PD10A_DANRE
ID PD10A_DANRE Reviewed; 210 AA.
AC Q6PHH3; A8DZ91;
DT 11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Programmed cell death protein 10-A;
GN Name=pdcd10a; Synonyms=pdcd10; ORFNames=si:ch211-167c22.5;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP INTERACTION WITH CCM2; STK25 AND STK26, AND FUNCTION.
RX PubMed=19370760; DOI=10.1002/humu.20996;
RA Voss K., Stahl S., Hogan B.M., Reinders J., Schleider E.,
RA Schulte-Merker S., Felbor U.;
RT "Functional analyses of human and zebrafish 18-amino acid in-frame deletion
RT pave the way for domain mapping of the cerebral cavernous malformation 3
RT protein.";
RL Hum. Mutat. 30:1003-1011(2009).
CC -!- FUNCTION: Promotes cell proliferation. Modulates apoptotic pathways.
CC Increases mitogen-activated protein kinase activity. Important for cell
CC migration, and for normal structure and assembly of the Golgi complex.
CC Important for KDR/VEGFR2 signaling. Required for normal angiogenesis,
CC vasculogenesis and hematopoiesis during embryonic development (By
CC similarity). Required for normal cardiovascular development
CC (PubMed:19370760). {ECO:0000250|UniProtKB:Q8VE70,
CC ECO:0000250|UniProtKB:Q9BUL8, ECO:0000269|PubMed:19370760}.
CC -!- SUBUNIT: Interacts (via C-terminus) with CCM2. Interacts (via N-
CC terminus) with STK25 and STK26. {ECO:0000269|PubMed:19370760}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Golgi apparatus membrane
CC {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC side {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane
CC protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the PDCD10 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH56552.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AL845366; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC056552; AAH56552.1; ALT_INIT; mRNA.
DR RefSeq; NP_956849.2; NM_200555.2.
DR RefSeq; XP_005159037.1; XM_005158980.3.
DR AlphaFoldDB; Q6PHH3; -.
DR SMR; Q6PHH3; -.
DR STRING; 7955.ENSDARP00000046901; -.
DR PaxDb; Q6PHH3; -.
DR Ensembl; ENSDART00000046902; ENSDARP00000046901; ENSDARG00000035054.
DR Ensembl; ENSDART00000188091; ENSDARP00000156496; ENSDARG00000035054.
DR Ensembl; ENSDART00000190699; ENSDARP00000150771; ENSDARG00000109378.
DR GeneID; 393527; -.
DR KEGG; dre:393527; -.
DR CTD; 393527; -.
DR ZFIN; ZDB-GENE-040426-1432; pdcd10a.
DR eggNOG; KOG4025; Eukaryota.
DR GeneTree; ENSGT00390000017913; -.
DR HOGENOM; CLU_083906_1_0_1; -.
DR InParanoid; Q6PHH3; -.
DR OMA; HVVLFPI; -.
DR OrthoDB; 1507394at2759; -.
DR PhylomeDB; Q6PHH3; -.
DR TreeFam; TF105802; -.
DR PRO; PR:Q6PHH3; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 18.
DR Bgee; ENSDARG00000035054; Expressed in intestine and 28 other tissues.
DR GO; GO:0090443; C:FAR/SIN/STRIPAK complex; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0001568; P:blood vessel development; IMP:ZFIN.
DR GO; GO:0048514; P:blood vessel morphogenesis; IGI:ZFIN.
DR GO; GO:0043009; P:chordate embryonic development; IGI:ZFIN.
DR GO; GO:0007507; P:heart development; IGI:ZFIN.
DR GO; GO:0003007; P:heart morphogenesis; IGI:ZFIN.
DR GO; GO:0043406; P:positive regulation of MAP kinase activity; IBA:GO_Central.
DR GO; GO:1903358; P:regulation of Golgi organization; IBA:GO_Central.
DR GO; GO:0001944; P:vasculature development; IGI:ZFIN.
DR Gene3D; 1.10.12.70; -; 1.
DR InterPro; IPR046409; PDC10_dimerisation_sf.
DR InterPro; IPR009652; PDCD10.
DR PANTHER; PTHR13250; PTHR13250; 1.
PE 1: Evidence at protein level;
KW Angiogenesis; Apoptosis; Cell membrane; Cytoplasm; Golgi apparatus;
KW Membrane; Reference proteome.
FT CHAIN 1..210
FT /note="Programmed cell death protein 10-A"
FT /id="PRO_0000187566"
SQ SEQUENCE 210 AA; 24380 MW; AFD8987AC7F12891 CRC64;
MTMEEMKNEA DATSMVSMTL YAVMYPVFNE LESVNLSAAQ TLRAAFKKAE KENPGLTQDI
IMKILEKKNV EINFTESLLR MAADDVEEYM IDRPEREFQD LNERARALKQ ILSKIPDEIN
DRVRFLQTIK DIASAIKELL DTVNNVFKKY QYQNRRALEH QKKEFVKHSK SFSDTLKTYF
KDGKAINVFA SANRLIHQTN LILQTFKTVA
