ID   PCXA_TRIV2              Reviewed;         467 AA.
AC   Q3MDY0;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2005, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Proton extrusion protein PcxA {ECO:0000255|HAMAP-Rule:MF_01308};
GN   Name=pcxA {ECO:0000255|HAMAP-Rule:MF_01308}; Synonyms=cemA;
GN   OrderedLocusNames=Ava_1182;
OS   Trichormus variabilis (strain ATCC 29413 / PCC 7937) (Anabaena variabilis).
OC   Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Trichormus.
OX   NCBI_TaxID=240292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29413 / PCC 7937;
RX   PubMed=25197444; DOI=10.4056/sigs.3899418;
RA   Thiel T., Pratte B.S., Zhong J., Goodwin L., Copeland A., Lucas S., Han C.,
RA   Pitluck S., Land M.L., Kyrpides N.C., Woyke T.;
RT   "Complete genome sequence of Anabaena variabilis ATCC 29413.";
RL   Stand. Genomic Sci. 9:562-573(2014).
CC   -!- FUNCTION: Involved in light-induced Na(+)-dependent proton extrusion.
CC       Also seems to be involved in CO(2) transport. {ECO:0000255|HAMAP-
CC       Rule:MF_01308}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01308}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01308}.
CC   -!- SIMILARITY: Belongs to the Cema family. {ECO:0000305}.
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DR   EMBL; CP000117; ABA20806.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q3MDY0; -.
DR   SMR; Q3MDY0; -.
DR   STRING; 240292.Ava_1182; -.
DR   EnsemblBacteria; ABA20806; ABA20806; Ava_1182.
DR   KEGG; ava:Ava_1182; -.
DR   eggNOG; ENOG502Z8DN; Bacteria.
DR   HOGENOM; CLU_690401_0_0_3; -.
DR   OMA; PANRDFI; -.
DR   Proteomes; UP000002533; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015078; F:proton transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01308; CemA; 1.
DR   InterPro; IPR004282; CemA.
DR   PANTHER; PTHR33650; PTHR33650; 1.
DR   Pfam; PF03040; CemA; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Hydrogen ion transport; Ion transport;
KW   Membrane; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..467
FT                   /note="Proton extrusion protein PcxA"
FT                   /id="PRO_0000293495"
FT   TRANSMEM        249..269
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        352..372
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        391..411
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   TRANSMEM        427..447
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01308"
FT   REGION          183..205
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   467 AA;  53634 MW;  AA3A66F2333BE272 CRC64;
     MPTMRNSIFS EKVYPILLSA YRWYLRTPER SLEEAYKAAL NIKAIEDEHF NGNKIDFNSA
     IYSNSVMDYF ESDLAQELKT ARMRLTEFRF SRWFSNESHQ KAARKAGIEY PSSTVILEKL
     KFIDEIISKY IITDYEIAAP SGASDLQVRT TSLQPPENPS LTDSLRNNDI NKNNLVERIY
     TPTSPPQLIR PRTEQNKKPR GKADTTGILP RSILSTIGRL QIELDPNSEQ DVINNFRQAQ
     KRSIISIRFI LLLIIVPLLT HQLSKALIVS PIFNHFKKAD TEQIFLNSEM EEEALSTLHR
     FEERIKFENL ISNAPPLSAE AIETQIKEKA EEIAAEFRGE SANAIKNVFA DIFSVGAFIW
     LLLVSKPSIM VLKEFFDNVV YGLSDSAKAF IIILFTDVFV GFHSPHGWEV ILEGLSRHWG
     LPANRDFIFL FIATFPVILD TIFKYWIFRY LNRISPSAVA TYRNMNE