ASPM_FELCA
ID ASPM_FELCA Reviewed; 3461 AA.
AC P62288;
DT 05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Abnormal spindle-like microcephaly-associated protein homolog;
DE Flags: Fragment;
GN Name=ASPM;
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=14722158; DOI=10.1093/hmg/ddh055;
RA Evans P.D., Anderson J.R., Vallender E.J., Gilbert S.L., Malcom C.M.,
RA Dorus S., Lahn B.T.;
RT "Adaptive evolution of ASPM, a major determinant of cerebral cortical size
RT in humans.";
RL Hum. Mol. Genet. 13:489-494(2004).
CC -!- FUNCTION: Probable role in mitotic spindle regulation and coordination
CC of mitotic processes. May have a preferential role in regulating
CC neurogenesis (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton,
CC spindle {ECO:0000250}. Nucleus {ECO:0000250}. Note=The nuclear-
CC cytoplasmic distribution could be regulated by the availability of
CC calmodulin. Localizes to spindle poles during mitosis (By similarity).
CC {ECO:0000250}.
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DR EMBL; AY485420; AAR98741.1; -; mRNA.
DR STRING; 9685.ENSFCAP00000023229; -.
DR PRIDE; P62288; -.
DR eggNOG; KOG0165; Eukaryota.
DR InParanoid; P62288; -.
DR Proteomes; UP000011712; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000922; C:spindle pole; IBA:GO_Central.
DR GO; GO:0005516; F:calmodulin binding; IBA:GO_Central.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0051295; P:establishment of meiotic spindle localization; IBA:GO_Central.
DR GO; GO:0000278; P:mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0007051; P:spindle organization; IBA:GO_Central.
DR Gene3D; 1.10.418.10; -; 2.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR031549; ASH.
DR InterPro; IPR029955; ASPM.
DR InterPro; IPR001715; CH-domain.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR22590:SF4; PTHR22590:SF4; 6.
DR Pfam; PF15780; ASH; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00612; IQ; 38.
DR SMART; SM00033; CH; 2.
DR SMART; SM00015; IQ; 66.
DR SUPFAM; SSF47576; SSF47576; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR SUPFAM; SSF52540; SSF52540; 16.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50096; IQ; 42.
PE 2: Evidence at transcript level;
KW Calmodulin-binding; Cell cycle; Cell division; Coiled coil; Cytoplasm;
KW Cytoskeleton; Mitosis; Nucleus; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..>3461
FT /note="Abnormal spindle-like microcephaly-associated
FT protein homolog"
FT /id="PRO_0000191330"
FT DOMAIN 921..1057
FT /note="Calponin-homology (CH) 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT DOMAIN 1111..1262
FT /note="Calponin-homology (CH) 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT DOMAIN 1267..1296
FT /note="IQ 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1348..1379
FT /note="IQ 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1488..1517
FT /note="IQ 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1511..1540
FT /note="IQ 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1538..1569
FT /note="IQ 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1583..1614
FT /note="IQ 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1633..1662
FT /note="IQ 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1656..1685
FT /note="IQ 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1729..1758
FT /note="IQ 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1752..1783
FT /note="IQ 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1775..1804
FT /note="IQ 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1802..1831
FT /note="IQ 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1825..1854
FT /note="IQ 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1875..1904
FT /note="IQ 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1898..1929
FT /note="IQ 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1948..1979
FT /note="IQ 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1971..2002
FT /note="IQ 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2021..2050
FT /note="IQ 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2044..2075
FT /note="IQ 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2094..2125
FT /note="IQ 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2117..2148
FT /note="IQ 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2167..2198
FT /note="IQ 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2190..2219
FT /note="IQ 23"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2240..2271
FT /note="IQ 24"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2313..2344
FT /note="IQ 25"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2336..2367
FT /note="IQ 26"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2386..2417
FT /note="IQ 27"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2409..2440
FT /note="IQ 28"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2459..2490
FT /note="IQ 29"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2532..2563
FT /note="IQ 30"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2666..2697
FT /note="IQ 31"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2689..2720
FT /note="IQ 32"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2739..2768
FT /note="IQ 33"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2837..2866
FT /note="IQ 34"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2860..2891
FT /note="IQ 35"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2910..2939
FT /note="IQ 36"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2933..2964
FT /note="IQ 37"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2955..2986
FT /note="IQ 38"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 3030..3059
FT /note="IQ 39"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 3080..3111
FT /note="IQ 40"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 3182..3211
FT /note="IQ 41"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 3205..3236
FT /note="IQ 42"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1058..1077
FT /evidence="ECO:0000255"
FT COMPBIAS 10..24
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 279
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 282
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 367
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 392
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 426
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 606
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 1104
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT NON_TER 3461
SQ SEQUENCE 3461 AA; 406398 MW; 408860B1D5CB1BEF CRC64;
MATRRAGRSW EVSPTERRPS ARPRNSAAEE AAASPPVLSL SHFCRSPFLC FGDVRLGASR
TLPLALDNPN EEVAEVKIAH FPAAEQGFSI SPRSFELQPK EKIIISVNWT PLKEGRVREI
VTFLVNDILK HQAILLGNAE EKKKKKRSLW DTINKKKMST SSSDKRNSYI QNVNTTFCVS
QKADRVRSPL QACENLAMKE GCFLTENNSL SLEENKIPIS PISPIFKECH GETSLPLSVR
RSTTYTSLHA CENGELLKVE GADGSEDFNF NEKVTSETSF SSIHNMSGQI EENSKLILTP
TCCSTLNITQ SQGNFLSPDS FVNNSHAANN EPEVATCLSL DTFRKDNSSP VHLESKTVHK
TYRTILSPDS FINDNYGLNQ DLEPESINPI LSPNQFVKDN MAYICISQQT CKLSSLSNKN
SQVSQSPQDQ RTNGVLPCFR ECQGSQSPEA IFEESRTLEM KSDCYSFTKN QPKFPVIQNI
SSYSHDKRTR RPILSATVTK SKSICSRENQ TEANKPKAKR CLNSVAGEFE KPTDTQNEKS
GFQSCLPVID PVFSKSKSYK NAVIPSSKTA LVARKRKSEG NKEDANVRVT VTEHTEVREI
KRIHFSPVES KMATVKKTKK MITPISKHIS YREKSNLRKK TDSLVYRTPH SKTNKRTKPV
VAVAQSTLTF IKPLKTDIPR HPMPFAAKNM FYDERWKEKQ EQGFTWWLNF ILTPDDFTVK
TNISEVNAAT LLLGVESQHK ISVARAPTKD EMSLRAYTAR CRLNRLRRAA CRLFTSENMV
KAIKKLEIEI EARRLIVRKD RHLWKDVGER QKVLNWLLSY NPLWLRIGLE TIYGELISLE
DNSDVTGLAV FILNRLLWNP DIAAEYRHPS VPHLYRDGHE EALSKFTLKK LLLLVCFLDY
AKISRLIDHD PCLFCKDAEF KTSKEILLAF SRDFLSGEGD LSRHLSFLGL PVNHVQTPFD
EFDFAVTNLA VDLQCGVRLV RIMELLTRDW NLSKKLRIPA ISRLQKMHNV DIVLQILRSR
GIQLNDEHGN AILSKDIVDR HREKTLTLLW KIAFAFQVDI SLNLDQLKEE IDFLKHTQSL
KKTTSALSCH SDAIINKEKD KRNSGSFERY SESIKLLMDW VNAVCAFYNK KVENFTVSFS
DGRVLCYLIH HYHPYYVPFD AICQRTTQTV ECTQTGSVVL NSSSESDGSS LDLSLKALDH
ENTSELYKEL LENEKRNFQL VRSAVRDLGG IPAMIHHSDM SNTIPDEKVV ITYLSFLCAR
LLDLCKETRA ARLIQTTWRK YKQKTDLKRH QERDKAARII QSAVISFLSK QRLKKEINAA
LAIQKHWRRL LAQRKLLMLK KEKLEKVQNK SALVIQRYWR RYSTRKQFLK LKYYSVILQS
RIRMILAVTS YKRYLWATVT IQRHWLAYLR RKRDQQRYEM LKSSCLIIQS VFRRWKQHKM
RLQIKATIIL QRAFREWHVR KRAKEEKSAV VIQSWYRMHK ELRKYIHLRS CVVIIQTRFR
CLQAQKSYKR RREAILTIQK FYRAHLKGKT ERANYLQKRA AAIQLQAAFR GMKARNLHRQ
IRAACVFQSY WRMRRDRFRF LNLKKITIKL QAQVRMHQQL QKYKKIKKAA LIIQIHLRAS
VLAKRALASY QKTRSAVIVL QSAYRGMQAR RKFIHILTSI IKIQSYYRAY ISRKKFLRLK
HATVKLQSIV KMKQTRKQYL HLRAATLFIQ QWYRSIKVAA LKREEYVQMR ESCIKLQAFV
RGHLVRKQMR SQRKAAVSLQ SYFRMRKMRQ HYLEMYKAAV VIQNYYRAYK AQVSQRKNFL
QVKRAVTCVQ AAYRGYKVRQ LIKQQSIAAL KIQTAFRGYS KRKKYQYVLQ STIKIQTWYR
TYRTVRDVRM QFLKTKAAVI SLQSAYRGWK VRTQIRRELQ AAVRIQSAFR MAQTQKQFRL
FKTAALVIQQ HLRAWSAGKK QRMEYTELRN AALMLQSTWK GKIVRRQIRK QHKCAVIIQS
YYRMHVQQKK WDIMKKAARL IQMYYRAYRI GRRQRQLYLK TKAAIVIIQS AYRSMRVRKK
IKEYNKAAVA IQSTYRAYKA KKNYATYRAS AVLIQRWYRN IKIANRQRKE YLNLKKTAVK
IQAVFRGIRV RRRIQHMHTA ATFIKAMFKM HQAKVRYHKM RTAAVLIQVR YRAYCQGKIQ
RAKYLTILKA VTVLQASFRG VRVRQTLRKM QNAAIRIQSC YRRYRQQTYF NKLKKVTQTV
QQRYRAVKER NVQFQRYNKL RHSAICIQAG FRGMKARRHL RMMHLAATLI QRRFRTLKMR
RRFLSLRKTA LWVQRKYRAT VCAKHHLQQF LRLQKAVITL QSSYRGWVVR KKMQEMHRAA
TVIQAAFRMH RAHVRYQAVR QASVVIQQRH QANRAAKLQR QRYLRQRHSA LILQAAFRSM
KARRHLKMMH SSAVLIQSRF RGLVVRKRFV SLKKAAVFVQ RRYRATTCAR RHLHQFLKVQ
KAVITIQSSY RRLMAKKKVQ AMHRAAALIQ ATYKMHRTYV TFQAWKHASI LIQQHYRIYR
AAKLQRENYV RQRHSALVIQ AAYKGMKARQ LLREKHRAAI IIQSTYRMYR QYLFYRKIQW
ATKVIQKIYR AKKRKALQHD ALRKVAACVQ ADFQDMIIRK QIQEQHQAAT VLQKHLKASK
VRKHYLHFRA KVVFVQRRYR ALSAVRTQAV ICIQSSYRGF KVRKGIQRMH LAATLIQSLY
RMHRAKLDYR AKKTAVVLIQ YYYRSYVRVK TERKNFLALQ KSVRIIQAAF RGMKVRQKLK
NLSEAKMAAI EKRSAFCRHR TETPYEAVQS SALRIQKWHR ASLVACSQEA ECHSQGRAAV
TIQKAFCKTA TEILETQKHA ALRIQSFLQM AVYRRRFVQQ KRAAVTLQQY FRTWQARKQF
LLYRKAASVL QNHHRGFLSA KPQREAYLHV RSSVIIIQAR TRGFIQKRKF QKIKDSTIKI
QAAWRSYKAR KYLCKVKAAC KIQAWYRSWK ARKEYLAILK AVKVIQGCFY TKLERTRFLN
MRASTIIIQR KWRAMLSGRI AHEHFLMIKR HQAACLIQAN FRRYKGRQVF LRQKSAALTI
QRYIRARKAG KCERIKYVEL KKSTVVLQAL VRGWLVRKRI SEQRTKIRLL HFTAAAYCHL
SALRIQRAYK LHMVMKNAKK QVNSVICVQR WFRTRLQQKR FAQKCHSVIK SQRELQEHMS
QQNRAASVIQ KAVRRFLLRK KKEKINNGIT KIQALWRGYS WRKKNDGTKI KAIRLSLQLV
NREIREENKL YKRTALALHC LLTYKHLSAI LEALKHLEVV TRLSPLCCEN MAQSGAVSKI
FVLIRSCNRS VPCMEVIRYS VQVLLNVAKY EKTTAAVYHV ENCIDTLLDL LQMYREKPGD
KVADKGGSIF TKTCCLLAIL LKTTNRASDV RSRSKVVDRI YSLYKLTARK HKMNTERILY
TQKKNSSISI PFIPETPIRT RIVSRLKPDW VLRRDNMEEI T
