PCX_DROME
ID PCX_DROME Reviewed; 3413 AA.
AC P18490; O46074; Q95TI6; Q9W506;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 16-MAR-2016, sequence version 4.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Protein pecanex;
GN Name=pcx; ORFNames=CG3443;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Oregon-R;
RA Labonne S.G.;
RT "Unpublished 5' sequence from pecanex region.";
RL Submitted (OCT-1991) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Oregon-R;
RX PubMed=10731137; DOI=10.1126/science.287.5461.2220;
RA Benos P.V., Gatt M.K., Ashburner M., Murphy L., Harris D., Barrell B.G.,
RA Ferraz C., Vidal S., Brun C., Demailles J., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Borkova D., Minana B., Kafatos F.C.,
RA Louis C., Siden-Kiamos I., Bolshakov S., Papagiannakis G., Spanos L.,
RA Cox S., Madueno E., de Pablos B., Modolell J., Peter A., Schoettler P.,
RA Werner M., Mourkioti F., Beinert N., Dowe G., Schaefer U., Jaeckle H.,
RA Bucheton A., Callister D.M., Campbell L.A., Darlamitsou A., Henderson N.S.,
RA McMillan P.J., Salles C., Tait E.A., Valenti P., Saunders R.D.C.,
RA Glover D.M.;
RT "From sequence to chromosome: the tip of the X chromosome of D.
RT melanogaster.";
RL Science 287:2220-2222(2000).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1015-3413, AND DEVELOPMENTAL STAGE.
RC STRAIN=Oregon-R;
RX PubMed=2478400; DOI=10.1016/0012-1606(89)90127-9;
RA Labonne S.G., Sunitha I., Mahowald A.P.;
RT "Molecular genetics of pecanex, a maternal-effect neurogenic locus of
RT Drosophila melanogaster that potentially encodes a large transmembrane
RT protein.";
RL Dev. Biol. 136:1-16(1989).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2873-3413.
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- FUNCTION: Involved in neurogenesis.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically.
CC {ECO:0000269|PubMed:2478400}.
CC -!- SIMILARITY: Belongs to the pecanex family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA28747.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAA28749.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAL13981.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; M74329; AAA28747.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AE014298; AAF45756.3; -; Genomic_DNA.
DR EMBL; AL009195; CAA15708.1; -; Genomic_DNA.
DR EMBL; M25662; AAA28749.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AY058752; AAL13981.1; ALT_INIT; mRNA.
DR PIR; A37361; A37361.
DR PIR; T13423; T13423.
DR RefSeq; NP_001259182.1; NM_001272253.1.
DR RefSeq; NP_525045.3; NM_080306.4.
DR BioGRID; 57742; 6.
DR IntAct; P18490; 4.
DR STRING; 7227.FBpp0304656; -.
DR GlyGen; P18490; 21 sites.
DR PaxDb; P18490; -.
DR PRIDE; P18490; -.
DR EnsemblMetazoa; FBtr0332381; FBpp0304655; FBgn0003048.
DR EnsemblMetazoa; FBtr0344153; FBpp0310566; FBgn0003048.
DR GeneID; 31204; -.
DR KEGG; dme:Dmel_CG3443; -.
DR UCSC; CG3443-RB; d. melanogaster.
DR CTD; 18563; -.
DR FlyBase; FBgn0003048; pcx.
DR VEuPathDB; VectorBase:FBgn0003048; -.
DR eggNOG; KOG3604; Eukaryota.
DR GeneTree; ENSGT00940000168683; -.
DR InParanoid; P18490; -.
DR OMA; APQIMWF; -.
DR PhylomeDB; P18490; -.
DR SignaLink; P18490; -.
DR BioGRID-ORCS; 31204; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 31204; -.
DR PRO; PR:P18490; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0003048; Expressed in capitellum (Drosophila) and 23 other tissues.
DR ExpressionAtlas; P18490; baseline and differential.
DR Genevisible; P18490; DM.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:FlyBase.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007029; P:endoplasmic reticulum organization; IMP:FlyBase.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR InterPro; IPR039797; Pecanex.
DR InterPro; IPR007735; Pecanex_C.
DR PANTHER; PTHR12372; PTHR12372; 1.
DR Pfam; PF05041; Pecanex_C; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; Glycoprotein; Membrane;
KW Neurogenesis; Reference proteome; Repeat; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..3413
FT /note="Protein pecanex"
FT /id="PRO_0000215792"
FT TRANSMEM 33..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1315..1335
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1343..1363
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1376..1396
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1423..1443
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1474..1494
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1504..1524
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1830..1850
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1856..1876
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1914..1934
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1940..1960
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1976..1996
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REPEAT 1776..1777
FT /note="1"
FT REPEAT 1778..1779
FT /note="2"
FT REPEAT 1780..1781
FT /note="3"
FT REPEAT 1782..1783
FT /note="4"
FT REPEAT 1784..1785
FT /note="5"
FT REGION 182..213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 235..314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 327..363
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 379..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 540..609
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 625..651
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 720..745
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 816..873
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 886..921
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1002..1021
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1577..1675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1722..1744
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1760..1813
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1776..1785
FT /note="5 X 2 AA tandem repeats of G-T"
FT REGION 2344..2463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2908..2997
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3198..3242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3295..3413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 239..259
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 276..297
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 300..314
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 327..362
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 388..403
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 572..588
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 859..873
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1587..1633
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1634..1672
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1724..1744
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1774..1809
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2378..2421
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2445..2463
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2943..2957
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2978..2997
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3222..3236
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3320..3334
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3358..3380
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3382..3404
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 164
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 208
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 317
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 569
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 581
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 685
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 857
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1010
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1015
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1069
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1199
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1375
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1572
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1791
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1804
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2380
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2387
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2458
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2619
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2717
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3246
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 131
FT /note="G -> V (in Ref. 1 and 4)"
FT /evidence="ECO:0000305"
FT CONFLICT 211
FT /note="T -> I (in Ref. 1)"
FT /evidence="ECO:0000305"
FT CONFLICT 384
FT /note="R -> C (in Ref. 1)"
FT /evidence="ECO:0000305"
FT CONFLICT 439
FT /note="A -> G (in Ref. 1)"
FT /evidence="ECO:0000305"
FT CONFLICT 449
FT /note="L -> Q (in Ref. 1)"
FT /evidence="ECO:0000305"
FT CONFLICT 471
FT /note="L -> LL (in Ref. 1)"
FT /evidence="ECO:0000305"
FT CONFLICT 778
FT /note="V -> D (in Ref. 1; AAA28747)"
FT /evidence="ECO:0000305"
FT CONFLICT 1017
FT /note="Missing (in Ref. 5)"
FT /evidence="ECO:0000305"
FT CONFLICT 1042
FT /note="Missing (in Ref. 1; AAA28747)"
FT /evidence="ECO:0000305"
FT CONFLICT 1364
FT /note="Q -> L (in Ref. 1 and 5)"
FT /evidence="ECO:0000305"
FT CONFLICT 1368
FT /note="A -> R (in Ref. 1 and 5)"
FT /evidence="ECO:0000305"
FT CONFLICT 1683
FT /note="T -> A (in Ref. 1 and 5)"
FT /evidence="ECO:0000305"
FT CONFLICT 1799
FT /note="G -> R (in Ref. 1 and 5)"
FT /evidence="ECO:0000305"
FT CONFLICT 2543
FT /note="S -> C (in Ref. 1 and 5)"
FT /evidence="ECO:0000305"
FT CONFLICT 3048
FT /note="V -> M (in Ref. 6)"
FT /evidence="ECO:0000305"
FT CONFLICT 3053
FT /note="V -> G (in Ref. 6)"
FT /evidence="ECO:0000305"
FT CONFLICT 3111..3112
FT /note="MV -> NG (in Ref. 1 and 5)"
FT /evidence="ECO:0000305"
FT CONFLICT 3120
FT /note="T -> P (in Ref. 1 and 5)"
FT /evidence="ECO:0000305"
FT CONFLICT 3231
FT /note="T -> A (in Ref. 1 and 5)"
FT /evidence="ECO:0000305"
FT CONFLICT 3347
FT /note="D -> G (in Ref. 1 and 5)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 3413 AA; 365325 MW; F2E9C3E19AA7F951 CRC64;
MGSQTLEILR QGVWASLTGG YFYDPHQGVF CNVVHLYLWL YLLCSPFVAY LYFPSTWLTW
CLYCVITSLT ILMVKLANLA LHRLYDRAQT MSEGNLKGQF VKVTKETEPR HDDEGGIEMK
VIRPGGSRIS GEQAINEASE ENSIMSIDNV NSIIDLKVDV HRKNSSESIE LMFYAPSMLS
GGSQQDQQSL AGSASVSKSI RSTGPGGNSS TSAAAQADMF NKYLTVYPEV VEAAGSSAGS
ADGGSSGGDS RSGAAVSTLG HTGAGTAPAQ HVRTGHLSRK CSEVFSRRHR RRLERQSSLD
TAAAAANSNA ENKLMRNQSD TIATAAPSFL HSQPTNKARG QTNPRQHFIT SAPSTGIGGG
DAPTSSTAVV VIAPASNSLV NPGRSSRLQR HRSSETHDER LKHQSRGGLF QPILQLPHHS
AASSIGALAV LGGGGNVAAN DVEDMELGLV RNAGSGGVAD ACSRALQSWI LDPFPDGYLE
DDSYTKSDLG IEQPHQPTFR TQHRHHHHHH HLHHHLGGAI IRKDPTSTMS ALQLAAVTQP
GTGGSVTGGG GAAGGGGSAA GMKRRRHSNA TSYKHGSSQS NKSSLVGGGG SRGPSGEAGT
SGGAGGTGGV RRIKSAALEV LCPQPSVSNL SPHPNSVEAI SGQQQMRNPL PPPSKSLVRN
QHLNLYPTQG YGDGTPSAGG GGPGNSSTCS SLFFGSSSAC GSTTALIEPP VYPIVEHSDE
KTAHEEHGDD CLGIGQGNAD DDDEVDDVPI RRRTRALGCS QTHYSVESDV GGFLADEVGA
DEDVFKDFDD NLEHILSELQ QTHNQLDDVL KTHDLHHHSH LHHHKAASVE GAGPSGGSVA
VGVSAGNDDE DEETEDNNTG SRSPLLNDRN RQPATLREIQ ADKQLRQELS HQSGAVIPAP
NPPVPIRSEA DSGCPSSDCE QVSASSKDQL LSGIELELQQ YQILQRCQLD EEQPCTSKMA
AKSLGAIPKV VKYREVDELR RRRRGGSPAD AAEAGNEFAL VKQTKQASRN SSSSNSTHSI
SLTDSLTADI HKMLWLMHGG AVDDRGRPIT GTSADGTPIP ASSSLVPPNM SNAHFQFYQD
AIQALQGTHP TSGSSVEHMT NIELARDKLR LDAKLMCEQL VAAAEANSGV RGNTLATQQM
TQQQVGMLMR GGSSSRHPSS APFSVQGLIN VIRSERPAAR SQLDALQQLS DAAAALAANA
SEAASVSASG AGGGASSGGG GVLSALGLAN HPSNQISQIS QLSQMSQPML NVDGHFAPYC
DYWRPACLLS ATEKPAAPKS FYKYRFKWCG QEHEFKIAMD RLELLALFDR DLHWMHVLLA
SLLCTLVACL GAAILQHDHY KDLCALLFCA VIAGAQYSLV KSVQPDAASP VHGFNKTVAY
SRAIYFCLAG GMLLLLKRLD TDYGERTPDP VVFFGMRYSP ADVVALLLQA LYILLLCFPI
IFSVGLCPQI NTFLMYLLEQ IDMHVFGGNA ASSLLGSFLC VVRSVLAVML LYGPLYGALD
EQRGTQYILF SIFCAMLVPL GYHLSRCASD FSHLWRLIKT CIVSTYRDDE DEDLSQMQHI
ATGTVTGSGT ANSTALQLTT STPKQHRQTD VKTEHEQIEL SSLEKLTVNE EHHEKDHGAD
DQLETDQDLP LQQKHSKSKT SSLGSSQQTL GKTISSSKRA ITASSSCTSI GTGEPAVEAG
ALTEEAVEGE EQRRNTLAGE VGSKHELAEN YDQAAKIDEC EDKISSSSAT NPGDMSTLTA
GAGTATTDAT PACLEADPDA EAEAPADEKQ HQGILGTGTG TGTGTTEASE NGSGGGANGN
TNSNGTGNDL PDPLPRKLQA TVTTRLKNDL VVMTLLAVSV LGLHCSTVFT ALQPDLNVVL
YSFIGVLGLL LHYIVPQMRK HMPWLCFSRP LLRQREFGQF EVLNAPKIMW FEKLYIYLSV
LERNVLFPLL AISSLTADSQ LIVAKFGLPW GTLIVAICAL KFVRNAYSDP TNQYLIIIFT
VLLFRIDFAM ATETFIIDYF FVSLAFRKCC DFLLKLQFIV TYIAPWQITW GSAFHAFAQP
FSVPHSAMLF LQAAISAVLS TPLNPFLGSA IFLTSYVRPI KFWERDYNTR RIDHSNTRLS
SQLERDLGAD DNNLNSIFYE HLTRSLQHSL CGDLLMGRWG NVNQGDCFVL ASDDLNCLVH
IIELGNGLCT FQMRGLEFRG TYCQQREVEA ITEDVEDNDG CCCCDPGHLP QLLSANAMFS
TRWLAWQVVA AQYVIEGYSI SDNLASATLQ VFEYRKVLIT YYIKSIIYYV VKNPKLEQWL
ASGPIQDALQ HTLSRQFVDL DPIFNFNLDE DFDFRAVGIT RSSFCYVYLK WINYCVDMRR
DANSMGGAPP AQAPAAAGGA SSAPATAGVA PPAPVTPAHN DSKSTPNLSA HGGQAGPSSG
QSKSQSQQQL RRPQKSVAQE TSVGGGGVVV GGTTVPGTGG VTGGGGDPQL SSSHSFANIS
RQTSESAPGL GGYVAYMDQN VFVKLAKSST TTGAGAGAPT SRKESQEKPA LRLKLASVGK
DAPLVSLCLA LGLLARRSLA TASHSALTGV EFFLHGLHAL FKGDFRITSP RDEWVFADME
LLHSVVAPAV KMALKLQQDH ITNPDEFLDP HALYDAIDNC SNELVISHEA DPVWRSAVLR
GAPNLLALRH VMEDGSDEYR IIRLTKRCLS FRVIKLNREC VRGLWAGQQQ ELIYLRNRNP
ERGSIQNAKQ ALRNIINSSC DQPIGYPIYV SPLTTSYADT NAQLCEVIGG AITLDTIRHT
VLGWWHRIRE RCRQGCSSGS ALEPHPGSGP VQLGACNFGS GGSVVGAAST ATGVGASTGS
GLGVAAPGTA GSTGGESGDL APVFISAPLY NTLTVNSYYS VRPGNVPGGP IPGNLGGNYV
SDSLAVVRGG LAVMPVKPTS TTLIAGLLNR ERDETSGSGI MGAGASGPTR ATSSGGVRSR
RPEVGSSRGR DHERRATLPI ASGGAGGEPG KDLTAPQTQV EHEPSPRSTK LSSSSGSLGL
GMGVGLGNII TTPGDYPRKT KGPICLTAVD TGTSSSAAEG KPAGSGTVAG TGVGGVIRKP
RIEIFKKVII VDDTGIYDCL DIIDAVVWPT ERMRNNGGRL SWKDWEPSAG MVGHVVHCWT
PNHKDIRFRS HVNRYVYLVE IGDHYVPVEE LGLREYNQIM GSTEEMANSR RSSIQRDFHE
YNIQLKLAGL APIIGGGESS TATTSDASKS HKAKIRAVSS SSSEDEDTSS TRSIPLPQGD
DGDLTNFTRL VSMWKEIILD NNKRRLYDMG ELSPELLQKL DDAVQQQQQL EDALAEESKE
KGTATVTANE GEEGVGEMEI EPEQEQKEVV YLEEQSPLEE VTVSKPDEQP AQPTIPASPV
PAETSSTSSA KSTSSPSLCQ EEEDAVDPEE TPELASEESP SDENGESEAG TTV
