ASPM_PONPY
ID ASPM_PONPY Reviewed; 3471 AA.
AC P62294;
DT 05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 23-FEB-2022, entry version 84.
DE RecName: Full=Abnormal spindle-like microcephaly-associated protein homolog;
GN Name=ASPM;
OS Pongo pygmaeus (Bornean orangutan).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9600;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=14704186; DOI=10.1093/genetics/165.4.2063;
RA Zhang J.;
RT "Evolution of the human ASPM gene, a major determinant of brain size.";
RL Genetics 165:2063-2070(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=14722158; DOI=10.1093/hmg/ddh055;
RA Evans P.D., Anderson J.R., Vallender E.J., Gilbert S.L., Malcom C.M.,
RA Dorus S., Lahn B.T.;
RT "Adaptive evolution of ASPM, a major determinant of cerebral cortical size
RT in humans.";
RL Hum. Mol. Genet. 13:489-494(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=15045028; DOI=10.1371/journal.pbio.0020126;
RA Kouprina N., Pavlicek A., Mochida G.H., Solomon G., Gersch W., Yoon Y.-H.,
RA Collura R., Ruvolo M., Barrett J.C., Woods C.G., Walsh C.A., Jurka J.,
RA Larionov V.;
RT "Accelerated evolution of the ASPM gene controlling brain size begins prior
RT to human brain expansion.";
RL PLoS Biol. 2:653-663(2004).
CC -!- FUNCTION: Probable role in mitotic spindle regulation and coordination
CC of mitotic processes. May have a preferential role in regulating
CC neurogenesis (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton,
CC spindle {ECO:0000250}. Nucleus {ECO:0000250}. Note=The nuclear-
CC cytoplasmic distribution could be regulated by the availability of
CC calmodulin. Localizes to spindle poles during mitosis (By similarity).
CC {ECO:0000250}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY367067; AAR12643.1; -; mRNA.
DR EMBL; AY488966; AAR84353.1; -; Genomic_DNA.
DR EMBL; AY488939; AAR84353.1; JOINED; Genomic_DNA.
DR EMBL; AY488940; AAR84353.1; JOINED; Genomic_DNA.
DR EMBL; AY488941; AAR84353.1; JOINED; Genomic_DNA.
DR EMBL; AY488942; AAR84353.1; JOINED; Genomic_DNA.
DR EMBL; AY488943; AAR84353.1; JOINED; Genomic_DNA.
DR EMBL; AY488944; AAR84353.1; JOINED; Genomic_DNA.
DR EMBL; AY488945; AAR84353.1; JOINED; Genomic_DNA.
DR EMBL; AY488946; AAR84353.1; JOINED; Genomic_DNA.
DR EMBL; AY488947; AAR84353.1; JOINED; Genomic_DNA.
DR EMBL; AY488948; AAR84353.1; JOINED; Genomic_DNA.
DR EMBL; AY488949; AAR84353.1; JOINED; Genomic_DNA.
DR EMBL; AY488950; AAR84353.1; JOINED; Genomic_DNA.
DR EMBL; AY488951; AAR84353.1; JOINED; Genomic_DNA.
DR EMBL; AY488952; AAR84353.1; JOINED; Genomic_DNA.
DR EMBL; AY488953; AAR84353.1; JOINED; Genomic_DNA.
DR EMBL; AY488954; AAR84353.1; JOINED; Genomic_DNA.
DR EMBL; AY488955; AAR84353.1; JOINED; Genomic_DNA.
DR EMBL; AY488956; AAR84353.1; JOINED; Genomic_DNA.
DR EMBL; AY488957; AAR84353.1; JOINED; Genomic_DNA.
DR EMBL; AY488958; AAR84353.1; JOINED; Genomic_DNA.
DR EMBL; AY488959; AAR84353.1; JOINED; Genomic_DNA.
DR EMBL; AY488960; AAR84353.1; JOINED; Genomic_DNA.
DR EMBL; AY488961; AAR84353.1; JOINED; Genomic_DNA.
DR EMBL; AY488962; AAR84353.1; JOINED; Genomic_DNA.
DR EMBL; AY488963; AAR84353.1; JOINED; Genomic_DNA.
DR EMBL; AY488964; AAR84353.1; JOINED; Genomic_DNA.
DR EMBL; AY488965; AAR84353.1; JOINED; Genomic_DNA.
DR EMBL; AY497017; AAS48532.1; -; Genomic_DNA.
DR SMR; P62294; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007051; P:spindle organization; IEA:InterPro.
DR Gene3D; 1.10.418.10; -; 2.
DR Gene3D; 1.25.10.10; -; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR031549; ASH.
DR InterPro; IPR029955; ASPM.
DR InterPro; IPR001715; CH-domain.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR22590:SF4; PTHR22590:SF4; 6.
DR Pfam; PF15780; ASH; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00612; IQ; 36.
DR SMART; SM00033; CH; 2.
DR SMART; SM00015; IQ; 65.
DR SUPFAM; SSF47576; SSF47576; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR SUPFAM; SSF52540; SSF52540; 16.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50096; IQ; 39.
PE 2: Evidence at transcript level;
KW Calmodulin-binding; Cell cycle; Cell division; Coiled coil; Cytoplasm;
KW Cytoskeleton; Mitosis; Nucleus; Phosphoprotein; Repeat.
FT CHAIN 1..3471
FT /note="Abnormal spindle-like microcephaly-associated
FT protein homolog"
FT /id="PRO_0000191338"
FT DOMAIN 914..1050
FT /note="Calponin-homology (CH) 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT DOMAIN 1104..1255
FT /note="Calponin-homology (CH) 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT DOMAIN 1341..1372
FT /note="IQ 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1387..1416
FT /note="IQ 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1576..1607
FT /note="IQ 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1599..1628
FT /note="IQ 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1626..1655
FT /note="IQ 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1649..1678
FT /note="IQ 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1722..1751
FT /note="IQ 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1745..1776
FT /note="IQ 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1795..1824
FT /note="IQ 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1818..1847
FT /note="IQ 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1868..1897
FT /note="IQ 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1891..1922
FT /note="IQ 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1941..1972
FT /note="IQ 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1964..1995
FT /note="IQ 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2014..2043
FT /note="IQ 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2037..2068
FT /note="IQ 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2087..2118
FT /note="IQ 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2110..2141
FT /note="IQ 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2160..2191
FT /note="IQ 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2183..2212
FT /note="IQ 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2233..2264
FT /note="IQ 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2256..2287
FT /note="IQ 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2305..2336
FT /note="IQ 23"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2378..2409
FT /note="IQ 24"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2401..2432
FT /note="IQ 25"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2451..2482
FT /note="IQ 26"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2524..2555
FT /note="IQ 27"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2659..2690
FT /note="IQ 28"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2682..2713
FT /note="IQ 29"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2732..2761
FT /note="IQ 30"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2853..2884
FT /note="IQ 31"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2903..2932
FT /note="IQ 32"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2926..2957
FT /note="IQ 33"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2948..2979
FT /note="IQ 34"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 3023..3054
FT /note="IQ 35"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 3073..3104
FT /note="IQ 36"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 3134..3163
FT /note="IQ 37"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 3175..3204
FT /note="IQ 38"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 3198..3229
FT /note="IQ 39"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 555..576
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1051..1072
FT /evidence="ECO:0000255"
FT MOD_RES 274
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 277
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 361
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 386
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 419
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 599
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 1097
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT CONFLICT 150
FT /note="K -> R (in Ref. 1; AAR12643)"
FT /evidence="ECO:0000305"
FT CONFLICT 303
FT /note="T -> S (in Ref. 3; AAS48532)"
FT /evidence="ECO:0000305"
FT CONFLICT 350
FT /note="Missing (in Ref. 3; AAS48532)"
FT /evidence="ECO:0000305"
FT CONFLICT 710
FT /note="F -> L (in Ref. 1; AAR12643)"
FT /evidence="ECO:0000305"
FT CONFLICT 772
FT /note="M -> I (in Ref. 3; AAS48532)"
FT /evidence="ECO:0000305"
FT CONFLICT 1607
FT /note="Q -> R (in Ref. 1; AAR12643)"
FT /evidence="ECO:0000305"
FT CONFLICT 2398
FT /note="L -> S (in Ref. 1; AAR12643)"
FT /evidence="ECO:0000305"
FT CONFLICT 2454
FT /note="S -> A (in Ref. 2; AAR84353)"
FT /evidence="ECO:0000305"
FT CONFLICT 2471
FT /note="L -> S (in Ref. 1; AAR12643)"
FT /evidence="ECO:0000305"
FT CONFLICT 2490
FT /note="T -> A (in Ref. 1; AAR12643)"
FT /evidence="ECO:0000305"
FT CONFLICT 2936
FT /note="I -> M (in Ref. 1; AAR12643)"
FT /evidence="ECO:0000305"
FT CONFLICT 3000
FT /note="I -> T (in Ref. 3; AAS48532)"
FT /evidence="ECO:0000305"
FT CONFLICT 3045
FT /note="R -> Q (in Ref. 3; AAS48532)"
FT /evidence="ECO:0000305"
FT CONFLICT 3196
FT /note="E -> G (in Ref. 1; AAR12643)"
FT /evidence="ECO:0000305"
FT CONFLICT 3268
FT /note="K -> R (in Ref. 1; AAR12643)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 3471 AA; 409369 MW; 0FB9E2902D8E8B4A CRC64;
MANRRVGRGC WEVSPTERRP PAAEEEASSP PVLSLSHFCR SPFLCFGDVL LGASRTLSLA
LDNPNEEVAE VKISHFPAAD LGFSVSQRCF VLQPKEKIVI SVNWTPFKEG RVREIMTFLV
NDVLKHQAIL LGNAEEQKKK KRSLWDTIKK KKISASTSHN RRVSNIQNVN KTFSVSQKVD
RVRSPLQACE NLAMNEGGPP TENNSLTLEG NKIPISPISP AFNECHGETC LPLSVRRSTT
YSSLHASENR ELLNVDSASV SKVSFNEKAV TETSFNSINV NGQSGENSKL SLTPNYSSTL
NITQSQIHFL SPDSFVNNSH GANNELELVT CLSSDMFMKD NSKPVHLEST IAHEIYQKIL
SPDSFIKDNY GLNQDVESES VNPILSPNQF LKDNMAYMCT SQQTCKVPLS NENSQVPQSP
QDWRKSEVLP RIPECQGSKS PKAIFEELVE MKSNYYSFIK QNNPKFSVVQ DISSHSHNKQ
PKRRPILSAT VTKRKATCTR ENQTEINKPK AKRCLNSAVG EHEKVINNQK EKEDFHSYLP
IIDPILSKSK SYKNEVTPSS TTASVARKRK SDGSMEDADV RVAVTEHTEV REIKRIHFSP
SEPKTSAVKK TKNVITPISK RISNREKLNL KKKTDLSIFK TPISKTNKRT KPIIAVAQSN
LTFIKPLKTD IPRHPMPFAA KNMFYDERWK EKQEQGFTWW LNFILTPDDF TVKTNISEVN
AATLLLGIEN QHKISVPRAP TKEEMSLRAY TARCRLNRLR RAACRLFTSE KMIKAIKKLE
IEIEARRLIV RKDRHLWKDV GERQKVLNWL LSYNPLWLRI GLETTYGELI SLEDNSDVTG
LAMFILNRLL WNPDIAAEYR HPTVPHLYRD GHEEALSKFT LKKLLLLVCF LDYAKISRLI
DHDPCLFCKD AEFKASKEIL LAFSRDFLSG EGDLSRHLGL LGLPVNHVQT PFDEFDFAVT
NLAVDLQCGV RLVRTMELLT QNWDLSKKLR IPAISRLQKM HNVDIVLQVL KSRGIELSDE
HGNTILSKDI VDRHREKTLR LLWKIAFAFQ VDISLNLDQL KEEIAFLKHT KSIKKTISLL
SCHSDDLINK KKGKRDSGSF EQYSENIKLL MDWVNAVCAF YNKKVENFTV SFSDGRVLCY
LIHHYHPCYV PFDAICQRTT QTVECTQTGS VVLNSSSESD DSSLDMSLKA FDHENTSELY
KELLENEKKN FHLVRSAVRD LGGIPAMINH SDMSNTIPDE KVVITYLSFL CARLLDLRKE
IRAARLIQTT WRKYKLKTDL KRHQEREKAA RIIQSAVINF LAKQRLRKRV NAALVVQKYW
RRVLAQRKLL MLKKEKLEKV QNKAASLIQG YWRRYSTRRR FLKLKYYSII LQSRIRMIIA
VTSYKRYLWA TVTIQRHWRA YLRRKQDQQR YEMLKSSTLI IQSMFRKWKR RKMQSQVKAT
VILQRAFREW HLRKQAKEEN SAIVIQSWYR MHKELRKYIY IRSCVVIIQK RFRCFQAQKL
YKRKKESILT IQKYYKAYLK GKIERTNYLQ KRAAAIQLQA AFRRLKAHNL CRQIRAAGVI
QSYWRMRQDR VRFLNLKKTI IKLQAHVRKH QQLQKYKKMK KAAVIIQTHF RAYIFARKVL
ASYQKTRSAV IVLQSAYRGM QARKMYIHIL TSVIKIQSYY RAYVSKKEFL SLKNATIKLQ
SIVKVKQTRK QYLHLRAAAL FIQQCYRSKK IAAQKREEYM QMRESCIKLQ AFVRGYRVRK
QMRLQRKAVI SLQSYFRMRK ARQYYLKMYK AIIVIQNYYH AYKAQVNQRK NFLQVKKAAT
CLQAAYRGYK VRQLIKQQSI AALKIQSAFR GYNKRIKYQS VLQSIIKIQR WYRAYKTLHD
TRTHFLKTKA AVISLQSTYR GWKVRKQIRR EHQAALKIQS AFRMAKARKQ FRLFKTAALV
IQQNFRAWTA GRKQRMEYIE LRHAVLMLQS MWKGKTLRRQ LQRQHKCAII IQSYYRMHVQ
QKKWKIMKKA ALLIQKYYRA YSIGREQNHL YLKTKAAVVT LQSAYRGMKV RKRIKDCNKA
AVTIQSKYRA YKTKKKYATY RASAIIIQRW YRGIKITNHQ HKEYLNLKKT AIKIQSVYRG
IRVRRHIQHM HRAATFIKAM FKMHQSRISY HTMRKAAIVI QVRFRAYYQG KMQHEKYLTI
LKAVKILQAS FRGVRVRRTL RKMQIAATLI QSNYRRYRQQ TYFNKLKKIT KTVQQRYRAM
KERNIQFQRY NKLRHSVIYI QAIFRGKKAR RHLKMMHIAA TLIQRRFRTL MMRRRFLSLK
KTAIWIQRKY RAHLYTKHHL QFLRVQNAVI KIQSSYRRWM IRKRMREMHR AATFIQAIFR
MRRLHMRYQA LKQASVVIQQ QYQANRAAKL QRQHYLRQRH SAVILQAAFR GMKTRRHLKS
MHSSATLIQS RFRSLLVRRR FISLKKATIF VQRKYRATIC AKHKLHQFLH LRKSAITIQS
SYRRLMVKKK LQEMQRAAVL IQATFRMHRT YITFQTWKHA SILIQQHYRT YRAAKLQREN
YIRQWHSAVV IQAAYKGMKA RQLLREKHKA AIIIQSTYRM YRQYCFYQKL QWATKIIQEK
YRANKKKQKA FQHNELKKET CVQAGFQDMN IKKQIQDQHQ AAIIIQKNCK AFKIRKHYLH
LRATVVSIQR RYRKLTAVRT QAVICIQSYY RGFKVRKDIQ NMHRAATLIQ SFYRMHRAKV
DYQTKKTAIV VIQNYYRLYV RVKTERKSFL AVQKSVRTIQ PAFRGMKVRQ KLKNLSEEKM
AAIVNQSALC CYRSKTQYEA VQSEGVMIQE WYKASGLACS QEAEYHSQSR AAVTIQKAFC
RMATRKLETQ KCAALRIQFF LQMAVYRRRF VQQKRAAITL QHYFRTWQTR KQFLLYRKAA
VVLQNHYRAF LSAKHQRQVY LQIRSSVIII QARSKGFIQK RKFQEIKNST IKIQAIWRRY
RAKKYLCKVK AACKIQAWYR CWRAHKEYLA ILKAVKIIQG CFYTKLERTR FLNVRASAII
IQRKWRAILS AKIAHEHFLM IKRHRATCLI QAHYRGYKGR QVFLRQKSAA LVIQKYIRAR
EAGKRERIKY IEFKKSTVIL QALVRGWLVR KRILEQRAKI RLLHFTAAAY YHLNALRIQR
AYKLYLAVKN ANKQVNSVIC IQRWFRARLQ RKRFIQKYHS IKKIEHEGQE CLSQQNRAAS
VIQKAVRHFL LRKKQEKFTS GIIKIQALWR GYSWRKKNDC TKIKAIRLSL QVVNREIREE
NKLYKRTALA LHYLLTYKHL SAILEALKHL EVVTRLSPLC CENMAQSGAI SKIFVLIRSC
NRSVPCMEVI RYAVQVLLNV SKYEKTTSAV YDVENCIDIL LELLQIYREK PGNKVADKGG
SIFTKTCCLL AILLKTTNRA SDVRSRSKVV DRIYSLYKLT AHKHKMNTER ILYKQKKNSS
ISIPFIPETP VRTRIVSRLK PNWVLRRDNM EEITNPLQAI QMVMDTLGIP Y