ID   PCXA_MICAN              Reviewed;         445 AA.
AC   B0JI44;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Proton extrusion protein PcxA {ECO:0000255|HAMAP-Rule:MF_01308};
GN   Name=pcxA {ECO:0000255|HAMAP-Rule:MF_01308}; OrderedLocusNames=MAE_57840;
OS   Microcystis aeruginosa (strain NIES-843 / IAM M-2473).
OC   Bacteria; Cyanobacteria; Oscillatoriophycideae; Chroococcales;
OC   Microcystaceae; Microcystis.
OX   NCBI_TaxID=449447;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIES-843 / IAM M-247;
RX   PubMed=18192279; DOI=10.1093/dnares/dsm026;
RA   Kaneko T., Nakajima N., Okamoto S., Suzuki I., Tanabe Y., Tamaoki M.,
RA   Nakamura Y., Kasai F., Watanabe A., Kawashima K., Kishida Y., Ono A.,
RA   Shimizu Y., Takahashi C., Minami C., Fujishiro T., Kohara M., Katoh M.,
RA   Nakazaki N., Nakayama S., Yamada M., Tabata S., Watanabe M.M.;
RT   "Complete genomic structure of the bloom-forming toxic cyanobacterium
RT   Microcystis aeruginosa NIES-843.";
RL   DNA Res. 14:247-256(2007).
CC   -!- FUNCTION: Involved in light-induced Na(+)-dependent proton extrusion.
CC       Also seems to be involved in CO(2) transport. {ECO:0000255|HAMAP-
CC       Rule:MF_01308}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01308}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01308}.
CC   -!- SIMILARITY: Belongs to the Cema family. {ECO:0000305}.
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DR   EMBL; AP009552; BAG05606.1; -; Genomic_DNA.
DR   RefSeq; WP_002787816.1; NC_010296.1.
DR   AlphaFoldDB; B0JI44; -.
DR   SMR; B0JI44; -.
DR   STRING; 449447.MAE_57840; -.
DR   PaxDb; B0JI44; -.
DR   EnsemblBacteria; BAG05606; BAG05606; MAE_57840.
DR   KEGG; mar:MAE_57840; -.
DR   eggNOG; ENOG502Z8DN; Bacteria.
DR   HOGENOM; CLU_690401_0_0_3; -.
DR   OMA; PANRDFI; -.
DR   OrthoDB; 1605855at2; -.
DR   BioCyc; MAER449447:MAE_RS25230-MON; -.
DR   Proteomes; UP000001510; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015078; F:proton transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01308; CemA; 1.
DR   InterPro; IPR004282; CemA.
DR   PANTHER; PTHR33650; PTHR33650; 1.
DR   Pfam; PF03040; CemA; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Hydrogen ion transport; Ion transport;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..445
FT                   /note="Proton extrusion protein PcxA"
FT                   /id="PRO_1000086079"
FT   TRANSMEM        227..247
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        322..342
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        369..389
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        405..425
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
SQ   SEQUENCE   445 AA;  51317 MW;  145B767876F9BC35 CRC64;
     MNLNRILQGV NQWLLQTPER SLDEAYHAAL KIKEIEDKHF QGRKVANEFS NYGSSTNSYF
     IAEVKGYLQK IKVRLTEFKA SRSIVNTFGP NQPTINNGVI TVTTDVCLKK LQFIDSIIGK
     YQDNYWQEDI QDVPKSIQNR NFEQETAKNK TSRNRSFLAA GSIEDEEIIK SNKSQKATEK
     PGVLPRSFVN TFNRIKQEID PQAEESEEAV LKKFRNSRYK TAISLKFILL LIIVPLLTQQ
     LTKTFLITPL VNKYFQQQEQ FIFINQDLEE EAFSELRRFE EALHFRGMIG LAPKLSNEEI
     EGEITKKAAV LSEEFRQRGL NAIANIFADI CSLIAFGFVV AFSRREIEIV KSFLDGILYN
     LSDSAKAFLI ILFTDIFVGF HSPHGWEVIL EGLSRHFGLP ENRQFNFLFI ATFPVILDTV
     LKYWIFRYLN RISPSAVATY RNMNE