PCXA_ACAM1
ID PCXA_ACAM1 Reviewed; 482 AA.
AC B0CG09;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 1.
DT 25-MAY-2022, entry version 64.
DE RecName: Full=Proton extrusion protein PcxA {ECO:0000255|HAMAP-Rule:MF_01308};
GN Name=pcxA {ECO:0000255|HAMAP-Rule:MF_01308}; OrderedLocusNames=AM1_4479;
OS Acaryochloris marina (strain MBIC 11017).
OC Bacteria; Cyanobacteria; Synechococcales; Acaryochloridaceae;
OC Acaryochloris.
OX NCBI_TaxID=329726;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MBIC 11017;
RX PubMed=18252824; DOI=10.1073/pnas.0709772105;
RA Swingley W.D., Chen M., Cheung P.C., Conrad A.L., Dejesa L.C., Hao J.,
RA Honchak B.M., Karbach L.E., Kurdoglu A., Lahiri S., Mastrian S.D.,
RA Miyashita H., Page L., Ramakrishna P., Satoh S., Sattley W.M., Shimada Y.,
RA Taylor H.L., Tomo T., Tsuchiya T., Wang Z.T., Raymond J., Mimuro M.,
RA Blankenship R.E., Touchman J.W.;
RT "Niche adaptation and genome expansion in the chlorophyll d-producing
RT cyanobacterium Acaryochloris marina.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:2005-2010(2008).
CC -!- FUNCTION: Involved in light-induced Na(+)-dependent proton extrusion.
CC Also seems to be involved in CO(2) transport. {ECO:0000255|HAMAP-
CC Rule:MF_01308}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01308}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01308}.
CC -!- SIMILARITY: Belongs to the Cema family. {ECO:0000305}.
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DR EMBL; CP000828; ABW29456.1; -; Genomic_DNA.
DR RefSeq; WP_012164771.1; NC_009925.1.
DR AlphaFoldDB; B0CG09; -.
DR STRING; 329726.AM1_4479; -.
DR PRIDE; B0CG09; -.
DR EnsemblBacteria; ABW29456; ABW29456; AM1_4479.
DR KEGG; amr:AM1_4479; -.
DR eggNOG; ENOG502Z8DN; Bacteria.
DR HOGENOM; CLU_690401_0_0_3; -.
DR OMA; PANRDFI; -.
DR OrthoDB; 1605855at2; -.
DR Proteomes; UP000000268; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015078; F:proton transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01308; CemA; 1.
DR InterPro; IPR004282; CemA.
DR PANTHER; PTHR33650; PTHR33650; 1.
DR Pfam; PF03040; CemA; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Hydrogen ion transport; Ion transport;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..482
FT /note="Proton extrusion protein PcxA"
FT /id="PRO_0000346536"
FT TRANSMEM 265..285
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT TRANSMEM 359..379
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT TRANSMEM 406..426
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT TRANSMEM 442..462
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
SQ SEQUENCE 482 AA; 54781 MW; DCED882D119BBBDA CRC64;
MSSSSPNPFR RSLKFVEQWY RETPQRALDG AYEAARAIEE IEKKHFKGQP VPLRIRTESV
MTNYFQSEVQ KNLQFIQTRL REFKSSSLVV EVADKLKPPS IPPAPTPLDT PNTIDFTDEY
DVTSEEYSSE LVSPSIDAQG SLDKLAFIDA VLKRYRSASI QREAAAAASK AARASAPKSG
SEMKKNIPQP LPIQSAQNSL YESEFISDDI TEDPSKLDSS SFIPRSILRT ATRFRKELNP
DPGTEDDILN DFRNSRVRTR AAVSFVLGLM IVPLLTQQVS KNLVIGPFVD KLKGPEQIEI
RINPEIENEV LTELARFEER LKFESLTSPI PLSPAEIQFQ LKAKAEDLKE EYQWDLRQPL
KNAISDLFSL VALAIYFVLN RQKIAVLKSF FDEIIYGLSD SAKAFIIILF TDVFVGFHSP
HGWEVIVESV LSHFGLPQDR NFINMFIATF PVMLDTVFKY WIFRYLNQIS PSAVATYRNM
NE
