ASPM_PANTR
ID ASPM_PANTR Reviewed; 3477 AA.
AC P62293;
DT 05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 23-FEB-2022, entry version 94.
DE RecName: Full=Abnormal spindle-like microcephaly-associated protein homolog;
GN Name=ASPM;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=14704186; DOI=10.1093/genetics/165.4.2063;
RA Zhang J.;
RT "Evolution of the human ASPM gene, a major determinant of brain size.";
RL Genetics 165:2063-2070(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=14722158; DOI=10.1093/hmg/ddh055;
RA Evans P.D., Anderson J.R., Vallender E.J., Gilbert S.L., Malcom C.M.,
RA Dorus S., Lahn B.T.;
RT "Adaptive evolution of ASPM, a major determinant of cerebral cortical size
RT in humans.";
RL Hum. Mol. Genet. 13:489-494(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND VARIANTS PHE-1744; ARG-1768
RP AND TYR-2811.
RX PubMed=15045028; DOI=10.1371/journal.pbio.0020126;
RA Kouprina N., Pavlicek A., Mochida G.H., Solomon G., Gersch W., Yoon Y.-H.,
RA Collura R., Ruvolo M., Barrett J.C., Woods C.G., Walsh C.A., Jurka J.,
RA Larionov V.;
RT "Accelerated evolution of the ASPM gene controlling brain size begins prior
RT to human brain expansion.";
RL PLoS Biol. 2:653-663(2004).
CC -!- FUNCTION: Probable role in mitotic spindle regulation and coordination
CC of mitotic processes. May have a preferential role in regulating
CC neurogenesis (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton,
CC spindle {ECO:0000250}. Nucleus {ECO:0000250}. Note=The nuclear-
CC cytoplasmic distribution could be regulated by the availability of
CC calmodulin. Localizes to spindle poles during mitosis (By similarity).
CC {ECO:0000250}.
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DR EMBL; AY367066; AAR12642.1; -; mRNA.
DR EMBL; AY488910; AAR84351.1; -; Genomic_DNA.
DR EMBL; AY488883; AAR84351.1; JOINED; Genomic_DNA.
DR EMBL; AY488884; AAR84351.1; JOINED; Genomic_DNA.
DR EMBL; AY488885; AAR84351.1; JOINED; Genomic_DNA.
DR EMBL; AY488886; AAR84351.1; JOINED; Genomic_DNA.
DR EMBL; AY488887; AAR84351.1; JOINED; Genomic_DNA.
DR EMBL; AY488888; AAR84351.1; JOINED; Genomic_DNA.
DR EMBL; AY488889; AAR84351.1; JOINED; Genomic_DNA.
DR EMBL; AY488890; AAR84351.1; JOINED; Genomic_DNA.
DR EMBL; AY488891; AAR84351.1; JOINED; Genomic_DNA.
DR EMBL; AY488892; AAR84351.1; JOINED; Genomic_DNA.
DR EMBL; AY488893; AAR84351.1; JOINED; Genomic_DNA.
DR EMBL; AY488894; AAR84351.1; JOINED; Genomic_DNA.
DR EMBL; AY488895; AAR84351.1; JOINED; Genomic_DNA.
DR EMBL; AY488896; AAR84351.1; JOINED; Genomic_DNA.
DR EMBL; AY488897; AAR84351.1; JOINED; Genomic_DNA.
DR EMBL; AY488898; AAR84351.1; JOINED; Genomic_DNA.
DR EMBL; AY488899; AAR84351.1; JOINED; Genomic_DNA.
DR EMBL; AY488900; AAR84351.1; JOINED; Genomic_DNA.
DR EMBL; AY488901; AAR84351.1; JOINED; Genomic_DNA.
DR EMBL; AY488902; AAR84351.1; JOINED; Genomic_DNA.
DR EMBL; AY488903; AAR84351.1; JOINED; Genomic_DNA.
DR EMBL; AY488904; AAR84351.1; JOINED; Genomic_DNA.
DR EMBL; AY488905; AAR84351.1; JOINED; Genomic_DNA.
DR EMBL; AY488906; AAR84351.1; JOINED; Genomic_DNA.
DR EMBL; AY488907; AAR84351.1; JOINED; Genomic_DNA.
DR EMBL; AY488908; AAR84351.1; JOINED; Genomic_DNA.
DR EMBL; AY488909; AAR84351.1; JOINED; Genomic_DNA.
DR EMBL; AY508452; AAS45487.1; -; mRNA.
DR EMBL; AY497016; AAS48534.1; -; Genomic_DNA.
DR RefSeq; NP_001008994.1; NM_001008994.1.
DR STRING; 9598.ENSPTRP00000051373; -.
DR PaxDb; P62293; -.
DR PRIDE; P62293; -.
DR GeneID; 449566; -.
DR KEGG; ptr:449566; -.
DR CTD; 259266; -.
DR eggNOG; KOG0165; Eukaryota.
DR InParanoid; P62293; -.
DR OrthoDB; 482623at2759; -.
DR Proteomes; UP000002277; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007051; P:spindle organization; IEA:InterPro.
DR Gene3D; 1.10.418.10; -; 2.
DR Gene3D; 1.25.10.10; -; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR031549; ASH.
DR InterPro; IPR029955; ASPM.
DR InterPro; IPR001715; CH-domain.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR22590:SF4; PTHR22590:SF4; 6.
DR Pfam; PF15780; ASH; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00612; IQ; 37.
DR SMART; SM00033; CH; 2.
DR SMART; SM00015; IQ; 64.
DR SUPFAM; SSF47576; SSF47576; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR SUPFAM; SSF52540; SSF52540; 19.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50096; IQ; 40.
PE 2: Evidence at transcript level;
KW Calmodulin-binding; Cell cycle; Cell division; Coiled coil; Cytoplasm;
KW Cytoskeleton; Mitosis; Nucleus; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..3477
FT /note="Abnormal spindle-like microcephaly-associated
FT protein homolog"
FT /id="PRO_0000191337"
FT DOMAIN 920..1056
FT /note="Calponin-homology (CH) 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT DOMAIN 1110..1261
FT /note="Calponin-homology (CH) 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT DOMAIN 1347..1378
FT /note="IQ 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1393..1422
FT /note="IQ 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1537..1568
FT /note="IQ 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1582..1613
FT /note="IQ 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1632..1661
FT /note="IQ 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1655..1684
FT /note="IQ 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1728..1757
FT /note="IQ 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1751..1782
FT /note="IQ 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1801..1830
FT /note="IQ 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1824..1853
FT /note="IQ 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1874..1903
FT /note="IQ 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1897..1928
FT /note="IQ 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1947..1978
FT /note="IQ 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1970..2001
FT /note="IQ 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2020..2049
FT /note="IQ 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2043..2074
FT /note="IQ 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2093..2124
FT /note="IQ 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2116..2147
FT /note="IQ 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2166..2197
FT /note="IQ 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2189..2218
FT /note="IQ 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2239..2270
FT /note="IQ 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2262..2293
FT /note="IQ 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2311..2342
FT /note="IQ 23"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2334..2365
FT /note="IQ 24"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2384..2415
FT /note="IQ 25"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2407..2438
FT /note="IQ 26"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2457..2488
FT /note="IQ 27"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2530..2561
FT /note="IQ 28"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2624..2653
FT /note="IQ 29"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2665..2696
FT /note="IQ 30"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2688..2719
FT /note="IQ 31"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2738..2767
FT /note="IQ 32"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2859..2890
FT /note="IQ 33"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2909..2938
FT /note="IQ 34"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2932..2963
FT /note="IQ 35"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2954..2985
FT /note="IQ 36"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 3029..3060
FT /note="IQ 37"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 3079..3110
FT /note="IQ 38"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 3181..3210
FT /note="IQ 39"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 3204..3235
FT /note="IQ 40"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 415..443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 559..583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1057..1078
FT /evidence="ECO:0000255"
FT COMPBIAS 559..574
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 280
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 283
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 367
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 392
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 425
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 605
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT VARIANT 1744
FT /note="V -> F"
FT /evidence="ECO:0000269|PubMed:15045028"
FT /id="VAR_019097"
FT VARIANT 1768
FT /note="Q -> R"
FT /evidence="ECO:0000269|PubMed:15045028"
FT /id="VAR_019098"
FT VARIANT 2811
FT /note="C -> Y"
FT /evidence="ECO:0000269|PubMed:15045028"
FT /id="VAR_019099"
FT CONFLICT 43..44
FT /note="HF -> RL (in Ref. 1; AAR12642)"
FT /evidence="ECO:0000305"
FT CONFLICT 231
FT /note="C -> Y (in Ref. 3; AAS48534)"
FT /evidence="ECO:0000305"
FT CONFLICT 864
FT /note="E -> K (in Ref. 1; AAR12642)"
FT /evidence="ECO:0000305"
FT CONFLICT 1078
FT /note="S -> G (in Ref. 1; AAR12642)"
FT /evidence="ECO:0000305"
FT CONFLICT 2288
FT /note="T -> A (in Ref. 1; AAR12642)"
FT /evidence="ECO:0000305"
FT CONFLICT 2375
FT /note="K -> T (in Ref. 3; AAS45487)"
FT /evidence="ECO:0000305"
FT CONFLICT 2452
FT /note="H -> Y (in Ref. 3; AAS45487)"
FT /evidence="ECO:0000305"
FT CONFLICT 2458
FT /note="R -> G (in Ref. 1; AAR12642)"
FT /evidence="ECO:0000305"
FT CONFLICT 2574
FT /note="Q -> R (in Ref. 3; AAS45487)"
FT /evidence="ECO:0000305"
FT CONFLICT 2667
FT /note="Q -> H (in Ref. 3; AAS45487)"
FT /evidence="ECO:0000305"
FT CONFLICT 2772
FT /note="Q -> K (in Ref. 3; AAS48534)"
FT /evidence="ECO:0000305"
FT CONFLICT 2978
FT /note="L -> S (in Ref. 1; AAR12642)"
FT /evidence="ECO:0000305"
FT CONFLICT 3196
FT /note="L -> V (in Ref. 3; AAS48534)"
FT /evidence="ECO:0000305"
FT CONFLICT 3367
FT /note="S -> T (in Ref. 3; AAS45487)"
FT /evidence="ECO:0000305"
FT CONFLICT 3376
FT /note="L -> S (in Ref. 1; AAR12642)"
FT /evidence="ECO:0000305"
FT CONFLICT 3427
FT /note="I -> V (in Ref. 1; AAR12642)"
FT /evidence="ECO:0000305"
FT CONFLICT 3461
FT /note="N -> Y (in Ref. 2; AAR84351)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 3477 AA; 409742 MW; 08297A71F92D3D03 CRC64;
MANRRVGRGC WEVSPTERRP PAGLRGPAAE EEASSPPVLS LSHFCRSPFL CFGDVLLGAS
RTLSLALDNP NEEVAEVKIS HFPAADLGFS VSQRCFVLQP KEKIVISVNW TPLKEGRVRE
IMTFLVNDVL KHQAILLGNA EEQKKKKRSL WDTIKKKKIS ASTSHNRRVS NIQNVNKTFS
VSQKVDRVRS PLQACENLAM NEGGPPTENN SLILEENKIP ISPISPAFNE CHGATCLPLS
VRRSTTYSSL HASENRELLN VHSANVSKVS FNEKAVTETS FNSVNVNGQS GENSKLSLTP
NYSSTLNITQ SQTHFLSPDS FVNNSHGANN ELELVTCLSS DMFMKDNSKP VHLESTIAHE
IYQKILSPDS FIKDNYGLNQ DLESESVNPI LSPNQFLKDN MAYMCTSQQT CKVPLSNENS
QVPQSPEDWR KSEVSPRIPE CQGSKSPKAI FEELVEMKSN YYSFIKQNNP KFSAVQDISS
HSHNKQPKRR PILSATVTKR KATCTRENQT EINKPKAKRC LNSAVGEHEK VINNQKEKED
FHSYLPIIDP ILSKSKSYKN EVTPSSTTAS VARKRKSDGS MEDGNVRVAI TEHTEVREIK
RIHFSPSEPK TSAVKKTKNV ITPISKRISN REKLNLKKKT DLSIFRTPIS KTNKRTKPII
AVAQSSLTFI KPLKTDIPRH PMPFAAKNMF YDERWKEKQE QGFTWWLNFI LTPDDFTVKT
NISEVNAATL LLGIENQHKI SVPRAPTKEE MSLRAYTARC RLNRLRRAAC RLFTSEKMVK
AIKKLEIEIE ARRLIVRKDR HLWKDVGERQ KVLNWLLSYN PLWLRIGLET TYGELISLED
NSDVTGLAMF ILNRLLWNPD IAAEYRHPSV PHLYRDGHEE VLSKFTLKKL LLLVCFLDYA
KISRLIDHDP CLFCKDAEFK ASKEILLAFS RDFLSGEGDL SRHLGLLGLP VNHVQTPFDE
FDFAVTNLAV DLQCGVRLVR TMELLTQNWD LSKKLRIPAI SRLQKMHNVD IVLQVLKSRG
IELSDEHGNT ILSKDIVDRH REKTLRLLWK IAFAFQVDIS LNLDQLKEEI AFLKHTKSIK
KTISLLSCHS DDLINKKKGK RDCGSFEQYS ENIKLLMDWV NAVCAFYNKK VENFTVSFSD
GRVLCYLIHH YHPCYVPFDA ICQRTTQTVE CTQTGSVVLN SSSESDDSSL DMSLKAFDHE
NTSELYKELL ENEKKNFHLV RSAVRDLGGI PAMINHSDMS NTIPDEKVVI TYLSFLCARL
LDLRKEIRAA RLIQTTWRKY KLKTDLKRHQ EREKAARIIQ LAVINFLAKQ RLRKRVNAAL
VIQKYWRRVL AQRKLLMLKK EKLEKVQNKA ASLIQGYWRR YSTRQRFLKL KYYSIILQSR
IRMIIAVTSY KRYLWATVTI QRHWRAYLRR KQDQQRYEML KSSTLIIQSM FRKWKQRKMQ
SQVKATVILQ RAFREWHLRK QAKEQNSAII IQSWYRMHKE LRKYIYIRSC VVIIQKRFRC
FQAQKLYKRK KESILTIQKY YKAYLKGKIE RTNYLQKRAA AIQLQAAFRR LKAHNLYRQI
RAACVIQSYW RMRQDRVRFL NLKKTIIKLQ AHVRKHQQRQ KYKKMKKAAV IIQTHFRAYI
FAMKVLASYQ KIRSAVIVLQ SAYRGMQARK MYIHILTSVI KIQSYYRAYV SKKEFLSLKN
ATIKLQSIVK MKQTRKQYLH LRAAALFIQQ CYRSKKIAAQ KREEYMQMRE SCIKLQAFVR
GYLVRKQMRL RRKAVISLQS YFRMRKAQQY YLKMYKAIIV IQNYYHAYKA QVNQRKNFLQ
VKKAATCLQA AYRGYKVRQL IKQQSIAALK IQSAFRGYNK RVKYQSVLQS IIKIQRWYRA
YKTLHDTRTH FLKTKAAVIS LQSAYRGWKV RKQIRREHQA ALKIQSAFRM AKAQKQFRLF
KTAALVIQQN FRAWTAGRKQ RMEYIELRHA VLMLQSMWKG KTLRRQLQRQ HKCAIIIQSY
YRMHVQQKKW KIMKKAALLI QKYYRAYSIG REQNHLYLKT KAAVVTLQSA YRGMKVRKRI
KDCNKAAVTI QSKYRAYKTK KKYATYRASA IIIQRWYRGI KITNHQHKEY LNLKKTAIKI
QSVYRGIRVR RHIQHMHRAA TFIKAMFKMH QSRISYHTMR KAAIVIQVRC RAYYQGKMQR
EKYLTILKAV KVLQASFRGV RVRRTLRKMQ IAATLIQSNY RRYRQQTYFN KLKKITKTVQ
QRYRAMKERN IQFQRYNKLR HSVIYIQAIF RGKKARRHLK MMHIAATLIQ RRFRTLMMRR
RFLSLKKTAI LIQRKYRAHL CTKHHLQFLQ VQNAVIKIQS SYRRWMIRKR MREMHRAATF
IQATFRMHRL HMRYQALKQA SVVIQQQYQA NRAAKLQRQH YLRQRHSAVI LQAAFRGMKT
RRHLKSMHSS ATLIQSRFRS LLVRRRFISL KKATIFVQRK YRATICAKHK LHQFLHLRKA
AITIQSSYRR LMVKKKLQEM QRAAVLIQAT FRMHRTYITF QTWKHASILI QQHYRTYRAA
KLRRENYIRQ WHSAVVIQAA YKGMKARQLL REKHKASIII QSTYRMYRQY CFYQKLQWAT
KIIQEKYRAN KKKQKAFQHN ELKKETCVQA GFQDMNIKKQ IQEQHQAAII IQKHCKAFKI
RKHYLHLRAT VVSIQRRYRK LTAVRTQAVI CIQSYYRGFK VRKDIQNMHR AATLIQSFYR
MHRAKVDYET KKTAVVVIQN YYRLYVRVKT ERKNFLAVQK SVRTIQAAFR GMKVRQKLKN
VSEEKMAAIV NQSALCCYRS KTQYEAVQSE GVMIQEWYKA SGLACSQEAE CHSQSRAAVT
IQKAFCRMVT RKLETQKCAA LRIQFFLQMA VYRRRFVQQK RAAITLQHYF RTWQTRKQFL
LYRKAAVVLQ NHYRAFLSAK HQRQVYLQIR SSVIIIQARS KGFIQKRKFQ EIKNSTIKIQ
AMWRRYRAKK YLCKVKAACK IQAWYRCWRA HKEYLAILKA VKIIQGCFYT KLERTRFLNV
RASAIIIQRK WRAILSAKIA HEHFLMIKRH RAACLIQAHY RGYKGRQVFL RQKSAALIIQ
KYIRAREAGK RERIKYIEFK KSTVILQALV RGWLVRKRIL EQRAKIRLLH FTAAAYYHLN
AVRIQRAYKL YLAVKNANKQ VNSVICIQRW FRARLQEKRF IQKYHSIKKI EHEGQECLSQ
RNRAASVIQK AVRHFLLRKK QEKFTSGIIK IQALWRGYSW RKKNDCTKIK AIRLSLQVVN
REIREENKLY KRTALALHYL LTYKHLSAIL EALKHLEVVT RLSPLCCENM AQSGAISKIF
VLIRSCNRSI PCMEVIRYAV QVLLNVSKYE KTTSAVYDVE NCIDILLELL QIYREKPGNK
VADKGGSIFT KTCCLLAILL KTTNRASDVR SRSKVVDRIY SLYKLTAHKH KMNTERILYK
QKKNSSISIP FIPETPVRTR IVSRLKPDWV LRRDNMEEIT NPLQAIQMVM DTLGIPY
