ASPM_MACMU
ID ASPM_MACMU Reviewed; 3479 AA.
AC P62292;
DT 05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 23-FEB-2022, entry version 95.
DE RecName: Full=Abnormal spindle-like microcephaly-associated protein homolog;
GN Name=ASPM;
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=15045028; DOI=10.1371/journal.pbio.0020126;
RA Kouprina N., Pavlicek A., Mochida G.H., Solomon G., Gersch W., Yoon Y.-H.,
RA Collura R., Ruvolo M., Barrett J.C., Woods C.G., Walsh C.A., Jurka J.,
RA Larionov V.;
RT "Accelerated evolution of the ASPM gene controlling brain size begins prior
RT to human brain expansion.";
RL PLoS Biol. 2:653-663(2004).
CC -!- FUNCTION: Probable role in mitotic spindle regulation and coordination
CC of mitotic processes. May have a preferential role in regulating
CC neurogenesis (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton,
CC spindle {ECO:0000250}. Nucleus {ECO:0000250}. Note=The nuclear-
CC cytoplasmic distribution could be regulated by the availability of
CC calmodulin. Localizes to spindle poles during mitosis (By similarity).
CC {ECO:0000250}.
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DR EMBL; AY497013; AAS48529.1; -; Genomic_DNA.
DR RefSeq; NP_001098005.1; NM_001104535.1.
DR STRING; 9544.ENSMMUP00000000338; -.
DR PRIDE; P62292; -.
DR GeneID; 711153; -.
DR KEGG; mcc:711153; -.
DR CTD; 259266; -.
DR eggNOG; KOG0165; Eukaryota.
DR InParanoid; P62292; -.
DR OrthoDB; 482623at2759; -.
DR Proteomes; UP000006718; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007051; P:spindle organization; IEA:InterPro.
DR Gene3D; 1.10.418.10; -; 2.
DR Gene3D; 1.25.10.10; -; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR031549; ASH.
DR InterPro; IPR029955; ASPM.
DR InterPro; IPR001715; CH-domain.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR22590:SF4; PTHR22590:SF4; 5.
DR Pfam; PF15780; ASH; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00612; IQ; 40.
DR SMART; SM00033; CH; 1.
DR SMART; SM00015; IQ; 66.
DR SUPFAM; SSF47576; SSF47576; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR SUPFAM; SSF52540; SSF52540; 17.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50096; IQ; 37.
PE 3: Inferred from homology;
KW Calmodulin-binding; Cell cycle; Cell division; Coiled coil; Cytoplasm;
KW Cytoskeleton; Mitosis; Nucleus; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..3479
FT /note="Abnormal spindle-like microcephaly-associated
FT protein homolog"
FT /id="PRO_0000191335"
FT DOMAIN 920..1056
FT /note="Calponin-homology (CH) 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT DOMAIN 1110..1261
FT /note="Calponin-homology (CH) 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT DOMAIN 1347..1378
FT /note="IQ 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1393..1422
FT /note="IQ 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1582..1613
FT /note="IQ 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1605..1634
FT /note="IQ 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1632..1661
FT /note="IQ 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1655..1684
FT /note="IQ 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1728..1757
FT /note="IQ 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1751..1782
FT /note="IQ 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1801..1830
FT /note="IQ 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1824..1853
FT /note="IQ 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1874..1903
FT /note="IQ 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1897..1928
FT /note="IQ 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1947..1978
FT /note="IQ 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1970..2001
FT /note="IQ 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2020..2049
FT /note="IQ 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2043..2074
FT /note="IQ 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2093..2124
FT /note="IQ 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2116..2147
FT /note="IQ 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2239..2270
FT /note="IQ 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2262..2293
FT /note="IQ 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2311..2342
FT /note="IQ 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2334..2365
FT /note="IQ 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2384..2415
FT /note="IQ 23"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2407..2438
FT /note="IQ 24"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2533..2564
FT /note="IQ 25"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2627..2656
FT /note="IQ 26"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2668..2699
FT /note="IQ 27"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2691..2722
FT /note="IQ 28"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2741..2770
FT /note="IQ 29"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2817..2848
FT /note="IQ 30"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2862..2893
FT /note="IQ 31"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2912..2941
FT /note="IQ 32"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2935..2966
FT /note="IQ 33"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2957..2988
FT /note="IQ 34"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 3032..3063
FT /note="IQ 35"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 3082..3113
FT /note="IQ 36"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 3206..3237
FT /note="IQ 37"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1057..1078
FT /evidence="ECO:0000255"
FT MOD_RES 280
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 283
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 367
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 392
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 425
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 605
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 1103
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
SQ SEQUENCE 3479 AA; 410106 MW; 589BA40F2D79BCC4 CRC64;
MANRRVGRGC WEVSPTERRP PAALRGPATE EEASSPPVLF LSHFCRSPFL CFGDVLLGDS
RTLPLALDNP NEEVAEVKIS HFPAADLGFS VSQRCFVLQP KEKIVISVNW TPFKEGRVRE
IMTFLVNDVL KHQAILLGNA EKQKKKKRSL WDTIKKKKIS ASTSHNRRVS NIQNVNKTFS
VSQKVDRVRS PLQACENLAM NEGGPPTENN SLTLEENKIP ISPISPAFNE CHGATCLPLS
VRRSTTYSSL HASENRELLN VDSANVSKVS FNEKAVTETS FNSINVNDQS GENSKLILTP
NYSSTLNITQ SQINFLSPDS FVNNSHGANN ELELVTCLSS DMFMTDNSKP VHLQSTTAHE
IYQKILSPDS FIKDNYGLNQ DLESESVNPI LSPNQFLKDN MAYMCTSQQT YKVPLSNENS
QVPQSPQDWS KSEVSPCIPE YQGSKSPKAI FEELVEMKSN YYSFIKQNNP KFSAVQDISS
HSHDKQPKRR PILSATVTKR KPTCTRENQT EINKPKAKRC LNSAVGEHEK VIHNQKEKED
FHSYLPVIDP VLSKSKSYKN QIMPSLTTAS VARKRKSDGS MEDANVRVAV TEHTEEREIK
RIHFSPSEPK TSAVKKTKNV ITPISKCISN REKLNLKKKT DLLIFKTPIS KTSKRTKPII
AVAQSNLTFI KPLKTDIPRH PMPFAAKNMF YDERWKEKQE QGFTWWLNFI LTPDDFTVKT
NISEVNAATL LLGVENQHKI SVPRAPTKEE MSLRAYTARC RLNRLRRAAC RLFTSEKMVK
AIKKLEIEIE ARRLIVRKDR HLWKDVGERQ KVLNWLLSYN PLWLRIGLET IYGELISLED
NSDVTGLAMF ILNRLLWNPD IAAEYRHPTV PHLYRDGHEG ALSKFTLKKL LLLICFLDYA
KISKLIDHDP CLFCKDAEFK ASKEILLAFS RDFLSGEGDL SRHLGLLGLP VNHVQTPFDE
FDFAITNLAV DLQCGVRLVR TMELLTQNWN LSKKLRIPAI SRLQKMHNVD IVLQVLKSRG
IELSDEHGNT ILSKDIVDRH REKTLRLLWK IAFAFQVDIS LNLDQLKEEI AFLKHTKSIK
KTISLLSCHS DALINKKKGK RDSGSFEQYS ENIKLLMDWV NAVCAFYNKK VENFTVSFSD
GRVLCYLIHH YHPCYVPFDA ICQRTTQTVE CTQTGSVVLN SSSESDDSSL DMSLKAFDHE
NTSELYKELL ENEKKNFQLI RSAVRDLGGI PAMINHSDMS NTIPDEKVVI TYLSFLCARL
LDLRKEIRAA RLIQTTWRKY KLKTDLKRHQ ERDKAARIIQ SAVINFLAKQ RLRKRVNAAL
IIQKYWRRVL AQRKLLILKK EKLEKVQNKA ASLIQGYWRR YSTRKRFLKL KYYSIILQSR
IRMIIAVTSY KRYLWATVTI QRHWRAYLRR KQDQQRYEML KSSSLIIQSM FRKWKRRKMQ
SQVKATVILQ RAFREWHLRK RAKEENSAIV IQSWYRMHKE LRKYIYIRSC VIVIQKRFRC
FQAQKLYKRK KESILTIQKY YKAYLKGKIE RTNYLQKRAA AIQLQAAFRR LKAHNLCRQI
RAACVIQSYW RMRQDRVRFL NLKKTIIKLQ AHIRKHQQLQ KYKKMKKAAV IIQTHFRAYI
FTRKVLASYQ KTRSAVIVLQ SAYRGMQARK VYIHILTSVI KIQSYYRAYV SKKEFLSLKN
TTIKLQSIVK MKQTRKQYLH LRAAALFIQQ CYRSKKITTQ KREEYMQMRE SCIKLQAFVR
GYLVRKQMRL QRKAVISLQS YFRMRKARQY YLKMCKAIMV IQNYYHAYKA QVNQRKNFLR
VKKAATCLQA AYRGYKVRQL IKQQSIAALK IQSAFRGYNK RVKYQSVLQS IIKIQRWYRA
YKTLHDTRTH FLKTKAAVVS LQSAYRGWKV RKQIRREHQA ALKIQSAFRM AKAQKQFRLF
KTAALVIQQN FRAWTAGRKQ RMEYIELRHA VLILQSMWKG KTLRRQLQRQ HKCAIIIQSY
YRMHVQQKKW KIMKKAALLI QKYYKAYSIG REQHHLYLKT KAAVVTLQSA YRGMKVRKRI
KDCNKAAVTI QSKYRAYKTK KKYATYRASA IIIQRWYRGI KITHRQHQEY LNLKKTAIKI
QSVYRGIRVR RHIQHMHRAA TFIKAMFKMH QSRISYHTMR KAAIVIQVRF RAYYQGKMHR
EKYLTILKAV KILQASFRGV RVRWTLRKMQ IAATLIQSNY RRYKQQTYFN KLKKITKTIQ
QRYRAVKERN IQFKRYNKLR HSVIYIQAIF RGKKARRHLK MMHVAATLIQ RRFRTLMMRR
RFLSLKKTAV WIQRKYRAHL CTKHHLQFLQ VQNAVIKIQS SYRRWMIRKK MREMHRAATF
IQATFRMHRV HMRYQALKQA SVVIQQQYRA NRAAKLQRQH YLRQRRSAVI LQAAFRGVKT
RRHLKSMHSS ATLIQSRFRS LLVRRRFISL KKATIFVQRK YRATICAKHK LHQFLQLRKA
AITIQSSYCT IRRLMVKKKL QEMQRAAVLI QATFRMHRTC VTFQTWKQAS ILIQQHYRTY
RAAKLQKENY IRQWHSAVVI QTAYKGMKAR QHLREKHKAA IIIQSTYRMY RQYCFYQKLQ
WATKIIQEKY RANKKKQKAL QHNELKKETC VQASFQDMNI QKQIQEQHQA AIIIQKHCKA
FKIRKHYLHL RATVVSIQRR YRKLTAVRTQ AVICIQSYYR GFKVRRDIQN MHRAATLIQS
FYRMHRAKVD YQTKKTAIVV IQNYYRLYVR VKTERKSFLP VQKSVRTIQA AFRGMKVRQK
LKIVSEEKMA AIVNQSALCC YRSKTQYEAV QSEGVMIQEW YKASDLACSQ EAECHSQSRA
AVTIQNAFRR MVTRKLETQK CAALRIQFFL QMAVYRRRFV QQKRAAITLQ HYFRTWQTRK
QFLLYRKAAV VLQNHYRAFL SAKHQRQVYL QIRSSVIIIQ ARSKGFIQKR KFQEIKNSTI
KIQAMWRRYR AKKYLCKVKA ACKIQAWYRC WRAHKEYLAI LKAVKIIQGC FYTKLERTWF
LNVRASAIII QRKWRAILSA KIAHEHFLMI KRHRAACLIQ AHYRGYKERQ VFLRQKSAAL
IIQKYIRARE AGKRERIKYI EFKKSTVILQ ALVRGWLVRK RILEQKTKIR LLHFTAAAYY
HLNALRIQRA YKLYLAVKNA NKQVNSVICI QRWFRARLQQ KKFIQKYSIK KIEHEGQECL
SQQNRAASVI QKAVRHFVLR KKQEKFTSGI IKIQALWRGY SWRKKNDCTK IKAIRLSLQV
VNREIREENK LYKRTALALH YLLTYKHLSA ILEALKHLEV VTRLSPLCCE NMAQSGAISK
IFVLIRSCNR SVPCMEVIRY AVQVLLNVSK YEKTTSAVYD VENCIDTLLE LLQIYREKPG
NKVADKGGSI FTKTCCLLAV LLKTTNRASD VRSRSKVVDR IYSLYKLTAH KHKMNTERIL
HKQKKNSSIS IPFIPETPVR TRIVSRLKPD WVLRRDNMEE ITNPLQAIQM VMDTLGIPY
