ID   PCXA_SYNS3              Reviewed;         382 AA.
AC   Q0IAI7;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Proton extrusion protein PcxA {ECO:0000255|HAMAP-Rule:MF_01308};
GN   Name=pcxA {ECO:0000255|HAMAP-Rule:MF_01308}; OrderedLocusNames=sync_1328;
OS   Synechococcus sp. (strain CC9311).
OC   Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus;
OC   unclassified Synechococcus.
OX   NCBI_TaxID=64471;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CC9311;
RX   PubMed=16938853; DOI=10.1073/pnas.0602963103;
RA   Palenik B., Ren Q., Dupont C.L., Myers G.S., Heidelberg J.F., Badger J.H.,
RA   Madupu R., Nelson W.C., Brinkac L.M., Dodson R.J., Durkin A.S.,
RA   Daugherty S.C., Sullivan S.A., Khouri H., Mohamoud Y., Halpin R.,
RA   Paulsen I.T.;
RT   "Genome sequence of Synechococcus CC9311: insights into adaptation to a
RT   coastal environment.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:13555-13559(2006).
CC   -!- FUNCTION: Involved in light-induced Na(+)-dependent proton extrusion.
CC       Also seems to be involved in CO(2) transport. {ECO:0000255|HAMAP-
CC       Rule:MF_01308}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01308}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01308}.
CC   -!- SIMILARITY: Belongs to the Cema family. {ECO:0000305}.
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DR   EMBL; CP000435; ABI46296.1; -; Genomic_DNA.
DR   RefSeq; WP_011619255.1; NC_008319.1.
DR   AlphaFoldDB; Q0IAI7; -.
DR   SMR; Q0IAI7; -.
DR   STRING; 64471.sync_1328; -.
DR   PRIDE; Q0IAI7; -.
DR   EnsemblBacteria; ABI46296; ABI46296; sync_1328.
DR   KEGG; syg:sync_1328; -.
DR   eggNOG; ENOG502Z8DN; Bacteria.
DR   HOGENOM; CLU_690401_0_0_3; -.
DR   OMA; HSPEGWT; -.
DR   OrthoDB; 1605855at2; -.
DR   Proteomes; UP000001961; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015078; F:proton transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01308; CemA; 1.
DR   InterPro; IPR004282; CemA.
DR   PANTHER; PTHR33650; PTHR33650; 1.
DR   Pfam; PF03040; CemA; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Hydrogen ion transport; Ion transport;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..382
FT                   /note="Proton extrusion protein PcxA"
FT                   /id="PRO_0000293499"
FT   TRANSMEM        156..176
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        257..277
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        305..325
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        340..360
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
SQ   SEQUENCE   382 AA;  42980 MW;  F94D5ED7F3D1FFF8 CRC64;
     MAFRNWIGAF GKANALDVNS DLDRGYEAAL LIQSLELEYY GDRPIRPDLE LSVPKSVQAT
     VLRKFRVAIN VCRASLDQLE YQRSQLDPQE LRQLQLIESV VNRYSPKRVS TAPTMTRDPD
     PLPRSLLGVF DKVRRQLNPA GEATLVAGFR RRRDSTLISL KVLLLLILVP LLVQQVSRTY
     IISPAVDRFA PDLPFLSYPK PQLEEQAVEK LRVYKAEIEF DALLRGDTIP SQEELQQQLG
     KKASELKEEA DAESTHAVKN VLADISATIA FVVVCLFSRE ELRVLRGFFD EAVYGLSDSA
     KAFAIILFTD IFVGFHSPEG WTVLLDGIAN HFGFPARENF ILLFIATFPV ILATIFKYWI
     FRYLNRVSPS SVATLRGMNG GG