ID   PCXA_PROM3              Reviewed;         376 AA.
AC   A2C9Q5;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Proton extrusion protein PcxA {ECO:0000255|HAMAP-Rule:MF_01308};
GN   Name=pcxA {ECO:0000255|HAMAP-Rule:MF_01308}; OrderedLocusNames=P9303_14691;
OS   Prochlorococcus marinus (strain MIT 9303).
OC   Bacteria; Cyanobacteria; Synechococcales; Prochlorococcaceae;
OC   Prochlorococcus.
OX   NCBI_TaxID=59922;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MIT 9303;
RX   PubMed=18159947; DOI=10.1371/journal.pgen.0030231;
RA   Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S.,
RA   Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M.,
RA   Richardson P., Chisholm S.W.;
RT   "Patterns and implications of gene gain and loss in the evolution of
RT   Prochlorococcus.";
RL   PLoS Genet. 3:2515-2528(2007).
CC   -!- FUNCTION: Involved in light-induced Na(+)-dependent proton extrusion.
CC       Also seems to be involved in CO(2) transport. {ECO:0000255|HAMAP-
CC       Rule:MF_01308}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01308}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01308}.
CC   -!- SIMILARITY: Belongs to the Cema family. {ECO:0000305}.
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DR   EMBL; CP000554; ABM78215.1; -; Genomic_DNA.
DR   AlphaFoldDB; A2C9Q5; -.
DR   STRING; 59922.P9303_14691; -.
DR   EnsemblBacteria; ABM78215; ABM78215; P9303_14691.
DR   KEGG; pmf:P9303_14691; -.
DR   HOGENOM; CLU_690401_0_0_3; -.
DR   OMA; HSPEGWT; -.
DR   Proteomes; UP000002274; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015078; F:proton transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01308; CemA; 1.
DR   InterPro; IPR004282; CemA.
DR   PANTHER; PTHR33650; PTHR33650; 1.
DR   Pfam; PF03040; CemA; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Hydrogen ion transport; Ion transport;
KW   Membrane; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..376
FT                   /note="Proton extrusion protein PcxA"
FT                   /id="PRO_0000293496"
FT   TRANSMEM        150..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        251..271
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        299..319
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        334..354
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
SQ   SEQUENCE   376 AA;  42637 MW;  1FAFCE9E7002A05A CRC64;
     MRTFGEARSI DINNDLERGY EAALLIQTLE LEYYGDRPIR PNLQLSVPRS LQSTILRKFH
     TAVNICRLTF EAIKPNISQL DSQEYRKFQL IETIVNRYAP KRSSRSTSMS RAPDPLPRSL
     LGLVDKVRRQ LDPTSEATLV AGFRRRRDST LISLKIILLL ILVPLLVQQM SRTYLITPAI
     DYLAPDLPFL SYPKPQLEEQ AVEKLRVFKA EIEFDALLKG DSIPSQDELQ KALVIKANQL
     KDEADKESTH AVKNVLADIA ALIAFAFVCI INREELRVLR GFLDEAVYGL SDSAKAFAII
     LFTDMFVGFH SPEGWQVLLQ GIANHFGFPA RENFILLFIA TFPVILATIF KYWIFRYLNR
     VSPSSVATLR GMNGSS