ID   PCXA_PARMW              Reviewed;         382 AA.
AC   Q7U6W9;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Proton extrusion protein PcxA {ECO:0000255|HAMAP-Rule:MF_01308};
GN   Name=pcxA {ECO:0000255|HAMAP-Rule:MF_01308}; OrderedLocusNames=SYNW1217;
OS   Parasynechococcus marenigrum (strain WH8102).
OC   Bacteria; Cyanobacteria; Synechococcales; Prochlorococcaceae;
OC   Parasynechococcus; Parasynechococcus marenigrum.
OX   NCBI_TaxID=84588;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WH8102;
RX   PubMed=12917641; DOI=10.1038/nature01943;
RA   Palenik B., Brahamsha B., Larimer F.W., Land M.L., Hauser L., Chain P.,
RA   Lamerdin J.E., Regala W., Allen E.E., McCarren J., Paulsen I.T.,
RA   Dufresne A., Partensky F., Webb E.A., Waterbury J.;
RT   "The genome of a motile marine Synechococcus.";
RL   Nature 424:1037-1042(2003).
CC   -!- FUNCTION: Involved in light-induced Na(+)-dependent proton extrusion.
CC       Also seems to be involved in CO(2) transport. {ECO:0000255|HAMAP-
CC       Rule:MF_01308}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01308}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01308}.
CC   -!- SIMILARITY: Belongs to the Cema family. {ECO:0000305}.
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DR   EMBL; BX569692; CAE07732.1; -; Genomic_DNA.
DR   RefSeq; WP_011128082.1; NC_005070.1.
DR   AlphaFoldDB; Q7U6W9; -.
DR   STRING; 84588.SYNW1217; -.
DR   EnsemblBacteria; CAE07732; CAE07732; SYNW1217.
DR   KEGG; syw:SYNW1217; -.
DR   eggNOG; ENOG502Z8DN; Bacteria.
DR   HOGENOM; CLU_690401_0_0_3; -.
DR   OMA; HSPEGWT; -.
DR   OrthoDB; 1605855at2; -.
DR   Proteomes; UP000001422; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015078; F:proton transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01308; CemA; 1.
DR   InterPro; IPR004282; CemA.
DR   PANTHER; PTHR33650; PTHR33650; 1.
DR   Pfam; PF03040; CemA; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Hydrogen ion transport; Ion transport;
KW   Membrane; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..382
FT                   /note="Proton extrusion protein PcxA"
FT                   /id="PRO_0000293505"
FT   TRANSMEM        162..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        257..277
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        305..325
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        340..360
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
SQ   SEQUENCE   382 AA;  42691 MW;  2D1026DE03A48547 CRC64;
     MAARNWIGLF SRGEGNNLTN ALERGYEAAL LIQSLELEFY ADRKVRPELE LSVPRSVQAT
     VLRRFHAALQ ICRSSLSTVT PNRGQLDPQE LRQLQLIETV VSRYSGKRSS SKSGMSTAPE
     LLPRSLLGVF DSVRRQLDPS SEESVVAGFR RRRDSTLASL RILLLLVLVP LLVQQVSNTY
     IVGPAVERLS PDLSFLSYPK PQLEEVAVEK LRIYKEELEF DALLKGQEPL SSDLLVIKLR
     ERAQELKQEA DQESVQAIKN VLADLAGLMA FVVVCLVSRD QLRVLRGFLD EAIYGLSDSA
     KAFAIILFTD IFVGYHSPEG WTVLLDGIAH HFGLPTQENF ILLFIATFPV ILATIFKYWI
     FRYLNRVSPS SVATLKGMNG GG