ID   PCYA_SYNP6              Reviewed;         248 AA.
AC   Q5N5A3;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Phycocyanobilin:ferredoxin oxidoreductase {ECO:0000255|HAMAP-Rule:MF_00618};
DE            EC=1.3.7.5 {ECO:0000255|HAMAP-Rule:MF_00618};
GN   Name=pcyA {ECO:0000255|HAMAP-Rule:MF_00618}; OrderedLocusNames=syc0325_d;
OS   Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis
OS   nidulans).
OC   Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus.
OX   NCBI_TaxID=269084;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27144 / PCC 6301 / SAUG 1402/1;
RX   PubMed=17211581; DOI=10.1007/s11120-006-9122-4;
RA   Sugita C., Ogata K., Shikata M., Jikuya H., Takano J., Furumichi M.,
RA   Kanehisa M., Omata T., Sugiura M., Sugita M.;
RT   "Complete nucleotide sequence of the freshwater unicellular cyanobacterium
RT   Synechococcus elongatus PCC 6301 chromosome: gene content and
RT   organization.";
RL   Photosyn. Res. 93:55-67(2007).
CC   -!- FUNCTION: Catalyzes the four-electron reduction of biliverdin IX-alpha
CC       (2-electron reduction at both the A and D rings); the reaction proceeds
CC       via an isolatable 2-electron intermediate, 181,182-dihydrobiliverdin.
CC       {ECO:0000255|HAMAP-Rule:MF_00618}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(2R,3Z)-phycocyanobilin + 4 oxidized [2Fe-2S]-[ferredoxin] =
CC         biliverdin IXalpha + 4 H(+) + 4 reduced [2Fe-2S]-[ferredoxin];
CC         Xref=Rhea:RHEA:15309, Rhea:RHEA-COMP:10000, Rhea:RHEA-COMP:10001,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738,
CC         ChEBI:CHEBI:57437, ChEBI:CHEBI:57991; EC=1.3.7.5;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00618};
CC   -!- SIMILARITY: Belongs to the HY2 family. {ECO:0000255|HAMAP-
CC       Rule:MF_00618}.
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DR   EMBL; AP008231; BAD78515.1; -; Genomic_DNA.
DR   RefSeq; WP_011242639.1; NC_006576.1.
DR   AlphaFoldDB; Q5N5A3; -.
DR   SMR; Q5N5A3; -.
DR   STRING; 269084.syc0325_d; -.
DR   EnsemblBacteria; BAD78515; BAD78515; syc0325_d.
DR   KEGG; syc:syc0325_d; -.
DR   eggNOG; ENOG502Z7RN; Bacteria.
DR   OMA; YQTPQFR; -.
DR   Proteomes; UP000001175; Chromosome.
DR   GO; GO:0050897; F:cobalt ion binding; IEA:InterPro.
DR   GO; GO:0050620; F:phycocyanobilin:ferredoxin oxidoreductase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0010024; P:phytochromobilin biosynthetic process; IEA:InterPro.
DR   HAMAP; MF_00618; Ferredoxin_bilin_red; 1.
DR   InterPro; IPR009249; Ferredoxin-dep_bilin_Rdtase.
DR   InterPro; IPR022870; Ferredoxin_bilin_OxRdtase.
DR   PANTHER; PTHR34557; PTHR34557; 1.
DR   Pfam; PF05996; Fe_bilin_red; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase.
FT   CHAIN           1..248
FT                   /note="Phycocyanobilin:ferredoxin oxidoreductase"
FT                   /id="PRO_1000061376"
SQ   SEQUENCE   248 AA;  28015 MW;  BC824F964B7E90B7 CRC64;
     MSSSTRVGLK EQLHPLIRDL ATGIEATWQR WLNLEPYAAM PADLGYIEGK LEGERLQIEN
     RCYQSREFRK LHLELARVGN NLDILHCVLF PRTTFDLPMF GADLVGGRGQ ISAAIVDLSP
     TTIARELSND YIAGLTALPN PTFQGLRELP TWGDIFSSFC LFIRPGSPEE EAAFLDRALG
     FLQVHCQQAA AATALTDPEA IATVLEQQRY YCEQQRRNDK TRRVLEKAFG DDWADRYMTT
     MLFDLPSD