ID   PCXA_THEVB              Reviewed;         461 AA.
AC   P59112;
DT   06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2002, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Proton extrusion protein PcxA {ECO:0000255|HAMAP-Rule:MF_01308};
GN   Name=pcxA {ECO:0000255|HAMAP-Rule:MF_01308}; OrderedLocusNames=tll0748;
OS   Thermosynechococcus vestitus (strain NIES-2133 / IAM M-273 / BP-1).
OC   Bacteria; Cyanobacteria; Pseudanabaenales; Thermosynechococcaceae;
OC   Thermosynechococcus.
OX   NCBI_TaxID=197221;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIES-2133 / IAM M-273 / BP-1;
RX   PubMed=12240834; DOI=10.1093/dnares/9.4.123;
RA   Nakamura Y., Kaneko T., Sato S., Ikeuchi M., Katoh H., Sasamoto S.,
RA   Watanabe A., Iriguchi M., Kawashima K., Kimura T., Kishida Y., Kiyokawa C.,
RA   Kohara M., Matsumoto M., Matsuno A., Nakazaki N., Shimpo S., Sugimoto M.,
RA   Takeuchi C., Yamada M., Tabata S.;
RT   "Complete genome structure of the thermophilic cyanobacterium
RT   Thermosynechococcus elongatus BP-1.";
RL   DNA Res. 9:123-130(2002).
CC   -!- FUNCTION: Involved in light-induced Na(+)-dependent proton extrusion.
CC       Also seems to be involved in CO(2) transport. {ECO:0000255|HAMAP-
CC       Rule:MF_01308}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01308}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01308}.
CC   -!- SIMILARITY: Belongs to the Cema family. {ECO:0000305}.
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DR   EMBL; BA000039; BAC08299.1; -; Genomic_DNA.
DR   RefSeq; NP_681537.1; NC_004113.1.
DR   RefSeq; WP_011056595.1; NC_004113.1.
DR   AlphaFoldDB; P59112; -.
DR   STRING; 197221.22294469; -.
DR   EnsemblBacteria; BAC08299; BAC08299; BAC08299.
DR   KEGG; tel:tll0748; -.
DR   PATRIC; fig|197221.4.peg.788; -.
DR   eggNOG; ENOG502Z8DN; Bacteria.
DR   OMA; PANRDFI; -.
DR   OrthoDB; 1605855at2; -.
DR   Proteomes; UP000000440; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015078; F:proton transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01308; CemA; 1.
DR   InterPro; IPR004282; CemA.
DR   PANTHER; PTHR33650; PTHR33650; 1.
DR   Pfam; PF03040; CemA; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Hydrogen ion transport; Ion transport;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..461
FT                   /note="Proton extrusion protein PcxA"
FT                   /id="PRO_0000216669"
FT   TRANSMEM        244..264
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        339..359
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        386..406
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        421..441
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
SQ   SEQUENCE   461 AA;  52814 MW;  0F66AC6862A1749D CRC64;
     MSSNPFIGLR NWIRGAQQWY LTTPKRALQE AYEAALKIRA IELEHFDGQP ISPLNLPVGE
     VSSYFETELK QLLKTIRMRM MEFRASRQIL PLAPFQSPPT PVNEGINGAT ETYTVTATVS
     STTAEPSVYE KLRVIDATLN RYKRQREKEL DALARPSLSR QDPQQRQQAA ALDKIAEDSL
     YLSEYISDDL TSDSKLDSSS FIPRSILRTA DRFRRELNSD EATEAEVVRD FRTSKLRTRL
     AVRFMLLLVI LPLLTQQISK ALIVSPLVNH FKAVGQIERI INSQLEDNIL DELARFENKI
     RFESLVSNVP IAPEEIQNRI REKAIELSTE YQKELIEPLK NILSDALGFT VFLALVFTGQ
     RQLAIVKTFL DEVVYGLSDS AKAFMIILFT DVFVGFHSPH GWEVLVNNTL EHFGFPRNED
     FINMFIATFP VMLDTVFKYW IFRYLNQISP SAVATYKNMN E