ID   PCXA_CROS5              Reviewed;         453 AA.
AC   B1X0Z7;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Proton extrusion protein PcxA {ECO:0000255|HAMAP-Rule:MF_01308};
GN   Name=pcxA {ECO:0000255|HAMAP-Rule:MF_01308}; OrderedLocusNames=cce_0287;
OS   Crocosphaera subtropica (strain ATCC 51142 / BH68) (Cyanothece sp. (strain
OS   ATCC 51142)).
OC   Bacteria; Cyanobacteria; Oscillatoriophycideae; Chroococcales;
OC   Aphanothecaceae; Crocosphaera; Crocosphaera subtropica.
OX   NCBI_TaxID=43989;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51142 / BH68;
RX   PubMed=18812508; DOI=10.1073/pnas.0805418105;
RA   Welsh E.A., Liberton M., Stoeckel J., Loh T., Elvitigala T., Wang C.,
RA   Wollam A., Fulton R.S., Clifton S.W., Jacobs J.M., Aurora R., Ghosh B.K.,
RA   Sherman L.A., Smith R.D., Wilson R.K., Pakrasi H.B.;
RT   "The genome of Cyanothece 51142, a unicellular diazotrophic cyanobacterium
RT   important in the marine nitrogen cycle.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:15094-15099(2008).
CC   -!- FUNCTION: Involved in light-induced Na(+)-dependent proton extrusion.
CC       Also seems to be involved in CO(2) transport. {ECO:0000255|HAMAP-
CC       Rule:MF_01308}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01308}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01308}.
CC   -!- SIMILARITY: Belongs to the Cema family. {ECO:0000305}.
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DR   EMBL; CP000806; ACB49638.1; -; Genomic_DNA.
DR   RefSeq; WP_009546780.1; NC_010546.1.
DR   AlphaFoldDB; B1X0Z7; -.
DR   STRING; 43989.cce_0287; -.
DR   EnsemblBacteria; ACB49638; ACB49638; cce_0287.
DR   KEGG; cyt:cce_0287; -.
DR   eggNOG; ENOG502Z8DN; Bacteria.
DR   HOGENOM; CLU_690401_0_0_3; -.
DR   OMA; PANRDFI; -.
DR   OrthoDB; 1605855at2; -.
DR   Proteomes; UP000001203; Chromosome circular.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015078; F:proton transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01308; CemA; 1.
DR   InterPro; IPR004282; CemA.
DR   PANTHER; PTHR33650; PTHR33650; 1.
DR   Pfam; PF03040; CemA; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Hydrogen ion transport; Ion transport;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..453
FT                   /note="Proton extrusion protein PcxA"
FT                   /id="PRO_1000165470"
FT   TRANSMEM        235..255
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        330..350
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        377..397
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        413..433
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   REGION          147..189
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   453 AA;  51966 MW;  F321AD36C8DC096F CRC64;
     MKFRSLIKKT SNWLTATPER SLDNAYKAAL KIKEIEDNHF GGKKVSKENA DYGDSVISYF
     KTEVNGYLQK INMGLGVFKT SRLFLNISNI QELPQERPTE RELQKNATTA AIIFEKLEFI
     DQVASKYQSR DTQEVYNGSL VLAKESSQDK ETQTLDNKST NQTNSKLSNN NKISSGQNDS
     RLESASQKTG VLPRSFINTL NKIKQEIDPK SGESEEQVLN KYRKSRLRTA LSIKFILLLI
     IVPLLTHQLT KTFLLTPIIH QYFQNHEQVV FINKDLEEEA FEELSHYEEI LRFQGLIGLR
     EPLTDEEVEE KVQEKAREIT EEYRAQGIDS IGNVFADLFS VTAFAIVIVS SRKEIEVLKS
     FLDEILYGLS DPAKAFLIIL FTDMFVGFHS PHGWEVILEG VARHFGLPEN QEFNFLFIAT
     FPVILDTVLK YWIFRYLNRI SPSAVATYKN MNE