ID   PCXA_SYNP6              Reviewed;         421 AA.
AC   Q5N4M6;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Proton extrusion protein PcxA {ECO:0000255|HAMAP-Rule:MF_01308};
GN   Name=pcxA {ECO:0000255|HAMAP-Rule:MF_01308}; OrderedLocusNames=syc0553_d;
OS   Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis
OS   nidulans).
OC   Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus.
OX   NCBI_TaxID=269084;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27144 / PCC 6301 / SAUG 1402/1;
RX   PubMed=17211581; DOI=10.1007/s11120-006-9122-4;
RA   Sugita C., Ogata K., Shikata M., Jikuya H., Takano J., Furumichi M.,
RA   Kanehisa M., Omata T., Sugiura M., Sugita M.;
RT   "Complete nucleotide sequence of the freshwater unicellular cyanobacterium
RT   Synechococcus elongatus PCC 6301 chromosome: gene content and
RT   organization.";
RL   Photosyn. Res. 93:55-67(2007).
CC   -!- FUNCTION: Involved in light-induced Na(+)-dependent proton extrusion.
CC       Also seems to be involved in CO(2) transport. {ECO:0000255|HAMAP-
CC       Rule:MF_01308}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01308}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01308}.
CC   -!- SIMILARITY: Belongs to the Cema family. {ECO:0000305}.
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DR   EMBL; AP008231; BAD78743.1; -; Genomic_DNA.
DR   RefSeq; WP_011242865.1; NC_006576.1.
DR   AlphaFoldDB; Q5N4M6; -.
DR   SMR; Q5N4M6; -.
DR   STRING; 269084.syc0553_d; -.
DR   EnsemblBacteria; BAD78743; BAD78743; syc0553_d.
DR   KEGG; syc:syc0553_d; -.
DR   eggNOG; ENOG502Z8DN; Bacteria.
DR   OMA; HSPEGWT; -.
DR   Proteomes; UP000001175; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015078; F:proton transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01308; CemA; 1.
DR   InterPro; IPR004282; CemA.
DR   PANTHER; PTHR33650; PTHR33650; 1.
DR   Pfam; PF03040; CemA; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Hydrogen ion transport; Ion transport;
KW   Membrane; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..421
FT                   /note="Proton extrusion protein PcxA"
FT                   /id="PRO_0000293498"
FT   TRANSMEM        203..223
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        298..318
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        345..365
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        381..401
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   REGION          124..153
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        124..145
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   421 AA;  48390 MW;  8CA79FAB46D19BDE CRC64;
     MAFFAGISDW VAQRLQRNSE TARLDLERAY EAALYITALE TEYASGRSLR RLPSQLSARQ
     QTSLQAELRQ TLRSLRHYRQ RYRRHQPVQL QAGLALGRPG MGMPTIAHEK LQLIEQVLAR
     YGQPTVHSSN PDDSQLMTSK NNSKPVPDPE SDDEYLISQT SFLPRSIFGA FADLRQQLDP
     KAEDQIVQNF RSRKGKTLIA LRFVLLLVLV PLLTQQISKS FIVGPIVDRL RSQDPEAIFL
     NFQMEEEAFV KLNQYQQLLR FQHYLKEAPP LTEAEIDERV REKAEEIAVE YRQESSNAIK
     NIFADLISAA AFAILLISSQ EEIQLLKSFI DEVVYGISDS AKAFIIILFT DIFVGFHSPH
     GWEVILESIS RHFGIPENRS FIFLFIATFP VILDTIFKYW IFRYLNRISP SAVATYRNMN
     E