PCX4_MOUSE
ID PCX4_MOUSE Reviewed; 1174 AA.
AC Q3UVY5; Q3TUC5; Q8BPG1; Q8VE84; Q9D8P3;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-JUN-2008, sequence version 2.
DT 25-MAY-2022, entry version 81.
DE RecName: Full=Pecanex-like protein 4;
DE AltName: Full=Pecanex homolog protein 4 {ECO:0000312|MGI:MGI:1914958};
GN Name=Pcnx4 {ECO:0000312|MGI:MGI:1914958}; Synonyms=Pcnxl4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Brain, Diencephalon, and Pancreas;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 688-1174 (ISOFORM 1).
RC STRAIN=Czech II; TISSUE=Eye, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q3UVY5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3UVY5-2; Sequence=VSP_034161;
CC -!- SIMILARITY: Belongs to the pecanex family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC36136.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAE23134.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAE36046.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK007829; BAB25289.1; -; mRNA.
DR EMBL; AK076035; BAC36136.1; ALT_INIT; mRNA.
DR EMBL; AK136802; BAE23134.1; ALT_INIT; mRNA.
DR EMBL; AK160852; BAE36046.1; ALT_INIT; mRNA.
DR EMBL; BC019573; AAH19573.1; -; mRNA.
DR EMBL; BC050256; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; NP_080603.2; NM_026327.3.
DR AlphaFoldDB; Q3UVY5; -.
DR STRING; 10090.ENSMUSP00000038916; -.
DR GlyGen; Q3UVY5; 3 sites.
DR PhosphoSitePlus; Q3UVY5; -.
DR PaxDb; Q3UVY5; -.
DR PRIDE; Q3UVY5; -.
DR ProteomicsDB; 288010; -. [Q3UVY5-1]
DR ProteomicsDB; 288011; -. [Q3UVY5-2]
DR GeneID; 67708; -.
DR KEGG; mmu:67708; -.
DR UCSC; uc007nvq.1; mouse. [Q3UVY5-2]
DR CTD; 64430; -.
DR MGI; MGI:1914958; Pcnx4.
DR eggNOG; KOG3604; Eukaryota.
DR InParanoid; Q3UVY5; -.
DR OrthoDB; 1243516at2759; -.
DR PhylomeDB; Q3UVY5; -.
DR BioGRID-ORCS; 67708; 3 hits in 71 CRISPR screens.
DR ChiTaRS; Pcnx4; mouse.
DR PRO; PR:Q3UVY5; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q3UVY5; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR039797; Pecanex.
DR InterPro; IPR007735; Pecanex_C.
DR PANTHER; PTHR12372; PTHR12372; 1.
DR Pfam; PF05041; Pecanex_C; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..1174
FT /note="Pecanex-like protein 4"
FT /id="PRO_0000339367"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 72..92
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 173..193
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 217..237
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 284..304
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 307..327
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 366..386
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 394..414
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 451..471
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 543..563
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 580..600
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 643..663
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 785..875
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 811..827
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 831..848
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 790
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1122
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1149
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 231..1174
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_034161"
FT CONFLICT 98
FT /note="P -> S (in Ref. 1; BAC36136/BAB25289 and 2;
FT BC050256)"
FT /evidence="ECO:0000305"
FT CONFLICT 798
FT /note="A -> G (in Ref. 2; AAH19573)"
FT /evidence="ECO:0000305"
FT CONFLICT 860
FT /note="V -> I (in Ref. 2; AAH19573)"
FT /evidence="ECO:0000305"
FT CONFLICT 958
FT /note="R -> H (in Ref. 2; AAH19573)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1174 AA; 131243 MW; 895133FFC31029D3 CRC64;
MSSDVPLLND YKQDFLLKRF PQTVLGGPRL KLGYCAPPYI YVNQIVLFLM PWALGGTGTL
LYQLDILRDY TAAALSGGLM VFTAAVIQLI SVYARSKPVV VRRMRTRDIL AEEDQHEFTS
CAGAETVKFL IPGKKYVANT VFHSVLAGLV CGLGTWYLLP NRVTLLYGSP GATAVLFVFG
WITLCIGEYS LIVNTATETA TFQTQDTYEI TPLMRPLYIF FFVSVDLAHR FIVNIPALEQ
MNQILHILFV LLPFLWALGT LPPPDALLFW AVEQVLEFGL GGSSMSTHLR LLVMFIVSAG
AAVVSYFIPS TVGVVLFMTG LGFLLSLNPS DVSMVFRYGV TRHRVGSSHE ARPGNSGHWF
PWKECFLFIA VLGMALLEAG LLHHYVSVPQ VSRSGAQAVV GYVLMVLLSI VWILRETQSI
YIFGIFRNPF YPKDIHAVSV FYDKQNKLLK IGAVRWILLT LVSPLAMVAF LALDSSLHGL
HSVSVSIGFT RAFRMVWQNT ETALLETVVV SAVHMVSSTD CWWNRSLDTG IRLLLIGIMR
DRLIQFITKL QFAVTVLLAL WTEKKQHRKT TTTLCVLNTV FAPFVLGIIV LSTLLSSPLL
PLFTLPVFLV GFPRPVQSWP GAVGTAACVC TDSVFYHQMV PRLTAALQTA MAAGSLGLLL
PGSHYLGRFE DRLIWIMILE CGYTYCCINV KGLELQETSC HTAEAQRVDE VFESAFQREH
PQVCSLNEHL ENVLTPCTVL PVKLYSDARN VLTGIIDSPD NLKEFKDDLI KVLVWVLIQH
CSKRPSTQEN KTENTGEASP ALPPAANSSP CPESLEDSES ANSDWSDGSI FDDEPAIKNR
KEKLQSKDLP CTKLPIPGSV DSQNPDDHSA GTGPKNDLYR TVILGLPAVD KGQREDVAYI
PLVEFSCSQS RLLSLPEEWR SNSTPRSKIL EMSALFPEDW YQFVLRQLEC FHSEEKSRVL
EEIAKDKALK DLYVHTVMAC YIGLFGIDNG VPSPGQLVRV YNGGLPWAGT LDWLSEKPEL
FHLVRKAFRY TLKLMVDKAS LGPIEDFKEL TNCLREYERD WYIGLVSEEQ WKRAILEEKP
CLFCLGYESS MGVYTSRVLM LQEMSVHIGK LNAEAVRGQW ANLSWELLYA TNDDEERYSI
QAHPLLLRNL TVQAADPPLG YPIFSSKPLP IHLC
