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ASPM_PONPY
ID   ASPM_PONPY              Reviewed;        3471 AA.
AC   P62294;
DT   05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   23-FEB-2022, entry version 84.
DE   RecName: Full=Abnormal spindle-like microcephaly-associated protein homolog;
GN   Name=ASPM;
OS   Pongo pygmaeus (Bornean orangutan).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9600;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=14704186; DOI=10.1093/genetics/165.4.2063;
RA   Zhang J.;
RT   "Evolution of the human ASPM gene, a major determinant of brain size.";
RL   Genetics 165:2063-2070(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=14722158; DOI=10.1093/hmg/ddh055;
RA   Evans P.D., Anderson J.R., Vallender E.J., Gilbert S.L., Malcom C.M.,
RA   Dorus S., Lahn B.T.;
RT   "Adaptive evolution of ASPM, a major determinant of cerebral cortical size
RT   in humans.";
RL   Hum. Mol. Genet. 13:489-494(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=15045028; DOI=10.1371/journal.pbio.0020126;
RA   Kouprina N., Pavlicek A., Mochida G.H., Solomon G., Gersch W., Yoon Y.-H.,
RA   Collura R., Ruvolo M., Barrett J.C., Woods C.G., Walsh C.A., Jurka J.,
RA   Larionov V.;
RT   "Accelerated evolution of the ASPM gene controlling brain size begins prior
RT   to human brain expansion.";
RL   PLoS Biol. 2:653-663(2004).
CC   -!- FUNCTION: Probable role in mitotic spindle regulation and coordination
CC       of mitotic processes. May have a preferential role in regulating
CC       neurogenesis (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton,
CC       spindle {ECO:0000250}. Nucleus {ECO:0000250}. Note=The nuclear-
CC       cytoplasmic distribution could be regulated by the availability of
CC       calmodulin. Localizes to spindle poles during mitosis (By similarity).
CC       {ECO:0000250}.
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DR   EMBL; AY367067; AAR12643.1; -; mRNA.
DR   EMBL; AY488966; AAR84353.1; -; Genomic_DNA.
DR   EMBL; AY488939; AAR84353.1; JOINED; Genomic_DNA.
DR   EMBL; AY488940; AAR84353.1; JOINED; Genomic_DNA.
DR   EMBL; AY488941; AAR84353.1; JOINED; Genomic_DNA.
DR   EMBL; AY488942; AAR84353.1; JOINED; Genomic_DNA.
DR   EMBL; AY488943; AAR84353.1; JOINED; Genomic_DNA.
DR   EMBL; AY488944; AAR84353.1; JOINED; Genomic_DNA.
DR   EMBL; AY488945; AAR84353.1; JOINED; Genomic_DNA.
DR   EMBL; AY488946; AAR84353.1; JOINED; Genomic_DNA.
DR   EMBL; AY488947; AAR84353.1; JOINED; Genomic_DNA.
DR   EMBL; AY488948; AAR84353.1; JOINED; Genomic_DNA.
DR   EMBL; AY488949; AAR84353.1; JOINED; Genomic_DNA.
DR   EMBL; AY488950; AAR84353.1; JOINED; Genomic_DNA.
DR   EMBL; AY488951; AAR84353.1; JOINED; Genomic_DNA.
DR   EMBL; AY488952; AAR84353.1; JOINED; Genomic_DNA.
DR   EMBL; AY488953; AAR84353.1; JOINED; Genomic_DNA.
DR   EMBL; AY488954; AAR84353.1; JOINED; Genomic_DNA.
DR   EMBL; AY488955; AAR84353.1; JOINED; Genomic_DNA.
DR   EMBL; AY488956; AAR84353.1; JOINED; Genomic_DNA.
DR   EMBL; AY488957; AAR84353.1; JOINED; Genomic_DNA.
DR   EMBL; AY488958; AAR84353.1; JOINED; Genomic_DNA.
DR   EMBL; AY488959; AAR84353.1; JOINED; Genomic_DNA.
DR   EMBL; AY488960; AAR84353.1; JOINED; Genomic_DNA.
DR   EMBL; AY488961; AAR84353.1; JOINED; Genomic_DNA.
DR   EMBL; AY488962; AAR84353.1; JOINED; Genomic_DNA.
DR   EMBL; AY488963; AAR84353.1; JOINED; Genomic_DNA.
DR   EMBL; AY488964; AAR84353.1; JOINED; Genomic_DNA.
DR   EMBL; AY488965; AAR84353.1; JOINED; Genomic_DNA.
DR   EMBL; AY497017; AAS48532.1; -; Genomic_DNA.
DR   SMR; P62294; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR   GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007051; P:spindle organization; IEA:InterPro.
DR   Gene3D; 1.10.418.10; -; 2.
DR   Gene3D; 1.25.10.10; -; 1.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR031549; ASH.
DR   InterPro; IPR029955; ASPM.
DR   InterPro; IPR001715; CH-domain.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR22590:SF4; PTHR22590:SF4; 6.
DR   Pfam; PF15780; ASH; 1.
DR   Pfam; PF00307; CH; 1.
DR   Pfam; PF00612; IQ; 36.
DR   SMART; SM00033; CH; 2.
DR   SMART; SM00015; IQ; 65.
DR   SUPFAM; SSF47576; SSF47576; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF52540; SSF52540; 16.
DR   PROSITE; PS50021; CH; 2.
DR   PROSITE; PS50096; IQ; 39.
PE   2: Evidence at transcript level;
KW   Calmodulin-binding; Cell cycle; Cell division; Coiled coil; Cytoplasm;
KW   Cytoskeleton; Mitosis; Nucleus; Phosphoprotein; Repeat.
FT   CHAIN           1..3471
FT                   /note="Abnormal spindle-like microcephaly-associated
FT                   protein homolog"
FT                   /id="PRO_0000191338"
FT   DOMAIN          914..1050
FT                   /note="Calponin-homology (CH) 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT   DOMAIN          1104..1255
FT                   /note="Calponin-homology (CH) 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT   DOMAIN          1341..1372
FT                   /note="IQ 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          1387..1416
FT                   /note="IQ 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          1576..1607
FT                   /note="IQ 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          1599..1628
FT                   /note="IQ 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          1626..1655
FT                   /note="IQ 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          1649..1678
FT                   /note="IQ 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          1722..1751
FT                   /note="IQ 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          1745..1776
FT                   /note="IQ 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          1795..1824
FT                   /note="IQ 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          1818..1847
FT                   /note="IQ 10"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          1868..1897
FT                   /note="IQ 11"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          1891..1922
FT                   /note="IQ 12"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          1941..1972
FT                   /note="IQ 13"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          1964..1995
FT                   /note="IQ 14"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          2014..2043
FT                   /note="IQ 15"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          2037..2068
FT                   /note="IQ 16"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          2087..2118
FT                   /note="IQ 17"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          2110..2141
FT                   /note="IQ 18"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          2160..2191
FT                   /note="IQ 19"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          2183..2212
FT                   /note="IQ 20"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          2233..2264
FT                   /note="IQ 21"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          2256..2287
FT                   /note="IQ 22"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          2305..2336
FT                   /note="IQ 23"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          2378..2409
FT                   /note="IQ 24"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          2401..2432
FT                   /note="IQ 25"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          2451..2482
FT                   /note="IQ 26"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          2524..2555
FT                   /note="IQ 27"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          2659..2690
FT                   /note="IQ 28"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          2682..2713
FT                   /note="IQ 29"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          2732..2761
FT                   /note="IQ 30"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          2853..2884
FT                   /note="IQ 31"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          2903..2932
FT                   /note="IQ 32"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          2926..2957
FT                   /note="IQ 33"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          2948..2979
FT                   /note="IQ 34"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          3023..3054
FT                   /note="IQ 35"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          3073..3104
FT                   /note="IQ 36"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          3134..3163
FT                   /note="IQ 37"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          3175..3204
FT                   /note="IQ 38"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          3198..3229
FT                   /note="IQ 39"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          555..576
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1051..1072
FT                   /evidence="ECO:0000255"
FT   MOD_RES         274
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT   MOD_RES         277
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT   MOD_RES         361
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT   MOD_RES         386
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT   MOD_RES         419
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT   MOD_RES         599
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT   MOD_RES         1097
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT   CONFLICT        150
FT                   /note="K -> R (in Ref. 1; AAR12643)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        303
FT                   /note="T -> S (in Ref. 3; AAS48532)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        350
FT                   /note="Missing (in Ref. 3; AAS48532)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        710
FT                   /note="F -> L (in Ref. 1; AAR12643)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        772
FT                   /note="M -> I (in Ref. 3; AAS48532)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1607
FT                   /note="Q -> R (in Ref. 1; AAR12643)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        2398
FT                   /note="L -> S (in Ref. 1; AAR12643)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        2454
FT                   /note="S -> A (in Ref. 2; AAR84353)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        2471
FT                   /note="L -> S (in Ref. 1; AAR12643)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        2490
FT                   /note="T -> A (in Ref. 1; AAR12643)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        2936
FT                   /note="I -> M (in Ref. 1; AAR12643)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        3000
FT                   /note="I -> T (in Ref. 3; AAS48532)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        3045
FT                   /note="R -> Q (in Ref. 3; AAS48532)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        3196
FT                   /note="E -> G (in Ref. 1; AAR12643)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        3268
FT                   /note="K -> R (in Ref. 1; AAR12643)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   3471 AA;  409369 MW;  0FB9E2902D8E8B4A CRC64;
     MANRRVGRGC WEVSPTERRP PAAEEEASSP PVLSLSHFCR SPFLCFGDVL LGASRTLSLA
     LDNPNEEVAE VKISHFPAAD LGFSVSQRCF VLQPKEKIVI SVNWTPFKEG RVREIMTFLV
     NDVLKHQAIL LGNAEEQKKK KRSLWDTIKK KKISASTSHN RRVSNIQNVN KTFSVSQKVD
     RVRSPLQACE NLAMNEGGPP TENNSLTLEG NKIPISPISP AFNECHGETC LPLSVRRSTT
     YSSLHASENR ELLNVDSASV SKVSFNEKAV TETSFNSINV NGQSGENSKL SLTPNYSSTL
     NITQSQIHFL SPDSFVNNSH GANNELELVT CLSSDMFMKD NSKPVHLEST IAHEIYQKIL
     SPDSFIKDNY GLNQDVESES VNPILSPNQF LKDNMAYMCT SQQTCKVPLS NENSQVPQSP
     QDWRKSEVLP RIPECQGSKS PKAIFEELVE MKSNYYSFIK QNNPKFSVVQ DISSHSHNKQ
     PKRRPILSAT VTKRKATCTR ENQTEINKPK AKRCLNSAVG EHEKVINNQK EKEDFHSYLP
     IIDPILSKSK SYKNEVTPSS TTASVARKRK SDGSMEDADV RVAVTEHTEV REIKRIHFSP
     SEPKTSAVKK TKNVITPISK RISNREKLNL KKKTDLSIFK TPISKTNKRT KPIIAVAQSN
     LTFIKPLKTD IPRHPMPFAA KNMFYDERWK EKQEQGFTWW LNFILTPDDF TVKTNISEVN
     AATLLLGIEN QHKISVPRAP TKEEMSLRAY TARCRLNRLR RAACRLFTSE KMIKAIKKLE
     IEIEARRLIV RKDRHLWKDV GERQKVLNWL LSYNPLWLRI GLETTYGELI SLEDNSDVTG
     LAMFILNRLL WNPDIAAEYR HPTVPHLYRD GHEEALSKFT LKKLLLLVCF LDYAKISRLI
     DHDPCLFCKD AEFKASKEIL LAFSRDFLSG EGDLSRHLGL LGLPVNHVQT PFDEFDFAVT
     NLAVDLQCGV RLVRTMELLT QNWDLSKKLR IPAISRLQKM HNVDIVLQVL KSRGIELSDE
     HGNTILSKDI VDRHREKTLR LLWKIAFAFQ VDISLNLDQL KEEIAFLKHT KSIKKTISLL
     SCHSDDLINK KKGKRDSGSF EQYSENIKLL MDWVNAVCAF YNKKVENFTV SFSDGRVLCY
     LIHHYHPCYV PFDAICQRTT QTVECTQTGS VVLNSSSESD DSSLDMSLKA FDHENTSELY
     KELLENEKKN FHLVRSAVRD LGGIPAMINH SDMSNTIPDE KVVITYLSFL CARLLDLRKE
     IRAARLIQTT WRKYKLKTDL KRHQEREKAA RIIQSAVINF LAKQRLRKRV NAALVVQKYW
     RRVLAQRKLL MLKKEKLEKV QNKAASLIQG YWRRYSTRRR FLKLKYYSII LQSRIRMIIA
     VTSYKRYLWA TVTIQRHWRA YLRRKQDQQR YEMLKSSTLI IQSMFRKWKR RKMQSQVKAT
     VILQRAFREW HLRKQAKEEN SAIVIQSWYR MHKELRKYIY IRSCVVIIQK RFRCFQAQKL
     YKRKKESILT IQKYYKAYLK GKIERTNYLQ KRAAAIQLQA AFRRLKAHNL CRQIRAAGVI
     QSYWRMRQDR VRFLNLKKTI IKLQAHVRKH QQLQKYKKMK KAAVIIQTHF RAYIFARKVL
     ASYQKTRSAV IVLQSAYRGM QARKMYIHIL TSVIKIQSYY RAYVSKKEFL SLKNATIKLQ
     SIVKVKQTRK QYLHLRAAAL FIQQCYRSKK IAAQKREEYM QMRESCIKLQ AFVRGYRVRK
     QMRLQRKAVI SLQSYFRMRK ARQYYLKMYK AIIVIQNYYH AYKAQVNQRK NFLQVKKAAT
     CLQAAYRGYK VRQLIKQQSI AALKIQSAFR GYNKRIKYQS VLQSIIKIQR WYRAYKTLHD
     TRTHFLKTKA AVISLQSTYR GWKVRKQIRR EHQAALKIQS AFRMAKARKQ FRLFKTAALV
     IQQNFRAWTA GRKQRMEYIE LRHAVLMLQS MWKGKTLRRQ LQRQHKCAII IQSYYRMHVQ
     QKKWKIMKKA ALLIQKYYRA YSIGREQNHL YLKTKAAVVT LQSAYRGMKV RKRIKDCNKA
     AVTIQSKYRA YKTKKKYATY RASAIIIQRW YRGIKITNHQ HKEYLNLKKT AIKIQSVYRG
     IRVRRHIQHM HRAATFIKAM FKMHQSRISY HTMRKAAIVI QVRFRAYYQG KMQHEKYLTI
     LKAVKILQAS FRGVRVRRTL RKMQIAATLI QSNYRRYRQQ TYFNKLKKIT KTVQQRYRAM
     KERNIQFQRY NKLRHSVIYI QAIFRGKKAR RHLKMMHIAA TLIQRRFRTL MMRRRFLSLK
     KTAIWIQRKY RAHLYTKHHL QFLRVQNAVI KIQSSYRRWM IRKRMREMHR AATFIQAIFR
     MRRLHMRYQA LKQASVVIQQ QYQANRAAKL QRQHYLRQRH SAVILQAAFR GMKTRRHLKS
     MHSSATLIQS RFRSLLVRRR FISLKKATIF VQRKYRATIC AKHKLHQFLH LRKSAITIQS
     SYRRLMVKKK LQEMQRAAVL IQATFRMHRT YITFQTWKHA SILIQQHYRT YRAAKLQREN
     YIRQWHSAVV IQAAYKGMKA RQLLREKHKA AIIIQSTYRM YRQYCFYQKL QWATKIIQEK
     YRANKKKQKA FQHNELKKET CVQAGFQDMN IKKQIQDQHQ AAIIIQKNCK AFKIRKHYLH
     LRATVVSIQR RYRKLTAVRT QAVICIQSYY RGFKVRKDIQ NMHRAATLIQ SFYRMHRAKV
     DYQTKKTAIV VIQNYYRLYV RVKTERKSFL AVQKSVRTIQ PAFRGMKVRQ KLKNLSEEKM
     AAIVNQSALC CYRSKTQYEA VQSEGVMIQE WYKASGLACS QEAEYHSQSR AAVTIQKAFC
     RMATRKLETQ KCAALRIQFF LQMAVYRRRF VQQKRAAITL QHYFRTWQTR KQFLLYRKAA
     VVLQNHYRAF LSAKHQRQVY LQIRSSVIII QARSKGFIQK RKFQEIKNST IKIQAIWRRY
     RAKKYLCKVK AACKIQAWYR CWRAHKEYLA ILKAVKIIQG CFYTKLERTR FLNVRASAII
     IQRKWRAILS AKIAHEHFLM IKRHRATCLI QAHYRGYKGR QVFLRQKSAA LVIQKYIRAR
     EAGKRERIKY IEFKKSTVIL QALVRGWLVR KRILEQRAKI RLLHFTAAAY YHLNALRIQR
     AYKLYLAVKN ANKQVNSVIC IQRWFRARLQ RKRFIQKYHS IKKIEHEGQE CLSQQNRAAS
     VIQKAVRHFL LRKKQEKFTS GIIKIQALWR GYSWRKKNDC TKIKAIRLSL QVVNREIREE
     NKLYKRTALA LHYLLTYKHL SAILEALKHL EVVTRLSPLC CENMAQSGAI SKIFVLIRSC
     NRSVPCMEVI RYAVQVLLNV SKYEKTTSAV YDVENCIDIL LELLQIYREK PGNKVADKGG
     SIFTKTCCLL AILLKTTNRA SDVRSRSKVV DRIYSLYKLT AHKHKMNTER ILYKQKKNSS
     ISIPFIPETP VRTRIVSRLK PNWVLRRDNM EEITNPLQAI QMVMDTLGIP Y
 
 
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