ID   PCXA_RIPO1              Reviewed;         448 AA.
AC   B7K2V6;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Proton extrusion protein PcxA {ECO:0000255|HAMAP-Rule:MF_01308};
GN   Name=pcxA {ECO:0000255|HAMAP-Rule:MF_01308};
GN   OrderedLocusNames=PCC8801_3701;
OS   Rippkaea orientalis (strain PCC 8801) (Cyanothece sp. (strain PCC 8801)).
OC   Bacteria; Cyanobacteria; Oscillatoriophycideae; Chroococcales;
OC   Aphanothecaceae; Rippkaea; Rippkaea orientalis.
OX   NCBI_TaxID=41431;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 8801;
RX   PubMed=21972240; DOI=10.1128/mbio.00214-11;
RA   Bandyopadhyay A., Elvitigala T., Welsh E., Stockel J., Liberton M., Min H.,
RA   Sherman L.A., Pakrasi H.B.;
RT   "Novel metabolic attributes of the genus Cyanothece, comprising a group of
RT   unicellular nitrogen-fixing Cyanobacteria.";
RL   MBio 2:E214-E214(2011).
CC   -!- FUNCTION: Involved in light-induced Na(+)-dependent proton extrusion.
CC       Also seems to be involved in CO(2) transport. {ECO:0000255|HAMAP-
CC       Rule:MF_01308}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01308}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01308}.
CC   -!- SIMILARITY: Belongs to the Cema family. {ECO:0000305}.
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DR   EMBL; CP001287; ACK67657.1; -; Genomic_DNA.
DR   RefSeq; WP_012596915.1; NC_011726.1.
DR   AlphaFoldDB; B7K2V6; -.
DR   STRING; 41431.PCC8801_3701; -.
DR   EnsemblBacteria; ACK67657; ACK67657; PCC8801_3701.
DR   KEGG; cyp:PCC8801_3701; -.
DR   eggNOG; ENOG502Z8DN; Bacteria.
DR   HOGENOM; CLU_690401_0_0_3; -.
DR   OMA; PANRDFI; -.
DR   OrthoDB; 1605855at2; -.
DR   Proteomes; UP000008204; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015078; F:proton transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01308; CemA; 1.
DR   InterPro; IPR004282; CemA.
DR   PANTHER; PTHR33650; PTHR33650; 1.
DR   Pfam; PF03040; CemA; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Hydrogen ion transport; Ion transport;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..448
FT                   /note="Proton extrusion protein PcxA"
FT                   /id="PRO_1000140911"
FT   TRANSMEM        231..251
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        323..343
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        372..392
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        408..428
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
SQ   SEQUENCE   448 AA;  51343 MW;  F0DD15C71374B275 CRC64;
     MKLKSLIKST SDWFSSTPER ALNRAYKSAL KIQEIETKHF RGQKVSRENA DYGASVITYF
     ETEVQSYLQK INMELTVFKA SRLFLSLSNL QDTENNLGTG KVKSEQETTA IIIFDKLKFI
     DEVIAKYKSN AIEKNVSNNV AIIAASERNP EVTNSAPSGK KSTKVKDQGV KNKTINFESA
     SQKTGVLPRS FMNTLNKIKQ EIDPKSGESE EQVLTKYRKS RYRTALSIKF ILLLIIIPLL
     IHQLTKTFFL IPVVEQYFSR HEQVIFINRD LEDEALEELQ HYEETLHFRG LIGLGPELSP
     EKIEQEVKQK AGEITEEYRR HGIDSIANIF ADLFSFIAFV LVLVNSKKEI EVVKSFLDEI
     LYGLSDPAKA FLIILFTDMF VGFHSPHGWE VILEGVAHHF GLPENREFNF LFIATFPVIL
     DTVLKYWIFR YLNRISPSAV ATYKNMNE