT                   /note="L -> V (in Ref. 2; AAR98742)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        2727
FT                   /note="K -> N (in Ref. 2; AAR98742)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        3205
FT                   /note="S -> A (in Ref. 2; AAR98742)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   3469 AA;  407600 MW;  633CA3CE3A949BD6 CRC64;
     MATRRAGRSW EVSPSGPRPA AGEAAAASPP VLSLSHFCRS PFLCFGDVRL GGSRTLPLLL
     HNPNDEAARV EVCRAPAAQQ GFSVSPRRFQ LQPKEKIVIS VNWTPLKEGR VRETVTFLVN
     DVLKHQAILL GNAEEQKKKK RSLWGTIKKK KMSASSNNKR ISSAQNVNKT FCVSQKADRV
     RNPLQACENL DVNEGCSPTE NNSLILEENK IPISPISPIF KECNGETSLP LSVRRSTTYI
     SLHARENGDL LKVEDASILE DFSFSEKVVN ETSFNSTNNI NDQTEENCKL ILTPACSSTL
     NITQSQGNFL SPDSFVKNSR AANNELEVVT CLSSNILMKD NSMPLHLESK SVHENYRKIL
     SPDSFINDNY GLNQDLESEP INPILSPNQF VKDNMAYTCI YQQTCKLSLS SNKNSQFSQS
     QDPRTNGILP CIPECQSSKS PKATFEEHRA LEMKSDCYSF TKNQPKFSAM QDISSCSQDK
     LTRRPILSAT ITKRKSNFTR ENQKETNKPK AKRCLNSVAG EFEKVTDNIK EKDGFQSCLP
     VIDPVFSKPK SYKIVVTPPS KTTLIARKRR SEGDREDANV RITATGHSEI QEIKRIHFSP
     VESKTSVLKK TKKMTTPISK HFNREKLNLK KKTDSRIYRT PNSKTSKKTK PIVAVAQSTL
     TFIKPLKTDI PRHPMPFAAK NMFYDERWKE KQEQGFTWWL NFILTPDDFT VKTNISEVNA
     ATLLLGVESQ HKISVPRAPT KDEMSLRAYT ARCRLNRLRR AACRLFTSEK MVKAIKKLEI
     EIEARRLIVR RDRHLWKDVG ERQKVLNWLL SYNPLWLRIG LETVFGELLS LEDNSDVTGL
     AVFILNRLLW NPDIAAEYRH PTVPHLYRDG HEEALSKFTL KKLLLLVCFL DYAKISKLID
     HDPCLFCKDA EFKTSKDILL AFSRDFLSGE GDLSRHLSLL GLPVNHVQTP FDEFDFAVTN
     LAVDLQCGVR LVRIMELLTR DWNLSKKLRM PAISRLQKMH NVDIVLQILR SQGIQLNDEH
     GNAILSKDIV DRHREKTLAL LWKIAFAFQV DISLNLDQLK EEIDFLKHTQ SMKKMSAQSC
     HSDVIINKKK DNRNSGSFEQ YSESIKLLME WVNAVCAFYN KKVENFTVSF SDGRVLCYLI
     HHYHPYYVPF DAICQRTTQT IECTQTGSVV LNSSSESDGS SLDLSLKAFD HENTSELYKE
     LLENEKKNFQ LVRSAVRDLG GIPAMINHSD MSNTIPDEKV VITYLSFLCS RLLDLCKETR
     AARLIQTTWR KYKLKTDMKR HQEQDKAARI IQSAIINFLT KRRLKKEISA ALAIQKYWRR
     FLAQRKLLML KKEKLEKVQN ESASIIQRYW RRYSTRKQFL KLRYYSIILQ SRIRMIIAVT
     SYKRYLWATV TIQRHWRASL RRKHDQQRYK MLKSSCLIIQ SMFRRWKRRK MQLQIKATRV
     LQRAFREWHV RKRAKEEKSA IVIQSWYRMH KELRKYVQIR SCVVIIQTRF RCLQAQKLYK
     RKKEAILTIQ KYYKAYLKGK MERTNYLQKR AAAIRLQTAF RRMKARNLYR QSRAACVLQS
     YWRMRQDRFR FLNLKKITTK LQAQVRKHQQ LQKYRKIKKA ALVIQIHFRA YVSAKKVLAS
     YQKTRSAVLV LQSAYRGMQA RKKFIHILTS IIKIQSCYRA YISRKRFLRL KNATVKLQSI
     VKMRQTRKRY LHWRAASLFI QRWYRSAKLA ALKRHQYVQM RESCIKLQAF VRGHLVRKQI
     RLQRQAAISL QSYFRMRKKR QYYLEIYKAT LVIQNYYRAY KAQVNQRKNF LQVKRAVTCL
     QAAYRGYKVR QLIKQQSIAA LKIQTAFRGY RERKKYQYVL QSTIKIQRWY RTCRTVRDVR
     TQFLKTRAAV ISLQCAFRGW KVRKQIRRER QAAVRIQSAF RMAKAQKQFK LLKTAALVIQ
     QHLRAWTAGK RQRMEYIELR EAALRLQSTW KGKRVRRQVQ KQHKCAVIIQ SNYRMYVQQK
     KWKIMKKAAR LIQMYYRAYS IGRKQRQLYL KTKAAAVVLQ SAYRSMKVRK KIKECNRAAV
     TIQSTYRAYK TKKNYTNCRA SAIIIQRWYR GTKIANHQRK EYLNLKKTAV KIQAIYRGIR
     VRRHNRHLHM AATVIQAMFK MHQAKMRYHK MRTAAVIIQV RYRAYREGKI QRAKYLTIMK
     AITVLQASFR GTRVRQTLRK MQSAATLIQS YYRRHRQQAY FTKLKKVTRT IQQRYRAVKE
     RNTQLQRYNK LRHSIICIQA GFRGMKARRH LKSMHLAATL IQRRFRTLRM RRRFLHLRKT
     AIWIQRKYRA TVCAKHYFQH FVRVQKAVIK IQSSYRGWMV RKKMQEVHRA ATAIQAAFRM
     HRANVKYQAL KHASVVIQQQ FRASRAAKLQ RQCYLQQRHS ALILQAAFRG MKARGHLKNM
     HSSATLIQST FRSLVVRKRF ISLKRATVFV QRKYRATICA RHHLHQFLKL KKAVITIQSS
     YRRLVAKKKL QEMHRAAVLI QATYRMHRTY VTFQTWKHAS ILIQQHYRTY RAAKLQRENS
     VPQRRSALII QAVYKGMKAR QLLREKHRAA IIIQSTYRMY RQYLFYQKIQ WATKVIQEKY
     RANKKKALQH SALRNAAAAC TEADFQDMIL RKPTQEQHQA ATIIQKHFKA SKVRKHYLHL
     RANVIFVQRR YRALTAVRTQ AVVCTQSSYR SCKVQEDMQH RHLAATRIQS FYRMHRAKLD
     YQAKKTAVAV IQNYFRSYIR VKVEREKFLA VQKSVRIIQA AFRGMKVRER LKSLSEVNMV
     ASAKQSAFYS CRTEAQCAAV HGSALRTQKW HGASLVTCSQ EAEYPQREAL VATQRAFCEM
     VTRKLETQKC AALRIQYFLQ MAVCRRRFVQ QKRAAVTLQQ YFRTWQTRRQ FLLYRKAAVV
     LQNHHRAFLS TKHQRQVYLQ IRSSIIMIQA RTRGFIQKRR FQKIKDSTIK IQAVWRSYKA
     RKYLHQVKAA CKIQAWYRYW KARKDYLAVL KAVKIIQGCF YTKLERRRFL NVRASTIIIQ
     RKWRAILSGR IACEHFLMIK RHQAACLIQA NFRRYKGRQV FLRQKSAALT IQRYIRARKA
     GKCQRIKYVE LKKSTVVLQA LVRGWLVRKR ILEQRTKIRL LHFTAAAYYH LSALKIQRAY
     KRHMAMKNAN KQVNAVICIQ RWFRTRLQQK RFAQKYPSIL TSQHEVPECM SQQNRAASVI
     QKAVRRFLLR KKQEKFNNAI SRIQSLWRGY SWRKKNDCTK IKAIRLSLQL VNREIREENK
     LYKRTALALH YLLTYKHLSA ILEALKHLEV VTRLSPLCCE NMAQSGAVSK IFVLIRSCNR
     SIPCMEVIRY AVQVLLNVAK YEKTTAAVSD VENCIDTLLD LLQMYREKPG DKVADKGGSI
     FTKTCCLLAV LLKTTNRASS VRSKSKVVDR IYSLYKLTAR KHKMNTERTL YKQKMNSSIS
     TPFIPETPVR TRIVSRLKPD WVLRRDNMEE ITNPLQAIQM VMDTLGIPY
 
 
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