ID   PCXA_SYNSC              Reviewed;         382 AA.
AC   Q3AJZ9;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Proton extrusion protein PcxA {ECO:0000255|HAMAP-Rule:MF_01308};
GN   Name=pcxA {ECO:0000255|HAMAP-Rule:MF_01308};
GN   OrderedLocusNames=Syncc9605_1329;
OS   Synechococcus sp. (strain CC9605).
OC   Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus;
OC   unclassified Synechococcus.
OX   NCBI_TaxID=110662;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CC9605;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Schmutz J., Martinez M., Larimer F.,
RA   Land M., Kyrpides N., Ivanova N., Richardson P.;
RT   "Complete sequence of Synechococcus sp. CC9605.";
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in light-induced Na(+)-dependent proton extrusion.
CC       Also seems to be involved in CO(2) transport. {ECO:0000255|HAMAP-
CC       Rule:MF_01308}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01308}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01308}.
CC   -!- SIMILARITY: Belongs to the Cema family. {ECO:0000305}.
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DR   EMBL; CP000110; ABB35083.1; -; Genomic_DNA.
DR   RefSeq; WP_011364303.1; NC_007516.1.
DR   AlphaFoldDB; Q3AJZ9; -.
DR   SMR; Q3AJZ9; -.
DR   STRING; 110662.Syncc9605_1329; -.
DR   EnsemblBacteria; ABB35083; ABB35083; Syncc9605_1329.
DR   KEGG; syd:Syncc9605_1329; -.
DR   eggNOG; ENOG502Z8DN; Bacteria.
DR   HOGENOM; CLU_690401_0_0_3; -.
DR   OMA; HSPEGWT; -.
DR   OrthoDB; 1605855at2; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015078; F:proton transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01308; CemA; 1.
DR   InterPro; IPR004282; CemA.
DR   PANTHER; PTHR33650; PTHR33650; 1.
DR   Pfam; PF03040; CemA; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Hydrogen ion transport; Ion transport;
KW   Membrane; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..382
FT                   /note="Proton extrusion protein PcxA"
FT                   /id="PRO_0000293500"
FT   TRANSMEM        162..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        257..277
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        305..325
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        340..360
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
SQ   SEQUENCE   382 AA;  42646 MW;  C0D8886FB6A48D81 CRC64;
     MSRRNWINLF STSQSVELSG DLERGYDAAL LIQSLELEYY GDRQIRPELK LSVPRSVQAT
     ILRRFKTALS ICRSSAAKLS DQRGQLDSQE LRQLQLIESI VSRYGSRRST SSPSISRSPD
     ALPRSLLGVF DSIRLQLDPS TEDSVVAGFR RRRDTTLISL RVLLLLVLVP LLVSQISGTY
     LISPAVNQFS PELPFLSYPK PLLEEKAAKK LRLYKQELEF DAFLKGVEPL DDAELRNKLT
     EKATELKHDA DEESLKAIKN VFADLAGLIA FAVVCLMSRD ELRVLRGFVD EAVYGLSDSA
     KAFAIILFTD IFVGYHSPEG WSVLLDGVAD HFGLPSSQSF VNLFIATFPV VLATIFKYWI
     FRYLNRVSPS SVATLKGMNG GG