ID   PCXA_SYNPW              Reviewed;         382 AA.
AC   A5GKT4;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Proton extrusion protein PcxA {ECO:0000255|HAMAP-Rule:MF_01308};
GN   Name=pcxA {ECO:0000255|HAMAP-Rule:MF_01308};
GN   OrderedLocusNames=SynWH7803_1123;
OS   Synechococcus sp. (strain WH7803).
OC   Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus;
OC   unclassified Synechococcus.
OX   NCBI_TaxID=32051;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WH7803;
RG   Genoscope;
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in light-induced Na(+)-dependent proton extrusion.
CC       Also seems to be involved in CO(2) transport. {ECO:0000255|HAMAP-
CC       Rule:MF_01308}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01308}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01308}.
CC   -!- SIMILARITY: Belongs to the Cema family. {ECO:0000305}.
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DR   EMBL; CT971583; CAK23549.1; -; Genomic_DNA.
DR   RefSeq; WP_011933031.1; NC_009481.1.
DR   AlphaFoldDB; A5GKT4; -.
DR   STRING; 32051.SynWH7803_1123; -.
DR   EnsemblBacteria; CAK23549; CAK23549; SynWH7803_1123.
DR   KEGG; syx:SynWH7803_1123; -.
DR   eggNOG; ENOG502Z8DN; Bacteria.
DR   HOGENOM; CLU_690401_0_0_3; -.
DR   OMA; HSPEGWT; -.
DR   OrthoDB; 1605855at2; -.
DR   Proteomes; UP000001566; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015078; F:proton transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01308; CemA; 1.
DR   InterPro; IPR004282; CemA.
DR   PANTHER; PTHR33650; PTHR33650; 1.
DR   Pfam; PF03040; CemA; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Hydrogen ion transport; Ion transport;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..382
FT                   /note="Proton extrusion protein PcxA"
FT                   /id="PRO_1000051818"
FT   TRANSMEM        156..176
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        257..277
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        305..325
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        340..360
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
SQ   SEQUENCE   382 AA;  42881 MW;  CFB23BF1AFE07241 CRC64;
     MAGRNWLDTF GRAKSLDVNA DLDRGYEAAL LIQSLELEYY GDRPIRPDLE LSVPSSVQAT
     VLRKFRAAIS VCRASLDKLE YQRGELDPQE LRQLQLIESV VNRYSPRRTA SAPTISRSPD
     PLPRSLLGIF DTLRRQLNPT AEATLVAGFR RRRDSTLISL KVLLLLILVP LLVQQVSRTY
     IISPAVDRYA PDLPFLSYPK PQLEEQAVEK LRVYKAEIEF DALLRGDSIP TQEELQKKLS
     AKAEELKQEA DSESTHAVKN VIADLAATVA FVVVCVFSRE ELRVLRGFFD EAVYGLSDSA
     KAFAIILFTD IFVGFHSPEG WTVLLDGIAN HFGFPARENF ILLFIATFPV ILATIFKYWI
     FRYLNRVSPS SVATLRGMNG GG