ID   PCXA_SYNP2              Reviewed;         429 AA.
AC   B1XN58;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Proton extrusion protein PcxA {ECO:0000255|HAMAP-Rule:MF_01308};
GN   Name=pcxA {ECO:0000255|HAMAP-Rule:MF_01308};
GN   OrderedLocusNames=SYNPCC7002_A2799;
OS   Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum
OS   quadruplicatum).
OC   Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus;
OC   unclassified Synechococcus.
OX   NCBI_TaxID=32049;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27264 / PCC 7002 / PR-6;
RA   Li T., Zhao J., Zhao C., Liu Z., Zhao F., Marquardt J., Nomura C.T.,
RA   Persson S., Detter J.C., Richardson P.M., Lanz C., Schuster S.C., Wang J.,
RA   Li S., Huang X., Cai T., Yu Z., Luo J., Zhao J., Bryant D.A.;
RT   "Complete sequence of Synechococcus sp. PCC 7002.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in light-induced Na(+)-dependent proton extrusion.
CC       Also seems to be involved in CO(2) transport. {ECO:0000255|HAMAP-
CC       Rule:MF_01308}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01308}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01308}.
CC   -!- SIMILARITY: Belongs to the Cema family. {ECO:0000305}.
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DR   EMBL; CP000951; ACB00768.1; -; Genomic_DNA.
DR   RefSeq; WP_012308386.1; NC_010475.1.
DR   AlphaFoldDB; B1XN58; -.
DR   STRING; 32049.SYNPCC7002_A2799; -.
DR   PRIDE; B1XN58; -.
DR   EnsemblBacteria; ACB00768; ACB00768; SYNPCC7002_A2799.
DR   KEGG; syp:SYNPCC7002_A2799; -.
DR   eggNOG; ENOG502Z8DN; Bacteria.
DR   HOGENOM; CLU_690401_0_0_3; -.
DR   OMA; PANRDFI; -.
DR   Proteomes; UP000001688; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015078; F:proton transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01308; CemA; 1.
DR   InterPro; IPR004282; CemA.
DR   PANTHER; PTHR33650; PTHR33650; 1.
DR   Pfam; PF03040; CemA; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Hydrogen ion transport; Ion transport;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..429
FT                   /note="Proton extrusion protein PcxA"
FT                   /id="PRO_0000346537"
FT   TRANSMEM        211..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        306..326
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        353..373
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        389..409
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   REGION          139..161
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   429 AA;  49172 MW;  321A786F4DE7F0DE CRC64;
     MNLSTFIKKA RRWFYDTPDR ALEQAYRAAL NIQAIELEHF GGKPVSGHNA DYSDSVIRYF
     QGEVRKQLKI IEVRLREFRS FNTVVPVSEE TIQKKASNIY YPDAADKPTL IIEKLRFIDE
     ITGRYGRGLS KQSVALVPLN GPEAPQTNGD RPDNKPKVET VSDKTGLVPR SIMRTFSRIQ
     REIDPKSNEA EAEVVTKFRR SRNKTAVSIR FLLTLVIVPL LVHQLAKIAI TPFVEEHFFT
     EASPALFVNS DLENEAFEEL EHYRATLEMR QLVGLAPALT EVEITEKIQE KATEIAQDYR
     AESYNAYENI FSDIFSFFAF VGILLISKRE IAMLKGFLDE IVYGLSDSAK AFLIILFTDI
     FVGYHSPHGW EIILENVAKH FGIAESRDFN FLFIATFPVI LDTVLKYWIF RYLNRISPSA
     VATYRNMNE