ASPM_GORGO
ID ASPM_GORGO Reviewed; 3476 AA.
AC P62289;
DT 05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Abnormal spindle-like microcephaly-associated protein homolog;
GN Name=ASPM;
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ARG-1931; ILE-1974;
RP MET-2765 AND ILE-3166.
RX PubMed=14722158; DOI=10.1093/hmg/ddh055;
RA Evans P.D., Anderson J.R., Vallender E.J., Gilbert S.L., Malcom C.M.,
RA Dorus S., Lahn B.T.;
RT "Adaptive evolution of ASPM, a major determinant of cerebral cortical size
RT in humans.";
RL Hum. Mol. Genet. 13:489-494(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND VARIANTS TYR-464; HIS-1712;
RP ARG-1931; ILE-1974; MET-2157; GLU-2758; MET-2765; SER-2989 AND ILE-3166.
RX PubMed=15045028; DOI=10.1371/journal.pbio.0020126;
RA Kouprina N., Pavlicek A., Mochida G.H., Solomon G., Gersch W., Yoon Y.-H.,
RA Collura R., Ruvolo M., Barrett J.C., Woods C.G., Walsh C.A., Jurka J.,
RA Larionov V.;
RT "Accelerated evolution of the ASPM gene controlling brain size begins prior
RT to human brain expansion.";
RL PLoS Biol. 2:653-663(2004).
CC -!- FUNCTION: Probable role in mitotic spindle regulation and coordination
CC of mitotic processes. May have a preferential role in regulating
CC neurogenesis (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton,
CC spindle {ECO:0000250}. Nucleus {ECO:0000250}. Note=The nuclear-
CC cytoplasmic distribution could be regulated by the availability of
CC calmodulin. Localizes to spindle poles during mitosis (By similarity).
CC {ECO:0000250}.
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DR EMBL; AY488938; AAR84352.1; -; Genomic_DNA.
DR EMBL; AY488911; AAR84352.1; JOINED; Genomic_DNA.
DR EMBL; AY488912; AAR84352.1; JOINED; Genomic_DNA.
DR EMBL; AY488913; AAR84352.1; JOINED; Genomic_DNA.
DR EMBL; AY488914; AAR84352.1; JOINED; Genomic_DNA.
DR EMBL; AY488915; AAR84352.1; JOINED; Genomic_DNA.
DR EMBL; AY488916; AAR84352.1; JOINED; Genomic_DNA.
DR EMBL; AY488917; AAR84352.1; JOINED; Genomic_DNA.
DR EMBL; AY488918; AAR84352.1; JOINED; Genomic_DNA.
DR EMBL; AY488919; AAR84352.1; JOINED; Genomic_DNA.
DR EMBL; AY488920; AAR84352.1; JOINED; Genomic_DNA.
DR EMBL; AY488921; AAR84352.1; JOINED; Genomic_DNA.
DR EMBL; AY488922; AAR84352.1; JOINED; Genomic_DNA.
DR EMBL; AY488923; AAR84352.1; JOINED; Genomic_DNA.
DR EMBL; AY488924; AAR84352.1; JOINED; Genomic_DNA.
DR EMBL; AY488925; AAR84352.1; JOINED; Genomic_DNA.
DR EMBL; AY488926; AAR84352.1; JOINED; Genomic_DNA.
DR EMBL; AY488927; AAR84352.1; JOINED; Genomic_DNA.
DR EMBL; AY488928; AAR84352.1; JOINED; Genomic_DNA.
DR EMBL; AY488929; AAR84352.1; JOINED; Genomic_DNA.
DR EMBL; AY488930; AAR84352.1; JOINED; Genomic_DNA.
DR EMBL; AY488931; AAR84352.1; JOINED; Genomic_DNA.
DR EMBL; AY488932; AAR84352.1; JOINED; Genomic_DNA.
DR EMBL; AY488933; AAR84352.1; JOINED; Genomic_DNA.
DR EMBL; AY488934; AAR84352.1; JOINED; Genomic_DNA.
DR EMBL; AY488935; AAR84352.1; JOINED; Genomic_DNA.
DR EMBL; AY488936; AAR84352.1; JOINED; Genomic_DNA.
DR EMBL; AY488937; AAR84352.1; JOINED; Genomic_DNA.
DR EMBL; AY497014; AAS48530.1; -; Genomic_DNA.
DR EMBL; AY508451; AAS45486.1; -; mRNA.
DR RefSeq; NP_001266535.1; NM_001279606.1.
DR STRING; 9593.ENSGGOP00000024559; -.
DR PRIDE; P62289; -.
DR GeneID; 101132110; -.
DR KEGG; ggo:101132110; -.
DR CTD; 259266; -.
DR eggNOG; KOG0165; Eukaryota.
DR InParanoid; P62289; -.
DR Proteomes; UP000001519; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000922; C:spindle pole; IBA:GO_Central.
DR GO; GO:0005516; F:calmodulin binding; IBA:GO_Central.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0051295; P:establishment of meiotic spindle localization; IBA:GO_Central.
DR GO; GO:0000278; P:mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0007051; P:spindle organization; IBA:GO_Central.
DR Gene3D; 1.10.418.10; -; 2.
DR Gene3D; 1.25.10.10; -; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR031549; ASH.
DR InterPro; IPR029955; ASPM.
DR InterPro; IPR001715; CH-domain.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR22590:SF4; PTHR22590:SF4; 6.
DR Pfam; PF15780; ASH; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00612; IQ; 38.
DR SMART; SM00033; CH; 2.
DR SMART; SM00015; IQ; 62.
DR SUPFAM; SSF47576; SSF47576; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR SUPFAM; SSF52540; SSF52540; 19.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50096; IQ; 40.
PE 2: Evidence at transcript level;
KW Calmodulin-binding; Cell cycle; Cell division; Coiled coil; Cytoplasm;
KW Cytoskeleton; Mitosis; Nucleus; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..3476
FT /note="Abnormal spindle-like microcephaly-associated
FT protein homolog"
FT /id="PRO_0000191331"
FT DOMAIN 919..1055
FT /note="Calponin-homology (CH) 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT DOMAIN 1109..1260
FT /note="Calponin-homology (CH) 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT DOMAIN 1346..1377
FT /note="IQ 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1392..1421
FT /note="IQ 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1581..1612
FT /note="IQ 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1604..1633
FT /note="IQ 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1631..1660
FT /note="IQ 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1654..1683
FT /note="IQ 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1727..1756
FT /note="IQ 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1750..1781
FT /note="IQ 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1800..1829
FT /note="IQ 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1823..1852
FT /note="IQ 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1873..1902
FT /note="IQ 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1896..1927
FT /note="IQ 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1946..1977
FT /note="IQ 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1969..2000
FT /note="IQ 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2019..2048
FT /note="IQ 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2042..2073
FT /note="IQ 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2092..2123
FT /note="IQ 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2115..2146
FT /note="IQ 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2165..2196
FT /note="IQ 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2238..2269
FT /note="IQ 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2261..2292
FT /note="IQ 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2310..2341
FT /note="IQ 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2333..2364
FT /note="IQ 23"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2383..2414
FT /note="IQ 24"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2406..2437
FT /note="IQ 25"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2456..2487
FT /note="IQ 26"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2479..2510
FT /note="IQ 27"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2529..2560
FT /note="IQ 28"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2623..2652
FT /note="IQ 29"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2664..2695
FT /note="IQ 30"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2687..2718
FT /note="IQ 31"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2737..2766
FT /note="IQ 32"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2858..2889
FT /note="IQ 33"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2908..2937
FT /note="IQ 34"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2931..2962
FT /note="IQ 35"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2953..2984
FT /note="IQ 36"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 3028..3059
FT /note="IQ 37"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 3078..3109
FT /note="IQ 38"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 3180..3209
FT /note="IQ 39"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 3203..3234
FT /note="IQ 40"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 416..443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 562..581
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1056..1077
FT /evidence="ECO:0000255"
FT MOD_RES 280
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 283
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 367
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 392
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 425
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 604
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 1102
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT VARIANT 464
FT /note="F -> Y"
FT /evidence="ECO:0000269|PubMed:15045028"
FT /id="VAR_019087"
FT VARIANT 1712
FT /note="R -> H"
FT /evidence="ECO:0000269|PubMed:15045028"
FT /id="VAR_019088"
FT VARIANT 1931
FT /note="K -> R"
FT /evidence="ECO:0000269|PubMed:14722158,
FT ECO:0000269|PubMed:15045028"
FT /id="VAR_019089"
FT VARIANT 1974
FT /note="V -> I"
FT /evidence="ECO:0000269|PubMed:14722158,
FT ECO:0000269|PubMed:15045028"
FT /id="VAR_019090"
FT VARIANT 2157
FT /note="T -> M"
FT /evidence="ECO:0000269|PubMed:15045028"
FT /id="VAR_019091"
FT VARIANT 2758
FT /note="K -> E"
FT /evidence="ECO:0000269|PubMed:15045028"
FT /id="VAR_019092"
FT VARIANT 2765
FT /note="V -> M"
FT /evidence="ECO:0000269|PubMed:14722158,
FT ECO:0000269|PubMed:15045028"
FT /id="VAR_019093"
FT VARIANT 2989
FT /note="T -> S"
FT /evidence="ECO:0000269|PubMed:15045028"
FT /id="VAR_019094"
FT VARIANT 3166
FT /note="V -> I"
FT /evidence="ECO:0000269|PubMed:14722158,
FT ECO:0000269|PubMed:15045028"
FT /id="VAR_019095"
FT CONFLICT 213
FT /note="T -> I (in Ref. 2; AAS45486)"
FT /evidence="ECO:0000305"
FT CONFLICT 451
FT /note="F -> V (in Ref. 1; AAR84352)"
FT /evidence="ECO:0000305"
FT CONFLICT 626
FT /note="H -> R (in Ref. 1; AAR84352)"
FT /evidence="ECO:0000305"
FT CONFLICT 1557
FT /note="R -> S (in Ref. 2; AAS45486)"
FT /evidence="ECO:0000305"
FT CONFLICT 1668
FT /note="H -> Y (in Ref. 1; AAR84352)"
FT /evidence="ECO:0000305"
FT CONFLICT 1941..1961
FT /note="MEYIELRHAVLMLQSMWRGKT -> I (in Ref. 2; AAS45486)"
FT /evidence="ECO:0000305"
FT CONFLICT 2125
FT /note="V -> M (in Ref. 1; AAR84352 and 2; AAS45486)"
FT /evidence="ECO:0000305"
FT CONFLICT 2331
FT /note="R -> Q (in Ref. 2; AAS45486)"
FT /evidence="ECO:0000305"
FT CONFLICT 2355
FT /note="T -> A (in Ref. 1; AAR84352 and 2; AAS45486)"
FT /evidence="ECO:0000305"
FT CONFLICT 2451
FT /note="H -> Y (in Ref. 2; AAS45486)"
FT /evidence="ECO:0000305"
FT CONFLICT 2484
FT /note="I -> V (in Ref. 1; AAR84352 and 2; AAS45486)"
FT /evidence="ECO:0000305"
FT CONFLICT 2512
FT /note="H -> L (in Ref. 2; AAS45486)"
FT /evidence="ECO:0000305"
FT CONFLICT 2836
FT /note="K -> R (in Ref. 1; AAR84352)"
FT /evidence="ECO:0000305"
FT CONFLICT 3015
FT /note="S -> P (in Ref. 2; AAS45486)"
FT /evidence="ECO:0000305"
FT CONFLICT 3337
FT /note="D -> E (in Ref. 2; AAS45486)"
FT /evidence="ECO:0000305"
FT CONFLICT 3465
FT /note="I -> L (in Ref. 1; AAR84352 and 2; AAS45486)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 3476 AA; 409558 MW; 3972201FAD535274 CRC64;
MANRRVGRGC WEVSPTERRP PAGLRGPAAE EEASSPPVLS LSHFCRSPFL CFGDVLLGAS
RTLSLALDNP NEEVAEVKIS HFPAADLGFS VSQRCFVLQP KEKIVISVNW TPLKEGRVRE
IMTFLVNDVL KHQAILLGNA EEQKKKKRSL WDTIKKKKIS ASTSHNRRVS NIQNVNKTFS
VSQKVDRVRS PLQACENLAM NEGGPPTENN SLTLEENKIP ISPISPAFNE CHGATCLPLS
VRRSTTYSSL HASENRELLN VHSANVSKVS FNEKAVTETS FNSVNVNGQS GENSKLSLTP
NYSSTLNITQ SQIHFLSPDS FVNNSHGANN ELELVTCLSS DMFMKDNSKP VHLESTIAHE
IYQKILSPDS FIKDNYGLNQ DLESESVNPI LSPNQFLKDN MAYVCTSQQT CKVPLSNENS
QVPQSPEDWR KSEVSPRIPE CQGSKSPKAI FEEIVEMKSN YYSFIKQNNP KFSAVQDISS
HSHNKQPKRR PILSATVTKR KATCTRENQT EINKPKAKRC LNSAVGEHEK VINNQKEKDF
HSYLPIIDPI LSKSKSYKNE VAPSSTTASV ARKRKSDGSM EDANVRVAVT EHTEVREIKR
IHFSPSEPKT SAVKKTKNVI TPISKHISNR EKLNLKKKTD LSIFRTPISK TNKRTKPIIA
VAQSNLTFIK PLKTDIPRHP MPFAAKNMFY DERWKEKQEQ GFTWWLNFIL TPDDFTVKTN
ISEVNAATLL LGIENQHKIS VPRAPTKEEM SLRAYTARCR LNRLRRAACR LFTSEKMVKA
IKKLEIEIEA RRLIVRKDRH LWKDVGERQK VLNWLLSYNP LWLRIGLETT YGELISLEDN
SDVTGLAMFI LNRLLWNPDI AAEYRHPTVP HLYRDGHEEA LSKFTLKKLL LLVCFLDYAK
ISRLIDHDPC LFCKDAEFKA SKEILLAFSR DFLSGEGDLS RHLGLLGLPV NHVQTPFDEF
DFAVTNLAVD LQCGVRLVRT MELLTQNWDL SKKLRIPAIS RLQKMHNVDV VLQVLKSRGI
ELSDEHGNTI LSKDIVDRHR EKTLRLLWKI AFAFQVDISL NLDQLKEEIA FLKHTKSIKK
TISLLSCHSD DLINKKKGKR DSGSFEQYSE NIKLLMDWVN AVCAFYNKKV ENFTVSFSDG
RVLCYLIHHY HPCYVPFDAI CQRTTQTVEC TQTGSVVLNS SSESDDSSLD MSLKAFDHEN
TSELYKELLE NEKKNFHLVR SAVRDLGGIP AMINHSDMSN TIPDEKVVIT YLSFLCARLL
DLRKEIRAAR LIQTTWRKYK LKTDLKRHQE REKAARIIQL AVINFLAKQR LRKRVNAALV
IQKYWRRVLA QRKLLMLKKE KLEKVQNKAA SLIQGYWRRY STRRRFLKLK YYSIILQSRI
RMIIAVTSYK RYLWATVTIQ RHWRAYLRRK QDQQRYEMLK SSTLVIQSMF RKWKQRKMQS
QVKATVILQR AFREWHLRKH AKEENSAIII QSWYRMHKEL QKYIYIRSCV VIIQKRFRCF
QAQKLYKRKK ESILTIQKYY KAYLKGKIER TNYLQKRAAA IQLQAAFRRL KAHNLCRQIR
AACVIQSYWR MRQDRVRFLN LKKTIIKLQA HVRKHQQRQK YKKMKKAAVI IQTHFRAYIF
ARKVLASYQK TRSAVIVLQS AYRGMQARKM YVHILTSVIK IQSYYRAHVS KKEFLSLKNA
TIKLQSIVKM KQTRKQYLHL RAAALFIQQC YRSKKIAAQK REEYMQMRES CIKLQAFVRG
YLVRKQMRLQ RKAVISLQSY FRMRKARQYY LKMYKAIIVI QNYYHAYKAQ VNQRKNFLQV
KKAATCLQAA YRGYKVRQLI KQQSIAALKI QSAFRGYNKR VKYQSVLQSI IKIQRWYRAY
KTLHDTRTHF LKTKAALISL QSAYRGWKVR KQIRREHQAV LKIQSAFRMA KAQKQFRLFK
TAALVIQQNF KAWTAGRKQR MEYIELRHAV LMLQSMWRGK TLRRQLQRQH KCAVIIQSYY
RMHVQQKKWK IMKKAALLIQ KYYRAYSIGR EQNHLYLKTK AAVVTLQSAY RGMKVRKRIK
DCNKAAVTIQ SKYRAYKTKK KYATYRASAI IIQRWYRGIK ITNHQHKEYL NLKKTAIKIQ
SVYRGIRVRR HIQHMHRAAT FIKAVFKMHQ SRISYHTMRK AAIVIQVRFR AYYQGKTQRE
KYLTILKAVK ILQASFRGVR VRRTLRKMQI AATLIQSNYR RYRKQTYFNK LKKITKTVQQ
RYRAMKERNI QFQRYNKLRH SVIYIQAIFR GKKARRHLKM MHIAATLIQR RFRTLMMRRR
FLSLKKTAIL IQRKYRAHLC TKHHLQFLQV QNAVIKIQSS YRRWMIRKRM REMHRAATFI
QATFRMHRLH MRYQTLKQAS VVIQQQYQAN RAAKLQRQHY LRQRHSAVIL QAAFRGMKTR
RHLKSMHSSA TLIQSRFRSL LVRRRFISLK KATIFVQRKY RATICAKHKL HQFLHLRKAA
ITIQSSYRRL MVKKKLQEMQ RAAILIQATF RMHRTYTTFQ TWKHASILIQ QHYRTYRAAK
LQRENYIRQW HSAVVIQAAY KGMKARHLLR EKHKASIIIQ STYRMYRQYC FYQKLQWATK
IIQEKYRANK KKQKAFQHNE LKKETCVQAG FQDMNIKKQI QEQHQAAIII QKHCKAFKIR
KHYLHLRATV VSIQRRYRKL TAVRTQAVIC IQSYYRGFKV RKDIQNMHQA ATLIQSFYRM
HRAKVDYETK KTAIVVIQNY YRLYVRVKTE RKNFLAVQKS VRTIQAAFRG MEVRQKLKNV
SEEKVAAIVN QSALCCYRSK TQYEAVQSEG VMIQEWYKAS GLACSQEAEY HSQSRAAVTI
QKAFCRMATR KLETQKYAAL RIQFFLQMAV YRRRFVQQKR AAITLQHYFR TWQTRKQFLL
YRKAAVVLQN HYRAFLSAKH QRQVYLQIRS SVIIIQARSK GFIQKRKFQE IKNSTIKIQA
MWRRYRAKKY LCKVKAACKI QAWYRCWRAH KEYLAILKAV KIIQGCFYTK LERTRFLNVR
ASAIIIQRKW RAILSAKIAH EHFLMIKRHR AACLIQAHYR GYKGRQVFLR QKSAALIIQK
YIRAREAGKR ERIKYIEFKK STVILQALVR GWLVRKRILE QRAKIRLLHF TAAAYYHLNA
LRIQRAYKLY LAMKHANKQV NSVICIQRWF RARLQEKRFI QKYHSVKKIE HEGQECLSQR
NRAASVIQKA VRHFLLRKKQ EKFTSGIIKI QALWRGYSWR KKNDCTKIKA IRLSLQVVNR
EIREENKLYK RTALALHYLL TYKHLSAILE ALKHLEVVTR LSPLCCENMA HSGAISKIFV
LIRSCNRSVP CMEVIRYAVQ VLLNVSKYEK TTSAVYDVEN CIDILLELLQ IYREKPGNKV
ADKGGSIFTK TCCLLAILLK TTNRASDVRS RSKVVDRIYS LYKLTAHKHK MNTERILYKQ
KKNSSISIPF IPETPVRTRI VSRLKPDWVL RRDNMEEITN PLQAIQMVMD TLGIPY
