ID   PCXA_SYNR3              Reviewed;         379 AA.
AC   A5GTC7;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Proton extrusion protein PcxA {ECO:0000255|HAMAP-Rule:MF_01308};
GN   Name=pcxA {ECO:0000255|HAMAP-Rule:MF_01308};
GN   OrderedLocusNames=SynRCC307_1233;
OS   Synechococcus sp. (strain RCC307).
OC   Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus;
OC   unclassified Synechococcus.
OX   NCBI_TaxID=316278;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RCC307;
RG   Genoscope;
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in light-induced Na(+)-dependent proton extrusion.
CC       Also seems to be involved in CO(2) transport. {ECO:0000255|HAMAP-
CC       Rule:MF_01308}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01308}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01308}.
CC   -!- SIMILARITY: Belongs to the Cema family. {ECO:0000305}.
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DR   EMBL; CT978603; CAK28136.1; -; Genomic_DNA.
DR   RefSeq; WP_011935650.1; NC_009482.1.
DR   AlphaFoldDB; A5GTC7; -.
DR   STRING; 316278.SynRCC307_1233; -.
DR   EnsemblBacteria; CAK28136; CAK28136; SynRCC307_1233.
DR   KEGG; syr:SynRCC307_1233; -.
DR   eggNOG; ENOG502Z8DN; Bacteria.
DR   HOGENOM; CLU_690401_0_0_3; -.
DR   OMA; HSPEGWT; -.
DR   OrthoDB; 1605855at2; -.
DR   Proteomes; UP000001115; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015078; F:proton transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01308; CemA; 1.
DR   InterPro; IPR004282; CemA.
DR   PANTHER; PTHR33650; PTHR33650; 1.
DR   Pfam; PF03040; CemA; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Hydrogen ion transport; Ion transport;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..379
FT                   /note="Proton extrusion protein PcxA"
FT                   /id="PRO_1000051819"
FT   TRANSMEM        153..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        254..274
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        300..320
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        337..357
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
SQ   SEQUENCE   379 AA;  42746 MW;  54D6503F8DD20735 CRC64;
     MGLNDWLGTF AKAEGLDLSS DLEQAYEAAL MIQGLELEYF NDRPVRTDVN LGLPQATQTQ
     IFRRFRSALE ICRALLSSIE RQRAQLDSQE LRQLQLIESV VRRYRSKDGQ TLFQRPDPLP
     RSLLGVFDRV RNQLDPEAEA NVVAGFRRRR DSTLVSLRIL LLMILVPLLL QQISRTYVIS
     PLVDRIAPDI PFLSYTKPRL QQSAVASLRE YKAEIEFAAL LEGEDSPSVE ELRQKLTLKA
     AELKDEADSE STTAIKNVLA DVVATIGFVL VCLFGRDEIR VLRGFFDEVV YGLSDNAKAF
     VIILFTDIFV GFHSPEGWTV LLQGISSHLG IPAEEQFIDL FIATFPVILA TIFKYWIFRY
     LNRVSPSSVT TLRGMNGGG