PCYXL_MOUSE
ID PCYXL_MOUSE Reviewed; 495 AA.
AC Q8C7K6;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Prenylcysteine oxidase-like;
DE EC=1.8.3.-;
DE Flags: Precursor;
GN Name=Pcyox1l;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Hippocampus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Lung, Pancreas, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Probable oxidoreductase. {ECO:0000250}.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the prenylcysteine oxidase family.
CC {ECO:0000305}.
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DR EMBL; AK050006; BAC34029.1; -; mRNA.
DR EMBL; BC060677; AAH60677.1; -; mRNA.
DR CCDS; CCDS29287.1; -.
DR RefSeq; NP_766420.1; NM_172832.4.
DR AlphaFoldDB; Q8C7K6; -.
DR STRING; 10090.ENSMUSP00000025472; -.
DR GlyConnect; 2602; 1 N-Linked glycan (1 site).
DR GlyGen; Q8C7K6; 2 sites, 1 N-linked glycan (1 site).
DR iPTMnet; Q8C7K6; -.
DR PhosphoSitePlus; Q8C7K6; -.
DR EPD; Q8C7K6; -.
DR MaxQB; Q8C7K6; -.
DR PaxDb; Q8C7K6; -.
DR PeptideAtlas; Q8C7K6; -.
DR PRIDE; Q8C7K6; -.
DR ProteomicsDB; 287801; -.
DR Antibodypedia; 27814; 78 antibodies from 18 providers.
DR Ensembl; ENSMUST00000025472; ENSMUSP00000025472; ENSMUSG00000024579.
DR GeneID; 240334; -.
DR KEGG; mmu:240334; -.
DR UCSC; uc008fcm.1; mouse.
DR CTD; 78991; -.
DR MGI; MGI:3606062; Pcyox1l.
DR VEuPathDB; HostDB:ENSMUSG00000024579; -.
DR eggNOG; ENOG502QSHJ; Eukaryota.
DR GeneTree; ENSGT00390000011206; -.
DR HOGENOM; CLU_021176_1_0_1; -.
DR InParanoid; Q8C7K6; -.
DR OMA; NLWSVEG; -.
DR OrthoDB; 1114069at2759; -.
DR PhylomeDB; Q8C7K6; -.
DR TreeFam; TF329001; -.
DR Reactome; R-MMU-114608; Platelet degranulation.
DR BioGRID-ORCS; 240334; 2 hits in 74 CRISPR screens.
DR ChiTaRS; Pcyox1l; mouse.
DR PRO; PR:Q8C7K6; -.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; Q8C7K6; protein.
DR Bgee; ENSMUSG00000024579; Expressed in lumbar dorsal root ganglion and 116 other tissues.
DR ExpressionAtlas; Q8C7K6; baseline and differential.
DR Genevisible; Q8C7K6; MM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0001735; F:prenylcysteine oxidase activity; IBA:GO_Central.
DR GO; GO:0030327; P:prenylated protein catabolic process; IBA:GO_Central.
DR GO; GO:0030328; P:prenylcysteine catabolic process; IEA:InterPro.
DR Gene3D; 3.50.50.60; -; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR010795; Prenylcys_lyase.
DR InterPro; IPR017046; Prenylcysteine_Oxase.
DR PANTHER; PTHR15944; PTHR15944; 1.
DR Pfam; PF07156; Prenylcys_lyase; 1.
DR PIRSF; PIRSF036292; Prenylcysteine_oxidase; 1.
DR SUPFAM; SSF51905; SSF51905; 1.
PE 1: Evidence at protein level;
KW FAD; Flavoprotein; Glycoprotein; Oxidoreductase; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000250"
FT CHAIN 23..495
FT /note="Prenylcysteine oxidase-like"
FT /id="PRO_0000280287"
FT CARBOHYD 185
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 343
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 495 AA; 54875 MW; DA86F56E6B108198 CRC64;
MARAAPLLAV LATVLTTAAA GGDAPPGKIA VIGAGIGGSA VAHFLQQHFG PRVQIVVYEK
GTVGGRLATI SVNKQNYESG AASFHSLSLH MQDFVKLLGL RQRREVVGRS AIFGGEHFVL
EETDWYLLNL FRLWWYYGIS FLRLQMWVEE VMEKFMRIYK YQAHGYAFSG VEELLYSLGE
ATFVNMTQRS VAESLLQVGV TQRFIDDVVS AVLRASYGQS ASMPAFAGAM SLAGAQGNLW
SVEGGNKLVC SGLLKLAKAT VIHATVTSVT LHSTEGKALY QVAYESDKGN SSDFYDIVVI
ATPLHLDNSS NNNITFEGFT PPIEDIQGSF QPTVVSLVHG YLNSSYFGFP DPKLFPFANI
LTTDFPSFFC TLDNICPVNI SASFRRKQPQ EAAVWRVQSP KPLFRTELKT LFRSYYSVQT
AEWQAHPLYG SRRTLPRFAL HDQLFYLNAL EWAASSVEVT AVAAKNVALL AYNRWYQDLD
KIDQKDLIHK VKTEL
