ID   PCXA_NOSS1              Reviewed;         467 AA.
AC   Q8YWE0;
DT   06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Proton extrusion protein PcxA {ECO:0000255|HAMAP-Rule:MF_01308};
GN   Name=pcxA {ECO:0000255|HAMAP-Rule:MF_01308}; OrderedLocusNames=all1673;
OS   Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576).
OC   Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Nostoc.
OX   NCBI_TaxID=103690;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 7120 / SAG 25.82 / UTEX 2576;
RX   PubMed=11759840; DOI=10.1093/dnares/8.5.205;
RA   Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A.,
RA   Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M.,
RA   Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M.,
RA   Takazawa M., Yamada M., Yasuda M., Tabata S.;
RT   "Complete genomic sequence of the filamentous nitrogen-fixing
RT   cyanobacterium Anabaena sp. strain PCC 7120.";
RL   DNA Res. 8:205-213(2001).
CC   -!- FUNCTION: Involved in light-induced Na(+)-dependent proton extrusion.
CC       Also seems to be involved in CO(2) transport. {ECO:0000255|HAMAP-
CC       Rule:MF_01308}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01308}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01308}.
CC   -!- SIMILARITY: Belongs to the Cema family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BA000019; BAB78039.1; -; Genomic_DNA.
DR   PIR; AC2015; AC2015.
DR   RefSeq; WP_010995842.1; NZ_RSCN01000013.1.
DR   AlphaFoldDB; Q8YWE0; -.
DR   SMR; Q8YWE0; -.
DR   STRING; 103690.17135493; -.
DR   EnsemblBacteria; BAB78039; BAB78039; BAB78039.
DR   KEGG; ana:all1673; -.
DR   eggNOG; ENOG502Z8DN; Bacteria.
DR   OMA; PANRDFI; -.
DR   OrthoDB; 1605855at2; -.
DR   Proteomes; UP000002483; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015078; F:proton transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01308; CemA; 1.
DR   InterPro; IPR004282; CemA.
DR   PANTHER; PTHR33650; PTHR33650; 1.
DR   Pfam; PF03040; CemA; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Hydrogen ion transport; Ion transport;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..467
FT                   /note="Proton extrusion protein PcxA"
FT                   /id="PRO_0000216668"
FT   TRANSMEM        244..263
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        348..365
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        378..400
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        426..448
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   REGION          146..167
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          186..205
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   467 AA;  53641 MW;  C5350E89EE68C1CA CRC64;
     MPTMRNSIFS EKIYPILLSA YRWYLRTPER SLEEAYKAAL NIKAIEDEHF NGNKIDFNSA
     IYSNSVMDYF ESDLAQELKT ARMRLTEFRF SRWFSNESHQ KAARKAGIEY PSSNVTLEKL
     KFIDEVISKY IITDYEIVAP SGVSESQVRT TSSQPPENPS LTDALRTNDI NKNNLVERIY
     TPTSPPQLIK QRTEQSKKSR GKADTTGILP RSILSTIGRL QIELDPNAEQ DVINNFRQAQ
     KRSIISIRFI LLIIIVPLLT HQLSKALIVS PIFNHFKNDH TEQIFLNSEM EEEALSTLHR
     FEERIKFENL ISNAPPLSAE AIETQIKEKA EELAAEFRGE SSNAIKNVFA DIFSVGAFIW
     LLLVSKPSIM VLKEFFDNVV YGLSDSAKAF IIILFTDVFV GFHSPHGWEV ILEGLSRHWG
     LPANRDFIFL FIATFPVILD TIFKYWIFRY LNRISPSAVA TYRNMNE