ASPM_HYLLA
ID ASPM_HYLLA Reviewed; 3477 AA.
AC P62290;
DT 05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=Abnormal spindle-like microcephaly-associated protein homolog;
GN Name=ASPM;
OS Hylobates lar (Common gibbon) (White-handed gibbon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Hylobates.
OX NCBI_TaxID=9580;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=14722158; DOI=10.1093/hmg/ddh055;
RA Evans P.D., Anderson J.R., Vallender E.J., Gilbert S.L., Malcom C.M.,
RA Dorus S., Lahn B.T.;
RT "Adaptive evolution of ASPM, a major determinant of cerebral cortical size
RT in humans.";
RL Hum. Mol. Genet. 13:489-494(2004).
CC -!- FUNCTION: Probable role in mitotic spindle regulation and coordination
CC of mitotic processes. May have a preferential role in regulating
CC neurogenesis (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton,
CC spindle {ECO:0000250}. Nucleus {ECO:0000250}. Note=The nuclear-
CC cytoplasmic distribution could be regulated by the availability of
CC calmodulin. Localizes to spindle poles during mitosis (By similarity).
CC {ECO:0000250}.
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DR EMBL; AY488994; AAR84354.1; -; Genomic_DNA.
DR EMBL; AY488967; AAR84354.1; JOINED; Genomic_DNA.
DR EMBL; AY488968; AAR84354.1; JOINED; Genomic_DNA.
DR EMBL; AY488969; AAR84354.1; JOINED; Genomic_DNA.
DR EMBL; AY488970; AAR84354.1; JOINED; Genomic_DNA.
DR EMBL; AY488971; AAR84354.1; JOINED; Genomic_DNA.
DR EMBL; AY488972; AAR84354.1; JOINED; Genomic_DNA.
DR EMBL; AY488973; AAR84354.1; JOINED; Genomic_DNA.
DR EMBL; AY488974; AAR84354.1; JOINED; Genomic_DNA.
DR EMBL; AY488975; AAR84354.1; JOINED; Genomic_DNA.
DR EMBL; AY488976; AAR84354.1; JOINED; Genomic_DNA.
DR EMBL; AY488977; AAR84354.1; JOINED; Genomic_DNA.
DR EMBL; AY488978; AAR84354.1; JOINED; Genomic_DNA.
DR EMBL; AY488979; AAR84354.1; JOINED; Genomic_DNA.
DR EMBL; AY488980; AAR84354.1; JOINED; Genomic_DNA.
DR EMBL; AY488981; AAR84354.1; JOINED; Genomic_DNA.
DR EMBL; AY488982; AAR84354.1; JOINED; Genomic_DNA.
DR EMBL; AY488983; AAR84354.1; JOINED; Genomic_DNA.
DR EMBL; AY488984; AAR84354.1; JOINED; Genomic_DNA.
DR EMBL; AY488985; AAR84354.1; JOINED; Genomic_DNA.
DR EMBL; AY488986; AAR84354.1; JOINED; Genomic_DNA.
DR EMBL; AY488987; AAR84354.1; JOINED; Genomic_DNA.
DR EMBL; AY488988; AAR84354.1; JOINED; Genomic_DNA.
DR EMBL; AY488989; AAR84354.1; JOINED; Genomic_DNA.
DR EMBL; AY488990; AAR84354.1; JOINED; Genomic_DNA.
DR EMBL; AY488991; AAR84354.1; JOINED; Genomic_DNA.
DR EMBL; AY488992; AAR84354.1; JOINED; Genomic_DNA.
DR EMBL; AY488993; AAR84354.1; JOINED; Genomic_DNA.
DR PRIDE; P62290; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007051; P:spindle organization; IEA:InterPro.
DR Gene3D; 1.10.418.10; -; 2.
DR Gene3D; 1.25.10.10; -; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR031549; ASH.
DR InterPro; IPR029955; ASPM.
DR InterPro; IPR001715; CH-domain.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR22590:SF4; PTHR22590:SF4; 6.
DR Pfam; PF15780; ASH; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00612; IQ; 37.
DR SMART; SM00033; CH; 1.
DR SMART; SM00015; IQ; 63.
DR SUPFAM; SSF47576; SSF47576; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR SUPFAM; SSF52540; SSF52540; 17.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50096; IQ; 36.
PE 3: Inferred from homology;
KW Calmodulin-binding; Cell cycle; Cell division; Coiled coil; Cytoplasm;
KW Cytoskeleton; Mitosis; Nucleus; Phosphoprotein; Repeat.
FT CHAIN 1..3477
FT /note="Abnormal spindle-like microcephaly-associated
FT protein homolog"
FT /id="PRO_0000191333"
FT DOMAIN 920..1056
FT /note="Calponin-homology (CH) 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT DOMAIN 1110..1261
FT /note="Calponin-homology (CH) 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT DOMAIN 1347..1378
FT /note="IQ 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1393..1422
FT /note="IQ 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1582..1613
FT /note="IQ 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1632..1661
FT /note="IQ 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1655..1684
FT /note="IQ 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1728..1757
FT /note="IQ 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1751..1782
FT /note="IQ 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1801..1830
FT /note="IQ 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1824..1853
FT /note="IQ 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1874..1903
FT /note="IQ 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1947..1978
FT /note="IQ 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1970..2001
FT /note="IQ 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2020..2049
FT /note="IQ 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2043..2074
FT /note="IQ 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2093..2124
FT /note="IQ 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2116..2147
FT /note="IQ 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2189..2218
FT /note="IQ 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2239..2270
FT /note="IQ 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2262..2293
FT /note="IQ 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2311..2342
FT /note="IQ 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2334..2365
FT /note="IQ 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2384..2415
FT /note="IQ 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2407..2438
FT /note="IQ 23"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2457..2488
FT /note="IQ 24"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2480..2511
FT /note="IQ 25"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2530..2561
FT /note="IQ 26"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2624..2653
FT /note="IQ 27"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2665..2696
FT /note="IQ 28"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2688..2719
FT /note="IQ 29"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2738..2767
FT /note="IQ 30"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2859..2890
FT /note="IQ 31"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2909..2938
FT /note="IQ 32"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2954..2985
FT /note="IQ 33"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 3029..3060
FT /note="IQ 34"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 3079..3110
FT /note="IQ 35"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 3204..3235
FT /note="IQ 36"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1058..1077
FT /evidence="ECO:0000255"
FT MOD_RES 280
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 283
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 367
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 392
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 425
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 605
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 1103
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
SQ SEQUENCE 3477 AA; 409718 MW; B14FC60AAC9EEA14 CRC64;
MANRRVGRGC WEVSPTERRP PAGLRGPAAE EEASSPPVLS LSHFCRSPFL CFGDVLLGAS
RTLSLALDNP NEEVAEVKIS RFPAADLGFS VSQRCFVLQP KEKIVISVNW TPFKEGRVRE
IMTFLVNDVL KHQAILLGNA EEQKKKKRSL WDTIKKKKIS ASTSHNRRVS NIQNVNKTFS
VSQKVDRVRS PLQACENLAM NEGGPPTENN SLTLEENKIP ISPISPAFNE CHGATCLPLS
VRRSTTYSSL HASENRELLN VDSANVSKVS FNEKAVTETS FNSINVNGQS GENSKLSLTP
NYSSTLNITQ SQIHFLSPDS FVNNSHGANN GLELVTCLSS DMFMKDNSKP VHLESTIAHE
INQKILSPDS FIKDNYGLNQ DLESESVNPI LSPNQFLKDN MAYMCTSQQT CKVPLSNENS
QVPQSPQDWR KSEVSPRIPE CQGSKSPKAI FEELVEMKSN YYSFINQNNP KFSAVQDISS
HSHNKQPKRR PILSATVTKR KATCTRENQT EINKPKAKRC LNSAVGEHEK VINNQKEKED
FHSYLPIIDP ILSKSKSYKN KITPSSTTAS VARKRKSDGS MEDANVRVAV TEHTEVREIK
RIHFSPSEPK TSAVKKTKNV ITPISKRISN REKLNLKKKT DLLMFKTPIS KTNKRTKPII
AVAQSSLTFI KPLKTDIPRH PLPFAAKNMF YDERWKEKQE QGFTWWLNFI LTPDDFTVKT
NTSEVNAATL LLGIENQHKI SVPRAPTKEE MSLRAYTARC RLNRLRRAAC RLFTSEKMVK
AIKKLEIEIE ARRLIVRKDR HLWKDVGERQ KVLNWLLSYN PLWLRIGLET TYGELISLED
NSDVTGLAMF ILNRLLWNPD IAAEYRHPTV PHLYRDGHEE ALSKFTLKKL LLLVCFLDYA
KISRLIDHDP CLFCKDAEFK ASKEILLAFS RDFLSGEGDL SRHLGLLGLP VNHVQTPFDE
FDFAVTNLAV DLQCGVRLVR TVELLTQNWD LSKKLRIPAI SRLQKMHNVD IVLQVLKSRG
IELSDEHGNT ILSKDIVDRH REKTLRLLWK IAFAFQVDIX LNLDQLKEEI AFLKHTKGIK
KTISLLSCHY DDLINKKKGK RDSDSFEQYS ENIKLLMDWV NAVCXFYNKK VENFTVSFSD
GRVLCYLIHH YHPCYVPFDA ICQRTTQTVE CTQTGSVVLN SSSESDDSSL DMSLKAFDHE
NTSELYKELL ENEKKNFQLV RSAVRDLGGI PAMINHSDMS NTIPDEKVVI TYLSFLCARL
LDLRKEIRAA RLIQTTWRKY KLKTDLKRHQ ETDKAARIIQ SAVINFLAKQ RLRKRVNAAL
VIQKYWRRVL AQRKLLMLKK EKLEKVQNKA ASLIQGYWRR YSTRKRFLKL KYYSIILQSR
IRMIIAVTSY KRYLWATVTI QRHWRAYLRR KQDQQRYEML KSSTLIIQSM FRKWKQRKMQ
SQVKATIILQ RAFREWHLRK QAKEENSAIV IQSWYRMHKE LRKYIYIRSC XVIIQKRFRC
FQAQKLYKRK KESILTIQKY YKAYLKGKIE RTNYLQKRAA AIRLQAAFRR LKAHNLCRQI
RAACVIQSYW RMRQDRVRFL NLKKTIIKLQ AHVRKHQQLQ KYKKMKKAAV IIQTHFRAXI
FARKVLASYQ KTRSAVIVLQ SAYRGMQARK MYIHILTSVI KIQSYYRAYV SKKEFLSLKN
ATIKLQSIVK MKQTRXQYLH LRAAALFIQQ CYRSKKIAAQ KREEYMQMRE SCIKLQAFVR
GYLVRKQMRL QRKAVISLQS YFRMRKARQY YLKMYKAIIV IQNYYHAYKA QVNQRKNFLQ
VKKAATCLQA AYRGYKVRQL IKQQSIAALK IQSAFRGYNK RVKYQSMLQS IIKIQRWYRA
YKTLHDTRTH FLKTKAAVIS LQSAYRGWKV RKQIRREHQA ALTIQSAFRM AKAQXQFRLF
KTAALVIQQN FRAWTAGRKQ RMEYIELRHA VLMLQSMWKG KTLRRQLQRQ HKCAIIIQSY
YRMHVQQKKW KTMKKAALLI QKYYRAYSIG REQNHLYLKT KVAVVTLQSA YRGMKVRKRI
KDCNKAAVTI QSKYRAYKTK KKYATYRASA IIIQRWYRGI KITNHQHKKY LNLKKTAIKI
QSVYRGIRVR RHIQHMHRAA TFIKAMFKMH QSRISYHTMR KAAIVIQVRF RAYYQGKMQR
EKYLTILKAV KILQASFRGV RVRWTLRKMQ IAATLIQSNY RRYRQQTYFN KLKKITKTVQ
QRYRAMKERN IQFQRYNKLR HSVIYIQAIF RGKKARRHLK MMHIAATVIQ RRFRTLMMRR
RFLSLKKTAI WIQRKYRAHL CTKHHLQFLQ VQNAVIKIQS SYRRWMIRKR MREMHRAATF
IQATFRMHRL HMRYQALKQA SVVIQQQYQA NRAAKLQRQH YLRQRHSAVI LQAAFRGMKT
RRHLXSMHFS ATLIQSRFRS LLVRRRFISL KKATIFVQRK YRATICAKHK LHQFLHLRKA
AITIQSSYRR LMVKKKLQEM QRAAVLIQAT FRMHRTYITF RTWKHASILI QQHYRTYRAA
KLRRENYIRQ WHSAVVIQAA YKGMKARQLL REKHKAAIII QSTYRMYRQY CFYQKLQWAT
KIIQEKYRAN KKQQKAFQHN ELKKETCVQA SFQDMNIKKQ IXEQHQAAII IQKHCKAFKI
RKHYLHLRAT VVSIQRRHRK LAAVRTQAVI CIQSYYRGFK VRRDIQNMHQ AATLIQSFYR
MHKAKVDYQT KKTAIVVIQN YYRLYVRVKT ERKSFLAVQK SVRTIQAAFR GMKVRQKLKN
VSEERMAAVV NQSALCCYRS KTQYEAVQSE GVMIQEWYKA SGLACSQEAE YHSQSRAAVT
IQKAFCRMAT RKLETQKCAA LRIQFFFQMA VYRRRFVQQK RAAITLQHYF RTWQTRKQFL
LYRKAAVVLQ NHYRAFLSAK HQRQVYLQIR SSVIIIQARS KGFIQKRKFQ QIKNSTIKIQ
AMWRRXRAKK YLCKVKAACK IQAWYRCWRA HKEYLAILKA VKIIQGCFYT KLERTRFLNV
RASAIIIQRK WRAILSAKIA HEHFLMIKRH RAACLIQAHY RGYKGRQVFL RQKSAALIIQ
KYIRAREAGK RERIKYIEFK KSTVILQALV RGWLVRKRII EQRAKIRLLH FTAAAYYHLN
ALRIQRXYKL YLAVKNANKQ INSVICIQRW FRARLQQKRF IQKYHSIKKI EHEGQECLSQ
RNRAASVIQK AVXHFLLRKK QEKFTNGIIK IQALWRGYSW RKKNDCTKIK AIRLSLQVVN
REIREENKLY KRTALALHYL LTYKHLSAIL EALKHLEVVT RLSPLCCENM AQSGAISKIF
VLIRSCNRSV PCMEVIRYAV QVLLNVSKYE KTTSAVYDVE NCIDILLELL QIYREKPGNK
VADKGGSIFT KTCCLLAILL KTTNRASDVR SRSKVVDRIY SLYKLTAHKH KMNTERILYK
QKKNSSISIP FIPETPVRTR IVSRLKPDWV LRRDNMEEIT NPLQAIQMVM DTLGIPY
