ASPM_MACFA
ID ASPM_MACFA Reviewed; 3476 AA.
AC P62291;
DT 05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Abnormal spindle-like microcephaly-associated protein homolog;
GN Name=ASPM;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=14722158; DOI=10.1093/hmg/ddh055;
RA Evans P.D., Anderson J.R., Vallender E.J., Gilbert S.L., Malcom C.M.,
RA Dorus S., Lahn B.T.;
RT "Adaptive evolution of ASPM, a major determinant of cerebral cortical size
RT in humans.";
RL Hum. Mol. Genet. 13:489-494(2004).
CC -!- FUNCTION: Probable role in mitotic spindle regulation and coordination
CC of mitotic processes. May have a preferential role in regulating
CC neurogenesis (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton,
CC spindle {ECO:0000250}. Nucleus {ECO:0000250}. Note=The nuclear-
CC cytoplasmic distribution could be regulated by the availability of
CC calmodulin. Localizes to spindle poles during mitosis (By similarity).
CC {ECO:0000250}.
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DR EMBL; AY485418; AAR98739.1; -; mRNA.
DR RefSeq; NP_001306293.1; NM_001319364.1.
DR STRING; 9541.XP_005540367.1; -.
DR PRIDE; P62291; -.
DR GeneID; 102137528; -.
DR CTD; 259266; -.
DR eggNOG; KOG0165; Eukaryota.
DR Proteomes; UP000233100; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007051; P:spindle organization; IEA:InterPro.
DR Gene3D; 1.10.418.10; -; 2.
DR Gene3D; 1.25.10.10; -; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR031549; ASH.
DR InterPro; IPR029955; ASPM.
DR InterPro; IPR001715; CH-domain.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR22590:SF4; PTHR22590:SF4; 6.
DR Pfam; PF15780; ASH; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00612; IQ; 41.
DR SMART; SM00033; CH; 1.
DR SMART; SM00015; IQ; 66.
DR SUPFAM; SSF47576; SSF47576; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR SUPFAM; SSF52540; SSF52540; 17.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50096; IQ; 38.
PE 2: Evidence at transcript level;
KW Calmodulin-binding; Cell cycle; Cell division; Coiled coil; Cytoplasm;
KW Cytoskeleton; Mitosis; Nucleus; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..3476
FT /note="Abnormal spindle-like microcephaly-associated
FT protein homolog"
FT /id="PRO_0000191334"
FT DOMAIN 920..1056
FT /note="Calponin-homology (CH) 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT DOMAIN 1110..1261
FT /note="Calponin-homology (CH) 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT DOMAIN 1347..1378
FT /note="IQ 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1393..1422
FT /note="IQ 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1582..1613
FT /note="IQ 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1605..1634
FT /note="IQ 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1632..1661
FT /note="IQ 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1655..1684
FT /note="IQ 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1728..1757
FT /note="IQ 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1751..1782
FT /note="IQ 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1801..1830
FT /note="IQ 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1824..1853
FT /note="IQ 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1874..1903
FT /note="IQ 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1897..1928
FT /note="IQ 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1947..1978
FT /note="IQ 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1970..2001
FT /note="IQ 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2020..2049
FT /note="IQ 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2043..2074
FT /note="IQ 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2093..2124
FT /note="IQ 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2116..2147
FT /note="IQ 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2239..2270
FT /note="IQ 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2262..2293
FT /note="IQ 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2311..2342
FT /note="IQ 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2334..2365
FT /note="IQ 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2384..2415
FT /note="IQ 23"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2407..2438
FT /note="IQ 24"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2457..2488
FT /note="IQ 25"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2530..2561
FT /note="IQ 26"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2624..2653
FT /note="IQ 27"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2665..2696
FT /note="IQ 28"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2688..2719
FT /note="IQ 29"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2738..2767
FT /note="IQ 30"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2814..2845
FT /note="IQ 31"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2859..2890
FT /note="IQ 32"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2909..2938
FT /note="IQ 33"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2932..2963
FT /note="IQ 34"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2954..2985
FT /note="IQ 35"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 3029..3060
FT /note="IQ 36"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 3079..3110
FT /note="IQ 37"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 3203..3234
FT /note="IQ 38"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 417..438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1057..1078
FT /evidence="ECO:0000255"
FT COMPBIAS 417..432
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 280
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 283
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 367
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 392
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 425
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 605
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 1103
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
SQ SEQUENCE 3476 AA; 409426 MW; 90A35BDD37EE7DB5 CRC64;
MANRRVGRGC WEVSPTERRP PAGLRGPATE EEASSPPVLS LSHFCRSPFL CFGDVLLGDS
RTLPLALDNP NEEVAEVKIS HFPAADLGFS VSQRCFVLQP KEKIVISVNW TPFKEGRVRE
IMTFLVNDVL KHQAILLGNA EKQKKKKRSL WDTIKKKKIS ASTSHNRRVS NIQNVNKTFS
VSQKVDRVRS PLQACENLAM NEGGPPTENN SLTLEENKIP ISPISPAFNE CHGATCLPLS
VRRSTTYSSL HASENRELLN VDSANVSKVS FNEKAVTETS FNSINVNDQS GENSKLILTP
NYSSTLNITQ SQINFLSPDS FVNNSHGANN ELELVTCLSS DMFMTDNSKP VPLQSTIAHE
IYQKILSPDS FIKDNYGLNQ DLESESVNPI LSPNQFLKDN MAYMCTSQQT YKVPLSNENS
QVPQSPQDWS KSEVSPCIPE YQGSKSPKAI FEELVEMKSN YYSFIKQNNP KFSAVQDISS
HSHDKQPKRR PILSATVTKR KPTCTRENQT EINKPKAKRC LNSAVGEHEK VIHNQKEKED
FHSYLPVIDP VLSKSKSYKN QIMPSLTTAS VARKRKSDGS MEDANVRVAV TEHTEEREIK
RIHFSPSEPK TSAVKKTKNV ITPISKCISN REKLNLKKKT DLLIFKTPIS KTSKRTKPII
AVAQSNLTFI KPLKTDIPRH PMPFAAKNMF YDERWKEKQE QGFTWWLNFI LTPDDFTVKT
NISEVNAATL LLGVENQHKI SVPRAPTKEE MSLRAYTARC RLNRLRRAAC RLFTSEKMVK
AIKKLEIEIE ARRLIVRKDR HLWKDVGERQ KVLNWLLSYN PLWLRIGLET IYGELISLED
NSDVTGLAMF ILNRLLWNPD IAAEYRHPTV PHLYRDGHEG ALSKFTLKKL LLLICFLDYA
KISXLIDHDP CLFCKDAEFK ASKEILLAFS RDFLSGEGDL SRHLGLLGLP VNHVQTPFDE
FDFAITNLAV DLQCGVRLVR TMELLTQNWN LSKKLRIPAI SRLQKMHNVD IVLQVLKSRG
IELSDEHGNT ILSKDIVDRH REKTLRLLWK IAFAFQVDIS LNLDQLKEEI AFLKHTKSIK
KTISLLSCHS DALINKKKGK RDSGSFEQYS ENIKLLMDWV NAVCAFYNKK VENFTVSFSD
GRVLCYLIHH YHPCYVPXDA ICQRTTQTVE CTQTGSVVLN SSSESDDSSL DMSLKAFDHE
NTSELYKELL ENEKKNFQLI RSAVRDLGGI PAMINHSDMS NTIPDEKVVI TYLSFLCARL
LDLRKEIRAA RLIQTTWRKY KLKTDLKRHQ ERDKAARIIQ SAVINFLAKQ RLRKRVNAAL
IIQKYWRRVL AQRKLLILKK EKLEKVQNKA ASLIQGYWRR YSTRKRFLKL KYYSIILQSR
IRMIIAVTSY KRYLWATVTI QRHWRAYLRR KQDQQRYEML KSSSLIIQSM FRKWKRRKMQ
SQVKATVILQ RAFREWHLRK RAKEENSAIV IQSWYRMHKE LRKYIYIRSC VIVIQKRFRC
FQAQKLYKRK KESILTIQKY YKAYLKGKIE RTNYLQKRAA AIQLQAAFRR LKAHNLCRQI
RAACVIQSYW RMRQDRVRFL NLKKTIIKLQ AHIRKHQQVQ KYKKMKKAAV IIQTHFRAYI
FTRKVLASYQ KTRSAVIVLQ SAYRGMQARK VYIHILTSVI KIQSYYRAYV SKKEFLSLKN
TTIKLQSIVK MKQTRKQYLH LRAAALFIQQ CYRSKKITTQ KREEYMQMRE SCIKLQAFVR
GYLVRKQMRL QRKAVISLQS YFRMRKARQY YLKMCKAIIV IQNYYHAYKA QVNQRKNFLR
VKKAATCLQA AYRGYKVRQL IKQQSIAALK IQSAFRGYNK RVKYQSVLQS IIKIQRWYRA
YKTLHDTRTR FLKTKAAVVS LQSAYRGWKV RKQIRREHQA ALKIQSAFRM AKAQKQFRLF
KTAALVIQQN FRAWTAGRKQ RMEYIELRHA VLILQSMWKG KTLRRQLQRQ XKCAIIIQSY
YRMHVQQKKW KIMKKAALLI QKYYKAYSIG REQHHLYLKT KAAVVTLQSA YRGMKVRKRI
KDCNKAAVTI QSKYRAYKTK KKYATYRASA IIIQRWYRGI KITHXXHQEY LNLKKTAIKI
QSVYRGIRVR RHIQHMHRAA TFIKAMFKMH QSRISYHTMR KAAIVIQVRF RAYYQGKMHR
EKYLTILKAV KILQASFRGV XVRWTLRKMQ IAATLIQSNY RRYKQQTYFN KLKKITKTIQ
QRYRAVKERN IQFKRYNKLR HSVIYIQAIF RGKKARRHLK MMHVAATLIQ RRFRTLMMRR
RFLSLKKTAV WIQRKYRAHL CTKHHLQFLQ VQNAVIKIQS SYRRWMIRKK MREMHRAATF
IQATFRMHRV HMRYQALKQA SVVIQQQYXA NRAAKLQRQH YLRQRRSAVI LQAAFRGVKT
RRHLKSMHSS ATLIQSRFRS LLVRRRFISL KKATIFVQRK YRATICAKHK LHQFLQLRKA
AITIQSSYRR LMVKKKLQEM QRAAVLIQAT FRMHRTCVTF QTWKQASILI QQHYRTYRAA
KLQKENYIRQ WHSAVVIQTA YKGMKARQHL REKHKAAIII QSTYRMYRQY CFYQKLQWAT
KIIQEKYRAN KKKQKALQHN ELKKETCVQA SFQDMNIQKQ IQEQHQAAII IQKHCKAFKI
RKHYLHLRAT VVSIQRRYRK LTAVRTQAVI CIQSYYRGFK VRRDIQNMHR AATLIQSFYR
MHRAKVDYQT KKTAIVVIQN YYRLYVRVKT ERKSFLPVQK SVRTIQAAFR GMKVRQKLKI
VSEEKMAAIV NQSALCCYRS KTQYEAVQSE GVMIQEWYKA SDLACSQEAE CHSQSRAAVT
IQNAFRRMVT RKLETQKCAA LRIQFFLQMA VYRRRFVQQK RAAITLQHYF RTWQTRKQFL
LYRKAAVVLQ NHYRAFLSAK HQRQVYLQIR SSVIIIQARS KGFIQKRKFQ EIKNSTIKIQ
AMWRRYRAKK YLCKVKAACK IQAWYRCWRA HKEYLAILKA VKIIQGCFYT KLERTWFLNV
RASAIIIQRK WRAILSAKIA HEHFLMIKRH RAACLIQAHY RGYKERQVFL RQKSAALIIQ
KYIRAREAGK RERIKYIEFK KSTVILQALV RGWLVRKRIL EQKTKIRLLH FTAAAYYHLN
ALRIQRAYKL YLAVKNANKQ VNSVICIQRW FRARLQQKKF IQKYSIKKIE HEGQECLSQQ
NRAASVIQKA VRHFVLRKKQ EKFTSGIIKI QALWRGYSWR KKNDCTKIKA IRLSLQVVNR
EIREENKLYK RTALALHYLL TYKHLSAILE ALKHLEVVTR LSPLCCENMA QSGAISKIFV
LIRSCNRSVP CMEVIRYAVQ VLLNVSKYEK TTSAVYDVEN CIDTLLELLQ IYREKPGNKV
ADKGGSIFTK TCCLLAVLLK TTNRASDVRS RSKVVDRIYS LYKLTAHKHK MNTERILHKQ
KKNSSISIPF IPXTPVRTRI VSRLKPDWVL RRDNMEEITN PLQAIQMVMD TLGIPY
