ASPM_COLGU
ID ASPM_COLGU Reviewed; 3477 AA.
AC P62287;
DT 05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 23-FEB-2022, entry version 84.
DE RecName: Full=Abnormal spindle-like microcephaly-associated protein homolog;
GN Name=ASPM;
OS Colobus guereza (Mantled guereza) (Eastern black-and-white colobus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Colobus.
OX NCBI_TaxID=33548;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=14722158; DOI=10.1093/hmg/ddh055;
RA Evans P.D., Anderson J.R., Vallender E.J., Gilbert S.L., Malcom C.M.,
RA Dorus S., Lahn B.T.;
RT "Adaptive evolution of ASPM, a major determinant of cerebral cortical size
RT in humans.";
RL Hum. Mol. Genet. 13:489-494(2004).
CC -!- FUNCTION: Probable role in mitotic spindle regulation and coordination
CC of mitotic processes. May have a preferential role in regulating
CC neurogenesis (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton,
CC spindle {ECO:0000250}. Nucleus {ECO:0000250}. Note=The nuclear-
CC cytoplasmic distribution could be regulated by the availability of
CC calmodulin. Localizes to spindle poles during mitosis (By similarity).
CC {ECO:0000250}.
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DR EMBL; AY489022; AAR84355.1; -; Genomic_DNA.
DR EMBL; AY488995; AAR84355.1; JOINED; Genomic_DNA.
DR EMBL; AY488996; AAR84355.1; JOINED; Genomic_DNA.
DR EMBL; AY488997; AAR84355.1; JOINED; Genomic_DNA.
DR EMBL; AY488998; AAR84355.1; JOINED; Genomic_DNA.
DR EMBL; AY488999; AAR84355.1; JOINED; Genomic_DNA.
DR EMBL; AY489000; AAR84355.1; JOINED; Genomic_DNA.
DR EMBL; AY489001; AAR84355.1; JOINED; Genomic_DNA.
DR EMBL; AY489002; AAR84355.1; JOINED; Genomic_DNA.
DR EMBL; AY489003; AAR84355.1; JOINED; Genomic_DNA.
DR EMBL; AY489004; AAR84355.1; JOINED; Genomic_DNA.
DR EMBL; AY489005; AAR84355.1; JOINED; Genomic_DNA.
DR EMBL; AY489006; AAR84355.1; JOINED; Genomic_DNA.
DR EMBL; AY489007; AAR84355.1; JOINED; Genomic_DNA.
DR EMBL; AY489008; AAR84355.1; JOINED; Genomic_DNA.
DR EMBL; AY489009; AAR84355.1; JOINED; Genomic_DNA.
DR EMBL; AY489010; AAR84355.1; JOINED; Genomic_DNA.
DR EMBL; AY489011; AAR84355.1; JOINED; Genomic_DNA.
DR EMBL; AY489012; AAR84355.1; JOINED; Genomic_DNA.
DR EMBL; AY489013; AAR84355.1; JOINED; Genomic_DNA.
DR EMBL; AY489014; AAR84355.1; JOINED; Genomic_DNA.
DR EMBL; AY489015; AAR84355.1; JOINED; Genomic_DNA.
DR EMBL; AY489016; AAR84355.1; JOINED; Genomic_DNA.
DR EMBL; AY489017; AAR84355.1; JOINED; Genomic_DNA.
DR EMBL; AY489018; AAR84355.1; JOINED; Genomic_DNA.
DR EMBL; AY489019; AAR84355.1; JOINED; Genomic_DNA.
DR EMBL; AY489020; AAR84355.1; JOINED; Genomic_DNA.
DR EMBL; AY489021; AAR84355.1; JOINED; Genomic_DNA.
DR PRIDE; P62287; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007051; P:spindle organization; IEA:InterPro.
DR Gene3D; 1.10.418.10; -; 2.
DR Gene3D; 1.25.10.10; -; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR031549; ASH.
DR InterPro; IPR029955; ASPM.
DR InterPro; IPR001715; CH-domain.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR22590:SF4; PTHR22590:SF4; 6.
DR Pfam; PF15780; ASH; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00612; IQ; 39.
DR SMART; SM00033; CH; 2.
DR SMART; SM00015; IQ; 66.
DR SUPFAM; SSF47576; SSF47576; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR SUPFAM; SSF52540; SSF52540; 17.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50096; IQ; 39.
PE 3: Inferred from homology;
KW Calmodulin-binding; Cell cycle; Cell division; Coiled coil; Cytoplasm;
KW Cytoskeleton; Mitosis; Nucleus; Phosphoprotein; Repeat.
FT CHAIN 1..3477
FT /note="Abnormal spindle-like microcephaly-associated
FT protein homolog"
FT /id="PRO_0000191329"
FT DOMAIN 920..1056
FT /note="Calponin-homology (CH) 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT DOMAIN 1110..1261
FT /note="Calponin-homology (CH) 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT DOMAIN 1347..1378
FT /note="IQ 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1393..1422
FT /note="IQ 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1582..1613
FT /note="IQ 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1605..1634
FT /note="IQ 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1632..1661
FT /note="IQ 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1655..1684
FT /note="IQ 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1728..1757
FT /note="IQ 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1751..1782
FT /note="IQ 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1801..1830
FT /note="IQ 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1824..1853
FT /note="IQ 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1874..1903
FT /note="IQ 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1897..1928
FT /note="IQ 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1947..1978
FT /note="IQ 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1970..2001
FT /note="IQ 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2020..2049
FT /note="IQ 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2043..2074
FT /note="IQ 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2093..2124
FT /note="IQ 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2116..2147
FT /note="IQ 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2239..2270
FT /note="IQ 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2262..2293
FT /note="IQ 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2311..2342
FT /note="IQ 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2334..2365
FT /note="IQ 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2384..2415
FT /note="IQ 23"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2407..2438
FT /note="IQ 24"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2457..2488
FT /note="IQ 25"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2480..2511
FT /note="IQ 26"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2530..2561
FT /note="IQ 27"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2624..2653
FT /note="IQ 28"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2665..2696
FT /note="IQ 29"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2688..2719
FT /note="IQ 30"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2738..2767
FT /note="IQ 31"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2814..2845
FT /note="IQ 32"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2859..2890
FT /note="IQ 33"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2909..2938
FT /note="IQ 34"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2932..2963
FT /note="IQ 35"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2954..2985
FT /note="IQ 36"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 3029..3060
FT /note="IQ 37"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 3079..3110
FT /note="IQ 38"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 3204..3235
FT /note="IQ 39"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 417..436
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 563..583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1057..1076
FT /evidence="ECO:0000255"
FT COMPBIAS 417..432
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 283
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 367
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 392
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 425
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 605
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 1103
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
SQ SEQUENCE 3477 AA; 409686 MW; 4C88F5A815534103 CRC64;
MANRRVGRGC WEVSPTERRP PAGLRGPATE EEASSPPVLS LSHFCRSPFL CFGDVLLGDS
RTVPLALDNP NEEVAEVKIS HFPAADLGFS VSQRCFVLQP KDKIVISVDW TPFKEGRVRE
IMTFLINDVL KHQAILLGNA EKQKKKKRSL WDTIKKKKIS ASTSHNRRVS NIQNVNKTFS
VSQKVNRVRS PLQACENLAV NEGGLPTENN SLTLEENKIP VSPISPAFNE CHGATCLPLS
VRRSTTYSSL HASENRELLN VDNTNVSKVS FNEKAVAETT FNSMNVSGQS GENSKLILTP
NYSSTLNVTQ SQINFLSPDS FVNNSHGANN ELELVTCLSS DMFMTDNSKP VHLQSTTAHE
IYQKILSPDS FIKDNYGLNQ DLESESVNLI LSPNQFLKDN MAYMCTSQQT CKVPLTNENS
QVPQSPQDWS KSEVSPCIPE CQGSKSPKAI FEELVEMKSD YYSFIKQNNP KFSAVQDISS
HSHNKQPKRR PILSATVTKR KPTCTRENQT EINKPKAKRC LNSAVGGHEK VINNQKEKED
FHSYLPVIDP VLSKSKSYKN QIMPSSTTAS VARKRKSDES MEDANVRVAV TEHTEVREIK
RIHFSPSESK TSAVKKTKNV ITPISKCISN REKLNLKKKT DLLIFKTPIS KTNRRTKPII
AVAQSNLTFI KPLKTDIPRH PMPFAAKNMF YDERWKEKQE QGFTWWLNFI LTPDDFTVKT
NISEVNAATL LLGVENQHKI SVPRAPTKEE MSLRAYTARC RLNRLRRAAC RLFTSEKMVK
AIKKLEIEIE ARRLIVRKDR HLWKDVGERQ KVLNWLLSYN PLWLRIGLET IYGELISLED
NSDVTGLAMF ILNRLLWNPD IAAEYRHPTV PHLYRDGHEG ALSKFTLKKL LLLVCFLDYA
KISKLIDHDP CLFCKDAEFK ASKEILLAFS RDFLSGEGDL SRHLGLLGLP VNHVQTPFDE
FDFAITNLAV DLQCGVRLVR TMELLTQNWS LSKKLRIPAI SRLQKMHNVD IVLQVLKSRG
IELSDEHGNT ILSKDIVDRH REKTLRLLWK IAFAFQVDIS LNLDQLKEEI AFLKHTQSIK
RTISLLSCHS DALINKKKGK RDSGSFEQYS ENIKLLMDWV NAVCAFYNKK VENFTVSFSD
GRVLCYLIHH YHPCYVPFDA ICQRTTQTVE CTQTGSVVLN SSSESDDSSL DMSLKAFDHE
NTSELYKELL ENEKKNFHLV RSAVRDLGGI PAMINHSDMS NTIPDEKVVI TYLSFLCARL
LDLRKEIRAA RLIQTTWRKY KLKTDLKRHQ ERDKAARIIQ SAVINFLAKQ RLRKRVNAAL
IIQKYWRRVL AQRKLLILKK EKLEKVQNKA ASLIQGYWRR YSTRKRFLKL KYYSIILQSR
IRMIIAVTSY KRYLWATVTI QRHWRAYLRR KQDQQRYEML KSSSLIIQSM FRKWKQRKMQ
SQVKATVILQ RAFREWHLRK RAKEENSAIV IQSWYRMHKE LRKYIYIRSC VIVIQKRFRC
FQAQKLYKRK KESILTIQKY YKAYLKGKIE RTNYLQKRAA AIQLQAAFRR LKAHNLCRQI
RAACVIQSYW RMRQDRVRFL NLKKTIIKFQ AHIRKHQQLQ KYKKMKKAAV IIQTHFRAYI
FARKVLASYQ KTRSAVIVLQ SAYRGMQARK MYIHILTSVI KIQSYYRAYV SKKEFLSLKN
ATIKLQSIVK MKQTRKQYLH LRAAALFIQQ CYRSKKIATQ KREEYMQMRE SCIKLQAFVR
GYLVRKQMRL QRKAVISLQS YFRMRKARQY YLKMYKAIIV IQNYYHAYKA QVNQRKKFLR
VKKAATCLQA AYRGYKIRQL IKQQSIAAVK IQSAFRGYNK RVKYQSVLQS IIKIQRWYRA
YKTLHDTRTH FLKTKAAVVS LQSAYRGWKV RKQIRREHQA ALKIQSAFRM AKAQKQFRLF
KTAALVIQQN FRAWTAGRKQ RMEYIELRHA VLILQSMWKG KTLRRQLQRQ HKCAIIIQSY
YRMHVQQKKW KIMKKAALLI QKYYKAYSIG REQHHLYLKT KAAVVTLQSA YRGMKVRKRI
KDCNKAAVTI QSKYRAYKTK KKYATYRASA IIIQRWYRGI KITHRQHKEY LNLKKTAIKI
QSVYRGIRVR RHIQHMHRAA TYIKAMFKMH QSRISYHTMR KAAIVIQVRF RAYYQGKMQR
EKYLTILKAV KILQASFRGV RVRWTLRKMQ IAATLIQSNY RRYKQQTYFN KLKKITKTIQ
QRYRAVKERN IQFQRYNKLR HSVIYIQAIF RGKKARRHLK MMHVAATLIQ RRFRTLMMRR
RFLSLKKTAV WIQRKYRAHL CTKHHLQFLQ VQNAVIKIQS SYRRWMIRKK MREMHRAATF
IQATFRMQRV HMRYQALKQA SVVIQQQYQA NRAAKLQRQH YLRQRHSAVI LQAAFRGMKT
RRHLKSMHSS ATLIQSRFRS LLVRRRFISL KKATIFVQRK YRATICAKHK LHQFLQLRKA
AITVQSSYRR LMVKKKLQEM QRAAVLIQAT FRMHRTYVTF QTWKQASILI QQHYRTYRAA
KLQKENYIRQ WHSAVVIQAA YKGMKARQHL REKHKAAIII QSTYRMHRQY CFYQKLQWAT
KIIQEKYRAN KKKQKALQHN ELKKETCVQA SFQDMNMQKQ IQEQHQAAII IQKHCKAFKI
RKHYLHLRAT VVSIQRRYRK LTVVRTQAVI CIQSYYRGFK VRRDIQNMHR AATLIQSFYR
MHRAKVDYQT KKTAIVVIQN YYRLYIRVKT ERKIFLAVQK SVRTIQAAFR GMKVRQKLKN
ISEEKMAAIV NQSALCCYRS KTQYEAVQSE GVTIQEWYKA SGLACSQEAE YHSQSRAAVT
IQKAFRRMVT RKVETQKCAA LRIQFFLQMA VYRRRFVQQK RAAITLQHYF RTWQTRKQFL
LYRKAAVVLQ NHYRAFLSAK HQRQVYLQIR SSVIIIQARS KGFIQKRKFQ EIKNSTIKIQ
AMWRRYRAKK YLCKVKAACK IQAWYRCWRA HKEYLAILKA VKIIQGGFYT KLERTWFLNV
RASAIIIQRK WRAILSAKIA HEHFLMIKRH RAACLIQAHY RGYKERQVFL RQKSAALIIQ
KYIRAREAGK RERIKYIEFK KSTVILQALV RGWLVRKRIL EQRTKIRLLH FTAAAYYHLN
ALRIQRAYKL YLAVKNANKQ VNSVICIQRW FRARLQQKKF IQKYYSIEKI EHEGQECLSQ
RNRAASVIQK AVRHFVLRKK QEKFTSGIIK IQALWRGYSW RKKNDCTKIK AIRLSLQVVN
REIREENKLY KRTALALHYL LTYKHLSAIL EALKHLEVVT RLSPLCCENM AQSGAISKIF
VLIRSCNRSV PCMEVIRYAV QVLLNVSKYE KTTSAVYDVE NCVDTLLELL QIYREKPGNK
VADKGGSIFT KTCCLLAILL KTTNRASDVR SRSKVVDRIY SLYKLTAHKH KMNTERILHK
QKKNSSISIP FIPETPVRTR IVSRLKPDWV LRRDNMEEIT NPLQAIQMVM DTLGIPY
