ID   PD10B_DANRE             Reviewed;         210 AA.
AC   Q6NWL1;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Programmed cell death protein 10-B;
GN   Name=pdcd10b {ECO:0000312|ZFIN:ZDB-GENE-040426-2607}; ORFNames=zgc:85629;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1] {ECO:0000312|EMBL:AAH67550.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney {ECO:0000312|EMBL:AAH67550.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   INTERACTION WITH CCM2; STK25 AND STK26, AND FUNCTION.
RX   PubMed=19370760; DOI=10.1002/humu.20996;
RA   Voss K., Stahl S., Hogan B.M., Reinders J., Schleider E.,
RA   Schulte-Merker S., Felbor U.;
RT   "Functional analyses of human and zebrafish 18-amino acid in-frame deletion
RT   pave the way for domain mapping of the cerebral cavernous malformation 3
RT   protein.";
RL   Hum. Mutat. 30:1003-1011(2009).
CC   -!- FUNCTION: Promotes cell proliferation. Modulates apoptotic pathways.
CC       Increases mitogen-activated protein kinase activity. Important for cell
CC       migration, and for normal structure and assembly of the Golgi complex.
CC       Important for KDR/VEGFR2 signaling. Required for normal angiogenesis,
CC       vasculogenesis and hematopoiesis during embryonic development (By
CC       similarity). Required for normal cardiovascular development
CC       (PubMed:19370760). {ECO:0000250|UniProtKB:Q8VE70,
CC       ECO:0000250|UniProtKB:Q9BUL8, ECO:0000269|PubMed:19370760}.
CC   -!- SUBUNIT: Interacts (via C-terminus) with CCM2. Interacts (via N-
CC       terminus) with STK25 and STK26. {ECO:0000269|PubMed:19370760}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Golgi apparatus membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC       side {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane
CC       protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PDCD10 family. {ECO:0000255}.
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DR   EMBL; BC067550; AAH67550.1; -; mRNA.
DR   RefSeq; NP_998098.1; NM_212933.1.
DR   AlphaFoldDB; Q6NWL1; -.
DR   SMR; Q6NWL1; -.
DR   STRING; 7955.ENSDARP00000021450; -.
DR   PaxDb; Q6NWL1; -.
DR   PRIDE; Q6NWL1; -.
DR   DNASU; 405869; -.
DR   GeneID; 405869; -.
DR   KEGG; dre:405869; -.
DR   CTD; 405869; -.
DR   ZFIN; ZDB-GENE-040426-2607; pdcd10b.
DR   eggNOG; KOG4025; Eukaryota.
DR   InParanoid; Q6NWL1; -.
DR   OrthoDB; 1507394at2759; -.
DR   PhylomeDB; Q6NWL1; -.
DR   PRO; PR:Q6NWL1; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0090443; C:FAR/SIN/STRIPAK complex; IBA:GO_Central.
DR   GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR   GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0001568; P:blood vessel development; IMP:ZFIN.
DR   GO; GO:0048514; P:blood vessel morphogenesis; IGI:ZFIN.
DR   GO; GO:0043009; P:chordate embryonic development; IMP:ZFIN.
DR   GO; GO:0007507; P:heart development; IGI:ZFIN.
DR   GO; GO:0003007; P:heart morphogenesis; IGI:ZFIN.
DR   GO; GO:0043406; P:positive regulation of MAP kinase activity; IBA:GO_Central.
DR   GO; GO:1903358; P:regulation of Golgi organization; IBA:GO_Central.
DR   GO; GO:0001944; P:vasculature development; IGI:ZFIN.
DR   Gene3D; 1.10.12.70; -; 1.
DR   InterPro; IPR046409; PDC10_dimerisation_sf.
DR   InterPro; IPR009652; PDCD10.
DR   PANTHER; PTHR13250; PTHR13250; 1.
PE   1: Evidence at protein level;
KW   Angiogenesis; Apoptosis; Cell membrane; Cytoplasm; Golgi apparatus;
KW   Membrane; Reference proteome.
FT   CHAIN           1..210
FT                   /note="Programmed cell death protein 10-B"
FT                   /id="PRO_0000320548"
SQ   SEQUENCE   210 AA;  24425 MW;  1FDD3B9D631D59C4 CRC64;
     MTMEEMKNEA EPNSIVSMTL YAVMYPVFNE LGRINPSAAQ TLRAAFVKAE KENPGLTQDI
     IMKILEKKNV EINFTESLLR MAADDVEEYL IKRPEQEFQD LNEKARALKH ILSKIPDEIN
     DRVRFLQTIK DIASAIKELL DTVNNVFRKY QYQNRRALEH QKKEFVKYSK SFSDTLKTYF
     KDGKAINVFI SANRLIHQTN LILQTFKTVA