ID   PCXA_SYNS9              Reviewed;         383 AA.
AC   Q3AXS7;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Proton extrusion protein PcxA {ECO:0000255|HAMAP-Rule:MF_01308};
GN   Name=pcxA {ECO:0000255|HAMAP-Rule:MF_01308};
GN   OrderedLocusNames=Syncc9902_1145;
OS   Synechococcus sp. (strain CC9902).
OC   Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus;
OC   unclassified Synechococcus.
OX   NCBI_TaxID=316279;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CC9902;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Martinez M., Schmutz J., Larimer F.,
RA   Land M., Kyrpides N., Ivanova N., Richardson P.;
RT   "Complete sequence of Synechococcus sp. CC9902.";
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in light-induced Na(+)-dependent proton extrusion.
CC       Also seems to be involved in CO(2) transport. {ECO:0000255|HAMAP-
CC       Rule:MF_01308}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01308}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01308}.
CC   -!- SIMILARITY: Belongs to the Cema family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000097; ABB26109.1; -; Genomic_DNA.
DR   RefSeq; WP_011359936.1; NC_007513.1.
DR   AlphaFoldDB; Q3AXS7; -.
DR   SMR; Q3AXS7; -.
DR   STRING; 316279.Syncc9902_1145; -.
DR   EnsemblBacteria; ABB26109; ABB26109; Syncc9902_1145.
DR   KEGG; sye:Syncc9902_1145; -.
DR   eggNOG; ENOG502Z8DN; Bacteria.
DR   HOGENOM; CLU_690401_0_0_3; -.
DR   OMA; HSPEGWT; -.
DR   OrthoDB; 1605855at2; -.
DR   Proteomes; UP000002712; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015078; F:proton transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01308; CemA; 1.
DR   InterPro; IPR004282; CemA.
DR   PANTHER; PTHR33650; PTHR33650; 1.
DR   Pfam; PF03040; CemA; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Hydrogen ion transport; Ion transport;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..383
FT                   /note="Proton extrusion protein PcxA"
FT                   /id="PRO_0000293501"
FT   TRANSMEM        163..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        258..278
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        306..326
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        341..361
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
SQ   SEQUENCE   383 AA;  43102 MW;  E28DAF27270B88D4 CRC64;
     MSRRNWVNFF SRGQGFDLTN DLERGYESAL LIQNLELEFY GDRLVRSDVE LGVPKSVQAS
     ILRRFRAALL ICRTTLESVE RNRGQFDLQE LRQLQLIEAV VSRYGYQLPS GGSPAISRAP
     EALPRSLLGF FDTVRRQLDP ASEETVVAGF RRRRNSTLIS LRILLLLILV PLLIQQVAGA
     YIISPAVDRL SPELPFLSYP KPKLEEQAVE KLRVYKQELE FDALLNSDQP LEADQLRQKL
     AEKAIELKDE ADGLSVQAVK NVFSDLSALI AFTVVCFASR DDLRVMRGFF DEAVYGLSDS
     AKAFAIILFT DIFVGFHSPE GWTVLLNGIA KHLGLPSQEN FVMLFIATFP VILATIFKYW
     IFRYLNRVSP SSVATLKGMN GSG