ID   PCYA_PROMA              Reviewed;         247 AA.
AC   Q7VCC2;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Phycocyanobilin:ferredoxin oxidoreductase;
DE            EC=1.3.7.5;
GN   Name=pcyA; OrderedLocusNames=Pro_0819;
OS   Prochlorococcus marinus (strain SARG / CCMP1375 / SS120).
OC   Bacteria; Cyanobacteria; Synechococcales; Prochlorococcaceae;
OC   Prochlorococcus.
OX   NCBI_TaxID=167539;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SARG / CCMP1375 / SS120;
RX   PubMed=12917486; DOI=10.1073/pnas.1733211100;
RA   Dufresne A., Salanoubat M., Partensky F., Artiguenave F., Axmann I.M.,
RA   Barbe V., Duprat S., Galperin M.Y., Koonin E.V., Le Gall F., Makarova K.S.,
RA   Ostrowski M., Oztas S., Robert C., Rogozin I.B., Scanlan D.J.,
RA   Tandeau de Marsac N., Weissenbach J., Wincker P., Wolf Y.I., Hess W.R.;
RT   "Genome sequence of the cyanobacterium Prochlorococcus marinus SS120, a
RT   nearly minimal oxyphototrophic genome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:10020-10025(2003).
CC   -!- FUNCTION: Catalyzes the four-electron reduction of biliverdin IX-alpha
CC       (2-electron reduction at both the A and D rings); the reaction proceeds
CC       via an isolatable 2-electron intermediate, 181,182-dihydrobiliverdin.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(2R,3Z)-phycocyanobilin + 4 oxidized [2Fe-2S]-[ferredoxin] =
CC         biliverdin IXalpha + 4 H(+) + 4 reduced [2Fe-2S]-[ferredoxin];
CC         Xref=Rhea:RHEA:15309, Rhea:RHEA-COMP:10000, Rhea:RHEA-COMP:10001,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738,
CC         ChEBI:CHEBI:57437, ChEBI:CHEBI:57991; EC=1.3.7.5;
CC   -!- SIMILARITY: Belongs to the HY2 family. {ECO:0000305}.
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DR   EMBL; AE017126; AAP99863.1; -; Genomic_DNA.
DR   RefSeq; NP_875211.1; NC_005042.1.
DR   RefSeq; WP_011124971.1; NC_005042.1.
DR   AlphaFoldDB; Q7VCC2; -.
DR   SMR; Q7VCC2; -.
DR   STRING; 167539.Pro_0819; -.
DR   EnsemblBacteria; AAP99863; AAP99863; Pro_0819.
DR   GeneID; 54200166; -.
DR   KEGG; pma:Pro_0819; -.
DR   PATRIC; fig|167539.5.peg.866; -.
DR   eggNOG; ENOG502Z7RN; Bacteria.
DR   HOGENOM; CLU_074224_0_0_3; -.
DR   OMA; YQTPQFR; -.
DR   OrthoDB; 1105902at2; -.
DR   Proteomes; UP000001420; Chromosome.
DR   GO; GO:0050897; F:cobalt ion binding; IEA:InterPro.
DR   GO; GO:0050620; F:phycocyanobilin:ferredoxin oxidoreductase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0010024; P:phytochromobilin biosynthetic process; IEA:InterPro.
DR   HAMAP; MF_00618; Ferredoxin_bilin_red; 1.
DR   InterPro; IPR009249; Ferredoxin-dep_bilin_Rdtase.
DR   InterPro; IPR022870; Ferredoxin_bilin_OxRdtase.
DR   PANTHER; PTHR34557; PTHR34557; 1.
DR   Pfam; PF05996; Fe_bilin_red; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase; Reference proteome.
FT   CHAIN           1..247
FT                   /note="Phycocyanobilin:ferredoxin oxidoreductase"
FT                   /id="PRO_0000216741"
SQ   SEQUENCE   247 AA;  28253 MW;  86C0ACBF02A31993 CRC64;
     MFAKSFPLNP FLESVADRIR ERVKGLTGVE SLELAPDLKN IYGKTDGEDF FIFNELHQSR
     GFRKLHIETA VFEPSLEILH VVFFPDPAFD LPIFGVDLIA VPQGISAAIV DLSPVRDKLP
     RTIENQLAQI EIPSFEKVRK LPDWGDIFSS HVQFITPIGA EENGFFLDLV DKFLTILIDY
     SESIEPDLDD SPFTIERIEG QMYYCLQQKQ NDKTRNVLAK AFSPNWANQY IEMVLFDMPV
     HTKNLDN