ID   PCXA_SYNJA              Reviewed;         460 AA.
AC   Q2JRR7;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Proton extrusion protein PcxA {ECO:0000255|HAMAP-Rule:MF_01308};
GN   Name=pcxA {ECO:0000255|HAMAP-Rule:MF_01308}; OrderedLocusNames=CYA_2560;
OS   Synechococcus sp. (strain JA-3-3Ab) (Cyanobacteria bacterium Yellowstone
OS   A-Prime).
OC   Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus;
OC   unclassified Synechococcus.
OX   NCBI_TaxID=321327;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JA-3-3Ab;
RX   PubMed=18059494; DOI=10.1038/ismej.2007.46;
RA   Bhaya D., Grossman A.R., Steunou A.-S., Khuri N., Cohan F.M., Hamamura N.,
RA   Melendrez M.C., Bateson M.M., Ward D.M., Heidelberg J.F.;
RT   "Population level functional diversity in a microbial community revealed by
RT   comparative genomic and metagenomic analyses.";
RL   ISME J. 1:703-713(2007).
CC   -!- FUNCTION: Involved in light-induced Na(+)-dependent proton extrusion.
CC       Also seems to be involved in CO(2) transport. {ECO:0000255|HAMAP-
CC       Rule:MF_01308}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01308}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01308}.
CC   -!- SIMILARITY: Belongs to the Cema family. {ECO:0000305}.
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DR   EMBL; CP000239; ABD00679.1; -; Genomic_DNA.
DR   RefSeq; WP_011431352.1; NC_007775.1.
DR   AlphaFoldDB; Q2JRR7; -.
DR   SMR; Q2JRR7; -.
DR   STRING; 321327.CYA_2560; -.
DR   EnsemblBacteria; ABD00679; ABD00679; CYA_2560.
DR   KEGG; cya:CYA_2560; -.
DR   eggNOG; ENOG502Z8DN; Bacteria.
DR   HOGENOM; CLU_690401_0_0_3; -.
DR   OMA; PANRDFI; -.
DR   OrthoDB; 1605855at2; -.
DR   Proteomes; UP000008818; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015078; F:proton transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01308; CemA; 1.
DR   InterPro; IPR004282; CemA.
DR   PANTHER; PTHR33650; PTHR33650; 1.
DR   Pfam; PF03040; CemA; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Hydrogen ion transport; Ion transport;
KW   Membrane; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..460
FT                   /note="Proton extrusion protein PcxA"
FT                   /id="PRO_0000293503"
FT   TRANSMEM        242..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        337..357
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        373..393
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        420..440
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   REGION          84..194
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        84..98
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        106..133
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        164..194
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   460 AA;  52203 MW;  B7D34D4CEAA5844C CRC64;
     MGESVLSRLG QWISSTPLRS LDRAYEAALR IKAIEDRYFQ GGSIGSNGNH GQNTSRYFQI
     QLRQELRQID LSLAEFRASS VFSRLPDPEQ NGSGPPFSSD KDQAKEAPVG PSENDGKDAE
     NGRQSRDPSI LEKLEFIDQV TSRYKRPAAQ PRSTSPPPKS QEQPEPLTSS QPEPSDPSIK
     TNLAKTNLDN SNAPVASKTA LLPRSILRTA NQIRRELSSQ AEEELLQEYR SQRTRTLVAV
     RFLLLLAILP LLVQIFSKHF LFGPLVDRFQ PREPTILALS YEFQEKALSE FEFFKEKIEF
     ERALHHQSPE LDLESEDQLS KKAEELLQKY SRKNLEGLKN VLADVLSLLV FGWLILIGRE
     EIEVLKSFLD RLIYGLSDSA KAFIIILFTD VFVGYHSPHG WEVLLSSLAA HLGLPENRNF
     IYGFIATFPV FLDTLFKYWI FRYLNRVSPS AVATYHAMND