ID   PCXA_SYNJB              Reviewed;         460 AA.
AC   Q2JN84;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Proton extrusion protein PcxA {ECO:0000255|HAMAP-Rule:MF_01308};
GN   Name=pcxA {ECO:0000255|HAMAP-Rule:MF_01308}; OrderedLocusNames=CYB_0810;
OS   Synechococcus sp. (strain JA-2-3B'a(2-13)) (Cyanobacteria bacterium
OS   Yellowstone B-Prime).
OC   Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus;
OC   unclassified Synechococcus.
OX   NCBI_TaxID=321332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JA-2-3B'a(2-13);
RX   PubMed=18059494; DOI=10.1038/ismej.2007.46;
RA   Bhaya D., Grossman A.R., Steunou A.-S., Khuri N., Cohan F.M., Hamamura N.,
RA   Melendrez M.C., Bateson M.M., Ward D.M., Heidelberg J.F.;
RT   "Population level functional diversity in a microbial community revealed by
RT   comparative genomic and metagenomic analyses.";
RL   ISME J. 1:703-713(2007).
CC   -!- FUNCTION: Involved in light-induced Na(+)-dependent proton extrusion.
CC       Also seems to be involved in CO(2) transport. {ECO:0000255|HAMAP-
CC       Rule:MF_01308}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01308}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01308}.
CC   -!- SIMILARITY: Belongs to the Cema family. {ECO:0000305}.
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DR   EMBL; CP000240; ABD01791.1; -; Genomic_DNA.
DR   RefSeq; WP_011432448.1; NC_007776.1.
DR   AlphaFoldDB; Q2JN84; -.
DR   STRING; 321332.CYB_0810; -.
DR   KEGG; cyb:CYB_0810; -.
DR   eggNOG; ENOG502Z8DN; Bacteria.
DR   HOGENOM; CLU_690401_0_0_3; -.
DR   OMA; PANRDFI; -.
DR   OrthoDB; 1605855at2; -.
DR   Proteomes; UP000001938; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015078; F:proton transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01308; CemA; 1.
DR   InterPro; IPR004282; CemA.
DR   PANTHER; PTHR33650; PTHR33650; 1.
DR   Pfam; PF03040; CemA; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Hydrogen ion transport; Ion transport;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..460
FT                   /note="Proton extrusion protein PcxA"
FT                   /id="PRO_0000293502"
FT   TRANSMEM        242..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        337..357
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        373..393
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        420..440
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   REGION          82..128
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          143..190
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        84..119
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        147..187
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   460 AA;  52064 MW;  00B9C90435EC1C4D CRC64;
     MGESVLSRLG QWISNTPLRS LDQAYEAALR IKAIEDQYFQ GGSIGSNGQH GQNVSRYFQI
     QLRRQLRQID LRLAEFRASS AFSRLPDPEQ NGSGPTSAQD KAQQLHAAEA NVSESSSENS
     ENGRQRRDLS ILEKLQFIDQ VTSRYKRPTR KSQPISASIS TSPEPLERPE QPTSTQPSSS
     NVSVKAGSGN GAAPVASKAA ILPRSILRTA SQIRRELSSQ AEEELIQEYR EARTRTLVSI
     RFLLLLAILP LLTQILSKNF LFGPLVDHLQ QREPAIVALS HEFQEKALTE FEFFKERMEF
     ERALHHQSPE WDLESADQLS MKAEELLKKY SRRNSEGLKN ILADLLSLLV FGWLIFVGRE
     EIEVLKSFLD RLIYGLSDSA KAFIIILFTD VFVGYHSPHG WEVLLGNLAA HLGVPENRDF
     IYGFIATFPV FLDTLFKYWI FRYLNRVSPS SVATYRAMND