ID   PCXA_GLOC7              Reviewed;         457 AA.
AC   B7KHV5;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Proton extrusion protein PcxA {ECO:0000255|HAMAP-Rule:MF_01308};
GN   Name=pcxA {ECO:0000255|HAMAP-Rule:MF_01308};
GN   OrderedLocusNames=PCC7424_3669;
OS   Gloeothece citriformis (strain PCC 7424) (Cyanothece sp. (strain PCC
OS   7424)).
OC   Bacteria; Cyanobacteria; Oscillatoriophycideae; Chroococcales;
OC   Aphanothecaceae; Gloeothece; Gloeothece citriformis.
OX   NCBI_TaxID=65393;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 7424;
RX   PubMed=21972240; DOI=10.1128/mbio.00214-11;
RA   Bandyopadhyay A., Elvitigala T., Welsh E., Stockel J., Liberton M., Min H.,
RA   Sherman L.A., Pakrasi H.B.;
RT   "Novel metabolic attributes of the genus Cyanothece, comprising a group of
RT   unicellular nitrogen-fixing Cyanobacteria.";
RL   MBio 2:E214-E214(2011).
CC   -!- FUNCTION: Involved in light-induced Na(+)-dependent proton extrusion.
CC       Also seems to be involved in CO(2) transport. {ECO:0000255|HAMAP-
CC       Rule:MF_01308}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01308}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01308}.
CC   -!- SIMILARITY: Belongs to the Cema family. {ECO:0000305}.
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DR   EMBL; CP001291; ACK72052.1; -; Genomic_DNA.
DR   RefSeq; WP_015955645.1; NC_011729.1.
DR   AlphaFoldDB; B7KHV5; -.
DR   STRING; 65393.PCC7424_3669; -.
DR   EnsemblBacteria; ACK72052; ACK72052; PCC7424_3669.
DR   KEGG; cyc:PCC7424_3669; -.
DR   eggNOG; ENOG502Z8DN; Bacteria.
DR   HOGENOM; CLU_690401_0_0_3; -.
DR   OMA; PANRDFI; -.
DR   OrthoDB; 1605855at2; -.
DR   Proteomes; UP000002384; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015078; F:proton transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01308; CemA; 1.
DR   InterPro; IPR004282; CemA.
DR   PANTHER; PTHR33650; PTHR33650; 1.
DR   Pfam; PF03040; CemA; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Hydrogen ion transport; Ion transport;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..457
FT                   /note="Proton extrusion protein PcxA"
FT                   /id="PRO_1000140910"
FT   TRANSMEM        239..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        332..352
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        368..390
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        417..437
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
SQ   SEQUENCE   457 AA;  52294 MW;  E09D88E8FEB744B2 CRC64;
     MKLSRIVRGA NQWLSKTPER ALDQAYRAAL KIKELEDKHF QGKKVSPDTA QYGDSVMTYF
     EAELQGYLQT IKVRLGVFKT SRLFTSLSEP THPRDERIAL EQDSHGNRLL QKLKFIDDVI
     SKYKTNEIVT AHSSDNGVIR GSELTPLNQQ QVVIEANGKV PPPKKTNPQP AKKLTNLTVD
     EPKNKLDSAT DKTGVLPRSF LNTINRIKQE IDPKSEETEE AVLKRFRTSR YKTAISIKFI
     LLLIIVPLLT HQLTKTFFLT PVVEHYFSQH EQVVFINKDL EEEAFVELRS FEEALHFKSL
     IGIIPKLTQE EIEQEVRLKA EEISESYRLE GINAISNVFA DIFSLIAFGV VIATSRKEIE
     IVKSFLDGIL YSLSDSAKAF LIILFTDMFV GFHSPHGWEV ILEGVARHFG LPENRDFNFL
     FIATFPVILD TVLKYWIFRY LNRISPSAVA TYRNMNE